PLCE1 and KIT

Number of citations of the paper that reports this interaction (PubMedID 12878163)
12

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vitro)

		PLCE1	KIT
Description		phospholipase C epsilon 1	KIT proto-oncogene, receptor tyrosine kinase
Image
GO Annotations	Cellular Component	Golgi Membrane Cell Cytosol Plasma Membrane	Fibrillar Center Acrosomal Vesicle Extracellular Space Plasma Membrane Integral Component Of Plasma Membrane Cell-cell Junction External Side Of Plasma Membrane Cytoplasmic Side Of Plasma Membrane Mast Cell Granule Receptor Complex
	Molecular Function	Phosphatidylinositol Phospholipase C Activity Phospholipase C Activity Guanyl-nucleotide Exchange Factor Activity Protein Binding Ras GTPase Binding Enzyme Binding Metal Ion Binding	Protease Binding Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Stem Cell Factor Receptor Activity Protein Binding ATP Binding Growth Factor Binding Cytokine Binding SH2 Domain Binding Protein Homodimerization Activity Metal Ion Binding
	Biological Process	Activation Of MAPK Activity Regulation Of Cell Growth Diacylglycerol Biosynthetic Process Regulation Of Smooth Muscle Contraction Cytoskeleton Organization Epidermal Growth Factor Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Ras Protein Signal Transduction Heart Development Regulation Of G Protein-coupled Receptor Signaling Pathway Lipid Catabolic Process Calcium-mediated Signaling Glomerulus Development Inositol Trisphosphate Biosynthetic Process Inositol Phosphate Metabolic Process Regulation Of Protein Kinase Activity Regulation Of Ras Protein Signal Transduction Phosphatidylinositol-mediated Signaling Inositol Phosphate-mediated Signaling Release Of Sequestered Calcium Ion Into Cytosol	MAPK Cascade Activation Of MAPK Activity Ovarian Follicle Development Hematopoietic Progenitor Cell Differentiation Myeloid Progenitor Cell Differentiation Lymphoid Progenitor Cell Differentiation Immature B Cell Differentiation Dendritic Cell Cytokine Production Mast Cell Chemotaxis Regulation Of Transcription By RNA Polymerase II Glycosphingolipid Metabolic Process Inflammatory Response Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Multicellular Organism Development Spermatogenesis Spermatid Development Positive Regulation Of Cell Proliferation Germ Cell Migration Regulation Of Cell Shape Visual Learning Male Gonad Development Positive Regulation Of Gene Expression Positive Regulation Of Phospholipase C Activity Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Peptidyl-tyrosine Phosphorylation Cytokine-mediated Signaling Pathway Stem Cell Population Maintenance Lamellipodium Assembly Hemopoiesis B Cell Differentiation T Cell Differentiation Erythrocyte Differentiation Melanocyte Differentiation Positive Regulation Of Cell Migration Positive Regulation Of Pseudopodium Assembly Actin Cytoskeleton Reorganization Mast Cell Cytokine Production Positive Regulation Of Kinase Activity Somatic Stem Cell Population Maintenance Embryonic Hemopoiesis Ectopic Germ Cell Programmed Cell Death Hematopoietic Stem Cell Migration Megakaryocyte Development Fc Receptor Signaling Pathway Kit Signaling Pathway Erythropoietin-mediated Signaling Pathway Regulation Of Cell Proliferation Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Negative Regulation Of Programmed Cell Death Mast Cell Degranulation Positive Regulation Of MAP Kinase Activity Positive Regulation Of MAPK Cascade Pigmentation Positive Regulation Of Phosphatidylinositol 3-kinase Activity Tongue Development Positive Regulation Of Notch Signaling Pathway Positive Regulation Of JAK-STAT Cascade Response To Cadmium Ion Protein Autophosphorylation Somatic Stem Cell Division Positive Regulation Of Long-term Neuronal Synaptic Plasticity Digestive Tract Development Stem Cell Differentiation Epithelial Cell Proliferation Detection Of Mechanical Stimulus Involved In Sensory Perception Of Sound Positive Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of Protein Kinase B Signaling Cell Chemotaxis Mast Cell Differentiation Mast Cell Proliferation Cellular Response To Thyroid Hormone Stimulus Melanocyte Migration Melanocyte Adhesion Positive Regulation Of Pyloric Antrum Smooth Muscle Contraction Regulation Of Bile Acid Metabolic Process Positive Regulation Of Colon Smooth Muscle Contraction Positive Regulation Of Small Intestine Smooth Muscle Contraction Positive Regulation Of Vascular Smooth Muscle Cell Differentiation
Pathways		Synthesis of IP3 and IP4 in the cytosol	PIP3 activates AKT signaling Signaling by SCF-KIT Signaling by SCF-KIT Regulation of KIT signaling Regulation of KIT signaling Constitutive Signaling by Aberrant PI3K in Cancer RAF/MAP kinase cascade PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling TFAP2 (AP-2) family regulates transcription of growth factors and their receptors
Drugs			Sorafenib Imatinib Dasatinib Sunitinib Phosphonotyrosine Nilotinib XL820 OSI-930 ABT-869 Pazopanib Midostaurin Regorafenib Ponatinib Lenvatinib Amuvatinib
Diseases		Nephrotic syndrome and focal segmental glomerulosclerosis	Piebaldism Acute myeloid leukemia (AML)
GWAS		Birth weight ( 31043758) Body fat distribution (arm fat ratio) ( 30664634) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Coronary artery disease ( 29212778) Dengue shock syndrome ( 22001756) Diastolic blood pressure ( 27841878 21909115 27618452) Esophageal cancer ( 21642993) Esophageal cancer and gastric cancer ( 20729852) Esophageal squamous cell carcinoma ( 25129146) Glaucoma ( 31959993) Glaucoma (primary open-angle) ( 29891935) Glucose homeostasis traits ( 25524916) Hypertension ( 31879980 21909115) Lifetime average cigarettes per day in chronic obstructive pulmonary disease ( 21685187) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Medication use (calcium channel blockers) ( 31015401) Migraine ( 27182965 27322543) Offspring birth weight ( 31043758) Optic cup area ( 31798171) Personality traits in bipolar disorder ( 21368711) Plasma clozapine-norclozapine ratio in treatment-resistant schizophrenia ( 30922102) Plateletcrit ( 27863252) Pulse pressure ( 27841878 28739976 30578418) Response to (pegylated) interferon in chronic hepatitis B ( 30715261) Sudden cardiac arrest ( 21658281) Systolic blood pressure ( 27841878 21909115 28739976 27618452 30578418) Vertical cup-disc ratio ( 31798171 25241763) Waist-to-hip ratio adjusted for BMI (additive genetic model) ( 30778226) Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction) ( 28448500) Waist-to-hip ratio adjusted for body mass index ( 28448500)	Anorexia nervosa or obsessive-compulsive disorder ( 30087453) Bipolar disorder ( 19416921) Breastfeeding duration ( 25475840) Cadmium levels ( 26025379) Hematocrit ( 29403010 28017375) Hemoglobin ( 29403010) Hemoglobin levels ( 28017375) Mean corpuscular hemoglobin ( 29403010 28453575 28017375) Mean corpuscular volume ( 29403010 28453575 20139978 28017375 19862010) Platelet count ( 29403010) Red blood cell count ( 29403010 28453575 28017375) Red blood cell traits ( 23222517) Schizophrenia ( 26198764) Serum VEGFR2 concentration ( 25411163) Systemic lupus erythematosus ( 29494758)
Interacting Genes		4 interacting genes: GHITM HRAS KIT NRAS	60 interacting genes: ABL1 BTK CBL CBLB CD81 CD9 CISH CLTC CRK CRKL CSF1R CSF2RA CSF2RB DOK1 EPOR FYN GRAP GRAP2 GRB10 GRB2 GRB7 HCK IL7R ILKAP INPP5D JAK2 JAK3 KITLG LCK LYN MATK MPDZ PIK3CG PIK3R1 PIK3R2 PLCE1 PLCG1 PRKCA PRKCB PTPN11 PTPN20 PTPN6 PTPRO PTPRU RASA1 SH2B2 SH2B3 SOCS1 SOCS5 SOCS6 SPRED1 SPRED2 SRC STAP1 STAT1 STAT5A STAT5B STYX TEC YES1
Entrez ID		51196	3815
HPRD ID		07087	01287
Ensembl ID		ENSG00000138193	ENSG00000157404
Uniprot IDs		B7ZM61 Q9P212	A0A0U2N547 P10721
PDB IDs		2BYE 2BYF 2C5L	1PKG 1QZJ 1QZK 1R01 1T45 1T46 2E9W 2EC8 2IUH 2VIF 3G0E 3G0F 4HVS 4K94 4K9E 4PGZ 4U0I 6GQJ 6GQK 6GQL 6GQM 6HH1 6ITT 6ITV 6KLA 6MOB
Enriched GO Terms of Interacting Partners?
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