ABHD5 and PNPLA2

Number of citations of the paper that reports this interaction (PubMedID 17189257)
109

Data Source:
BioGRID (fluorescent resonance energy transfer, protein complementation assay)

		ABHD5	PNPLA2
Description		abhydrolase domain containing 5, lysophosphatidic acid acyltransferase	patatin like phospholipase domain containing 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Lipid Droplet Cytosol	Nucleoplasm Cytoplasm Endoplasmic Reticulum Lumen Endoplasmic Reticulum Membrane Lipid Droplet Cytosol Plasma Membrane Membrane Integral Component Of Membrane
	Molecular Function	1-acylglycerol-3-phosphate O-acyltransferase Activity Triglyceride Lipase Activity Lysophosphatidic Acid Acyltransferase Activity Carboxylic Ester Hydrolase Activity	Triglyceride Lipase Activity
	Biological Process	Fatty Acid Metabolic Process Phosphatidic Acid Biosynthetic Process Negative Regulation Of Sequestering Of Triglyceride Positive Regulation Of Triglyceride Catabolic Process Cell Differentiation Positive Regulation Of Lipoprotein Lipase Activity Lipid Homeostasis	Negative Regulation Of Sequestering Of Triglyceride Positive Regulation Of Triglyceride Catabolic Process Triglyceride Catabolic Process Lipid Storage Lipid Droplet Organization Acylglycerol Acyl-chain Remodeling Post-translational Protein Modification Cellular Protein Metabolic Process Lipid Homeostasis
Pathways		Triglyceride catabolism	Acyl chain remodeling of DAG and TAG Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein phosphorylation
Drugs
Diseases		Dorfman-Chanarin syndrome; Chanarin-Dorfman syndrome
GWAS		General risk tolerance (MTAG) ( 30643258) Inflammatory skin disease ( 25574825)	Body fat distribution (arm fat ratio) ( 30664634) Keratoconus ( 31855235)
Interacting Genes		3 interacting genes: PLIN1 PLIN2 PNPLA2	10 interacting genes: ABHD5 ARFGEF2 CYTH2 FAF2 GBF1 MARK3 PHYHIP SERPINF1 SMAD9 UBE2R2
Entrez ID		51099	57104
HPRD ID		11986	11443
Ensembl ID		ENSG00000011198	ENSG00000177666
Uniprot IDs		A0A0S2Z5D6 Q8WTS1	Q96AD5
PDB IDs
Enriched GO Terms of Interacting Partners?
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