PBX1 and HOXB8

Number of citations of the paper that reports this interaction (PubMedID 11571641)
13

Data Source:
HPRD (in vivo)

		PBX1	HOXB8
Description		PBX homeobox 1	homeobox B8
Image			No pdb structure
GO Annotations	Cellular Component	Nuclear Chromatin Nucleus Nucleoplasm Cytoplasm RNA Polymerase II Transcription Factor Complex	Nuclear Chromatin Nucleoplasm
	Molecular Function	RNA Polymerase II Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding	DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific Sequence-specific DNA Binding
	Biological Process	Branching Involved In Ureteric Bud Morphogenesis Steroid Biosynthetic Process Positive Regulation Of Transcription Of Notch Receptor Target Sex Differentiation Positive Regulation Of Cell Proliferation Anterior/posterior Pattern Specification Proximal/distal Pattern Formation Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Regulation Of Ossification Adrenal Gland Development Embryonic Limb Morphogenesis Somatic Stem Cell Population Maintenance Embryonic Hemopoiesis Negative Regulation Of Neuron Differentiation Spleen Development Thymus Development Embryonic Skeletal System Development	Negative Regulation Of Transcription By RNA Polymerase II Grooming Behavior Adult Locomotory Behavior Anterior/posterior Pattern Specification Sensory Perception Of Pain Dorsal Spinal Cord Development Negative Regulation Of Myeloid Cell Differentiation Embryonic Skeletal System Morphogenesis
Pathways		Transcriptional regulation of pluripotent stem cells Activation of anterior HOX genes in hindbrain development during early embryogenesis NOTCH3 Intracellular Domain Regulates Transcription
Drugs
Diseases		Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia)
GWAS		Asthma ( 29273806) Breast cancer (prognosis) ( 23319801) Cough in response to angiotensin-converting enzyme inhibitor drugs ( 28084903) Early-onset Parkinson's disease ( 28256260) Height ( 20966902) Myopia ( 27182965) Night sleep phenotypes ( 27126917) Pre-treatment viral load in HIV-1 infection ( 31219150) Response to methotrexate in juvenile idiopathic arthritis ( 24709693) Spherical equivalent or myopia (age of diagnosis) ( 29808027)
Interacting Genes		23 interacting genes: CREBBP HOXA10 HOXA5 HOXA9 HOXB1 HOXB7 HOXB8 HOXD10 HOXD4 HOXD9 KAT2A MDM2 MEIS1 MEIS2 MYH10 NEDD4L NR3C1 PAX6 PBX2 PDX1 PKNOX1 POU2F1 SMARCD3	4 interacting genes: MEIS1 PBX1 PBX2 PBX3
Entrez ID		5087	3218
HPRD ID		08889	00851
Ensembl ID		ENSG00000185630	ENSG00000120068
Uniprot IDs		A1MJ41 A8K5V0 P40424 Q53YC7	I3L3R1 P17481 Q8N8T3
PDB IDs		1B72 1PUF
Enriched GO Terms of Interacting Partners?
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