ZDHHC3 and GABRG2

Number of citations of the paper that reports this interaction (PubMedID 15229235)
92

Data Source:
HPRD (two hybrid, in vivo, in vitro)

		ZDHHC3	GABRG2
Description		zinc finger DHHC-type palmitoyltransferase 3	gamma-aminobutyric acid type A receptor subunit gamma2
Image		No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Endoplasmic Reticulum Golgi Apparatus Membrane Integral Component Of Membrane	Plasma Membrane Integral Component Of Plasma Membrane Cell Junction Axon Cytoplasmic Vesicle Membrane Dendrite Membrane Chloride Channel Complex Neuron Projection Synapse Postsynaptic Membrane Postsynapse GABA-ergic Synapse GABA-A Receptor Complex
	Molecular Function	Palmitoyltransferase Activity Protein-cysteine S-palmitoyltransferase Activity	GABA-A Receptor Activity Inhibitory Extracellular Ligand-gated Ion Channel Activity Chloride Channel Activity Protein Binding Benzodiazepine Receptor Activity GABA-gated Chloride Ion Channel Activity Transmitter-gated Ion Channel Activity Involved In Regulation Of Postsynaptic Membrane Potential
	Biological Process	Protein Targeting To Membrane Peptidyl-L-cysteine S-palmitoylation Protein Palmitoylation Protein Localization To Photoreceptor Outer Segment	Signal Transduction Gamma-aminobutyric Acid Signaling Pathway Chemical Synaptic Transmission Post-embryonic Development Adult Behavior Ion Transmembrane Transport Regulation Of Membrane Potential Nervous System Process Synaptic Transmission, GABAergic Regulation Of Postsynaptic Membrane Potential Cellular Response To Histamine Chloride Transmembrane Transport Inhibitory Synapse Assembly
Pathways			Signaling by ERBB4 GABA receptor activation GABA receptor activation
Drugs			Lorazepam Ethchlorvynol Enflurane Temazepam Temazepam Butabarbital Butalbital Topiramate Etomidate Talbutal Pentobarbital Olanzapine Clobazam Meprobamate Carisoprodol Eszopiclone Alprazolam Zolpidem Metharbital Chlordiazepoxide Amoxapine Adinazolam Clorazepate Acamprosate Midazolam Flurazepam Isoflurane Primidone Halazepam Halazepam Propofol Diazepam Diazepam Oxazepam Oxazepam Triazolam Triazolam Methoxyflurane Ergoloid mesylate Clonazepam Methyprylon Halothane Desflurane Flumazenil Flumazenil Estazolam Estazolam Sevoflurane Ginkgo biloba Glutethimide Flunitrazepam Bromazepam Clotiazepam Fludiazepam Prazepam Prazepam Quazepam Quazepam Cinolazepam Nitrazepam Prasterone Taurine Adipiplon Stiripentol Etizolam Thiocolchicoside Muscimol Lormetazepam
Diseases			Febrile seizures, including: Febrile convulsions; Generalized epilepsy with febrile seizure plus (GEFS+); Dravet syndrome/ Severe myoclonic epilepsy in infancy (SMEI) Idiopathic generalied epilepsies (IGEs), including: Childhood absence epilepsy (CAE); Juvenile absence epilepsy (JAE); Juvenile myoclonic epilepsy (JME); Epilepsy with generalized tonic-clonic seizures alone
GWAS		Acne (severe) ( 24927181) Bipolar disorder ( 31043756) Cerebrospinal fluid t-tau:AB1-42 ratio ( 30153862) Depressive symptom improvement ( 30468137)	Angiotensin-converting enzyme inhibitor intolerance ( 28030426) Cognitive decline rate in late mild cognitive impairment ( 26252872) Post bronchodilator FEV1/FVC ratio in COPD ( 26634245) Severe influenza A (H1N1) infection ( 26379185)
Interacting Genes		5 interacting genes: EWSR1 GABRG2 NEDD4L SMAD1 UBQLN4	8 interacting genes: DRD5 GABARAP GABRA2 LARP7 PPP3CA PRKCA PRKCB ZDHHC3
Entrez ID		51304	2566
HPRD ID		15718	00663
Ensembl ID		ENSG00000163812	ENSG00000113327
Uniprot IDs		F8W6M3 Q9NYG2	P18507
PDB IDs			6D6T 6D6U 6HUG 6HUJ 6HUK 6HUO 6HUP 6I53
Enriched GO Terms of Interacting Partners?
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