FURIN and SORCS1

Number of citations of the paper that reports this interaction (PubMedID 12482870)
12

Data Source:
HPRD (in vivo, in vitro)

		FURIN	SORCS1
Description		furin, paired basic amino acid cleaving enzyme	sortilin related VPS10 domain containing receptor 1
Image			No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Extracellular Region Extracellular Space Endoplasmic Reticulum Golgi Lumen Trans-Golgi Network Plasma Membrane Cell Surface Endosome Membrane Membrane Trans-Golgi Network Transport Vesicle Integral Component Of Golgi Membrane Membrane Raft Extracellular Exosome	Golgi Apparatus Membrane Integral Component Of Membrane
	Molecular Function	Protease Binding Endopeptidase Activity Serine-type Endopeptidase Activity Serine-type Endopeptidase Inhibitor Activity Protein Binding Peptidase Activity Peptide Binding Metal Ion Binding Nerve Growth Factor Binding	Protein Binding Neuropeptide Receptor Activity
	Biological Process	Blastocyst Formation Signal Peptide Processing Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Signal Transduction Negative Regulation Of Endopeptidase Activity Protein Processing Peptide Hormone Processing Viral Life Cycle Viral Protein Processing Extracellular Matrix Disassembly Extracellular Matrix Organization Collagen Catabolic Process Zymogen Activation Nerve Growth Factor Processing Negative Regulation Of Low-density Lipoprotein Particle Receptor Catabolic Process Nerve Growth Factor Production Negative Regulation Of Nerve Growth Factor Production Negative Regulation Of Transforming Growth Factor Beta1 Production Secretion By Cell Regulation Of Protein Catabolic Process Peptide Biosynthetic Process Cellular Protein Metabolic Process Regulation Of Low-density Lipoprotein Particle Receptor Biosynthetic Process Regulation Of Lipoprotein Lipase Activity Positive Regulation Of Membrane Protein Ectodomain Proteolysis Regulation Of Endopeptidase Activity Cornification Dibasic Protein Processing Positive Regulation Of Transforming Growth Factor Beta1 Activation	Post-Golgi Vesicle-mediated Transport Neuropeptide Signaling Pathway
Pathways		Signaling by NODAL Collagen degradation Collagen degradation Elastic fibre formation Activation of Matrix Metalloproteinases Removal of aminoterminal propeptides from gamma-carboxylated proteins NGF processing Synthesis and processing of ENV and VPU Signaling by PDGF Pre-NOTCH Processing in Golgi TGF-beta receptor signaling activates SMADs Uptake and function of anthrax toxins Formation of the cornified envelope Assembly of active LPL and LIPC lipase complexes CD163 mediating an anti-inflammatory response Amyloid fiber formation
Drugs		Capric acid Pirfenidone
Diseases
GWAS		Age at first sexual intercourse ( 27089180) anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Autism spectrum disorder or schizophrenia ( 28540026) Birth weight ( 31043758) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Coronary artery disease ( 29212778 26343387) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975) Daytime sleep phenotypes ( 27126917) Diastolic blood pressure ( 21909115 28739976 27618452) Diastolic blood pressure (cigarette smoking interaction) ( 29455858) Diastolic blood pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962) Diastolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) General risk tolerance (MTAG) ( 30643258) Hypertension ( 21909115 30487518) Ischemic stroke ( 29531354) Mean arterial pressure ( 27618448 30487518) Mean arterial pressure x alcohol consumption interaction (2df test) ( 29912962) Myocardial infarction ( 26343387) Offspring birth weight ( 31043758) Parental longevity (combined parental age at death) ( 29227965) Parental longevity (combined parental attained age, Martingale residuals) ( 29227965) Parental longevity (father's attained age) ( 29227965) Risk-taking tendency (4-domain principal component model) ( 30643258) Schizophrenia ( 25056061 29483656 30285260) Stroke ( 29531354) Systolic blood pressure ( 26390057 28135244 21909115 29403010 28739976 27618452) Systolic blood pressure (cigarette smoking interaction) ( 29455858) Systolic blood pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962) Systolic blood pressure x alcohol consumption interaction (2df test) ( 29912962)	Abnormal white matter microstructure in first episode schizophrenia (multivariate analysis) ( 28924203) Asparaginase hypersensitivity in acute lymphoblastic leukemia ( 25987655) Benign prostatic hyperplasia ( 30988330) Circulating leptin levels in high cardiovascular risk ( 31766143) Endometriosis ( 23472165) Metabolite levels (Pyroglutamine) ( 23934736) Methadone dose in opioid dependence ( 28115739) Systemic juvenile idiopathic arthritis ( 27927641) White matter microstructure in first episode schizophrenia (left posterior cingulate cortex) ( 28924203)
Interacting Genes		28 interacting genes: ABCC6 ADAM19 ADAMTS1 ADAMTS4 AP2M1 BACE1 CNMD COL23A1 DSG3 EDA FLNA FLNC ITM2C LRP1 MMP14 NAGPA NOTCH1 PACS1 PDGFA PMCH PRB4 SERPINB8 SORCS1 SORL1 TNFSF13 VWF ZP3 ZP4	2 interacting genes: FURIN SORT1
Entrez ID		5045	114815
HPRD ID		00653	12098
Ensembl ID		ENSG00000140564	ENSG00000108018
Uniprot IDs		A0A024RC70 P09958	A8K182 B3KVZ0 B3KWN9 E6Y3F9 E6Y3G0 Q8WY21
PDB IDs		4OMC 4OMD 4RYD 4Z2A 5JMO 5JXG 5JXH 5JXI 5JXJ 5MIM 6A8Y 6EQV 6EQW 6EQX 6HLB 6HLD 6HLE 6HZA 6HZB 6HZC 6HZD
Enriched GO Terms of Interacting Partners?
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