RSRC1 and SRPK1

Number of citations of the paper that reports this interaction (PubMedID 23602568)
55

Data Source:
BioGRID (enzymatic study)

		RSRC1	SRPK1
Description		arginine and serine rich coiled-coil 1	SRSF protein kinase 1
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Nuclear Speck	Nucleus Nucleoplasm Cytoplasm Endoplasmic Reticulum Cytosol Plasma Membrane Nuclear Matrix
	Molecular Function	Protein Binding	Magnesium Ion Binding RNA Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding
	Biological Process	Alternative MRNA Splicing, Via Spliceosome MRNA Splicing, Via Spliceosome Protein Phosphorylation Nucleocytoplasmic Transport RNA Splicing Response To Antibiotic	Spliceosomal Complex Assembly Protein Phosphorylation Chromosome Segregation RNA Splicing Regulation Of Gene Expression Viral Process Sperm Chromatin Condensation Intracellular Signal Transduction Positive Regulation Of Viral Genome Replication Negative Regulation Of Viral Genome Replication Innate Immune Response Regulation Of MRNA Splicing, Via Spliceosome Regulation Of MRNA Processing
Pathways
Drugs
Diseases
GWAS		anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Body mass index ( 26426971) Chin dimples ( 27182965) Chronic obstructive pulmonary disease or high blood pressure (pleiotropy) ( 30940143) Depression ( 29700475) Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Diastolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) FEV1 ( 30804560) Height ( 23563607) Lung function (FVC) ( 30804560) Lung function in heavy smokers (high FEV1 vs average FEV1) ( 26423011) Major depressive disorder ( 27479909) Neuroticism ( 29255261) Sporadic neuroblastoma ( 28545128) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Systolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858)	Antidepressant treatment resistance (> 2 drugs prescribed) ( 30700811)
Interacting Genes		7 interacting genes: ACTR3B EEF1A1 GDF9 LSM2 SRPK1 SRPK2 UTP14A	171 interacting genes: ADPRH AHCYL1 ALKBH3 AMMECR1L APEX1 APP ARGLU1 ARHGAP12 ARHGAP26 ASAH1 ASXL1 AURKA AURKC C11orf52 C11orf87 C16orf78 C18orf25 C9orf72 CACNB1 CAMK2D CBX5 CDC42EP3 CDK7 CDKL3 CHEK2 CHERP CHUK CIAO1 CLIC5 CLK1 CLK4 CRHR1 CSAG1 DAW1 DDX47 DHX8 DHX9 DNAJC8 DUSP6 ECM1 EIF3M EPB41L4A EPHA3 ERBB2 ESRRG FAM124A FAM76B FERMT1 FGF12 FHL1 FKBP3 FLOT1 FLT1 GABARAP GABARAPL1 HBS1L HIRIP3 HMGN3 HNRNPA1 IFIT5 IKBKG JHY KCNAB1 KCNN2 KIAA1841 KPNA2 KPTN KRR1 LAMC1 LARP1 LBR LCE3D LIMK1 LINC00312 LUC7L3 MACROH2A1 MAGEB1 MAOB MAP1LC3A MAPK12 MAPK14 MAPKAPK5 MAPT MBNL3 MBP MRPL43 MRPS11 NCK2 NELFE NKAP NOL4L NOP16 NOVA1 NSMCE4A NSRP1 NUDT21 NXT2 OCEL1 ODF3L2 OR6B3 PAK4 PDGFRA PDPK1 PELI1 PELI2 PEX19 PFN1 PHF7 POLR2E PPIA PPIL1 PPIL3 PRM1 PRPF38A PTK2 RBM23 RBM39 RBM8A RBMS2 RIMS4 RNPS1 RPS6KB2 RSRC1 RSRC2 RSRP1 SAFB SCAF11 SEC23B SERPINB10 SETD3 SFMBT1 SLAIN2 SLC4A1AP SNRNP70 SPANXN4 SPATS2 SREK1 SRPK3 SRRM1 SRSF1 SRSF12 SRSF3 SRSF4 SRSF5 SRSF6 SRSF7 SRSF8 STAU1 STK26 SUDS3 TAF1B TFEB TNFRSF10C TOP2A TRA2B TRIM65 U2AF1 U2AF2 UBD UBE2E2 USP39 VANGL1 VDR WDR55 YPEL2 YTHDC1 YWHAG ZMYND11 ZNF444 ZNF514 ZRANB2
Entrez ID		51319	6732
HPRD ID		18006	15992
Ensembl ID		ENSG00000174891	ENSG00000096063
Uniprot IDs		Q96IZ7	Q96SB4
PDB IDs			1WAK 1WBP 3BEG 4WUA 5MXX 5MY8 5NNG 5XV7 6FAD
Enriched GO Terms of Interacting Partners?
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