MRPL4 and EIF2B1

Number of citations of the paper that reports this interaction (PubMedID 16169070)
820

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		MRPL4	EIF2B1
Description		mitochondrial ribosomal protein L4	eukaryotic translation initiation factor 2B subunit alpha
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GO Annotations	Cellular Component	Mitochondrion Mitochondrial Inner Membrane Mitochondrial Large Ribosomal Subunit	Cytoplasm Cytosol Eukaryotic Translation Initiation Factor 2B Complex Plasma Membrane Membrane
	Molecular Function	RNA Binding Structural Constituent Of Ribosome Protein Binding	Translation Initiation Factor Activity Guanyl-nucleotide Exchange Factor Activity Protein Binding Identical Protein Binding
	Biological Process	Mitochondrial Translational Elongation Mitochondrial Translational Termination	Translational Initiation Regulation Of Translational Initiation Response To Heat Response To Glucose Oligodendrocyte Development Response To Peptide Hormone T Cell Receptor Signaling Pathway
Pathways		Mitochondrial translation initiation Mitochondrial translation elongation Mitochondrial translation elongation Mitochondrial translation termination	Recycling of eIF2:GDP
Drugs
Diseases			Leukoencephalopathy with vanishing white matter; Vanishing white matter disease; Childhood ataxia with diffuse central nervous system hypomyelination (CACH); Cree leukoencephalopathy (CLE)
GWAS		Alanine transaminase levels ( 29403010) Pulse pressure ( 27841878) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age <50) ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)	Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		9 interacting genes: CLK2 CSNK2A1 DDX24 ECSIT EIF2B1 EXOSC6 KRTAP4-12 TRIM23 XRN2	15 interacting genes: ADRA2A ADRA2B ADRA2C ADRB2 ARL4D BZW2 CREBBP EIF2B2 EIF2S1 EIF2S2 EPM2A GORASP2 MRPL4 NTAQ1 RD3
Entrez ID		51073	1967
HPRD ID		14759	09458
Ensembl ID		ENSG00000105364	ENSG00000111361
Uniprot IDs		A0A024R7C5 Q9BYD3 X6RAY8	Q14232
PDB IDs		3J7Y 3J9M 5OOL 5OOM 6NU2 6NU3	3ECS 6CAJ 6EZO 6K71 6K72 6O81 6O85 6O9Z
Enriched GO Terms of Interacting Partners?
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