FURIN and SORCS1

  • Number of citations of the paper that reports this interaction (PubMedID 12482870)
  • 12
  • Data Source:
  • HPRD (in vivo, in vitro)

FURIN

SORCS1

Description furin, paired basic amino acid cleaving enzyme sortilin related VPS10 domain containing receptor 1
Image No pdb structure
GO Annotations Cellular Component
Molecular Function
Biological Process
Pathways
Drugs
Diseases
GWAS
  • Age at first sexual intercourse ( 27089180)
  • anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028)
  • Autism spectrum disorder or schizophrenia ( 28540026)
  • Birth weight ( 31043758)
  • Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203)
  • Coronary artery disease ( 29212778 26343387)
  • Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975)
  • Daytime sleep phenotypes ( 27126917)
  • Diastolic blood pressure ( 21909115 28739976 27618452)
  • Diastolic blood pressure (cigarette smoking interaction) ( 29455858)
  • Diastolic blood pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962)
  • Diastolic blood pressure x alcohol consumption interaction (2df test) ( 29912962)
  • General risk tolerance (MTAG) ( 30643258)
  • Hypertension ( 21909115 30487518)
  • Ischemic stroke ( 29531354)
  • Mean arterial pressure ( 27618448 30487518)
  • Mean arterial pressure x alcohol consumption interaction (2df test) ( 29912962)
  • Myocardial infarction ( 26343387)
  • Offspring birth weight ( 31043758)
  • Parental longevity (combined parental age at death) ( 29227965)
  • Parental longevity (combined parental attained age, Martingale residuals) ( 29227965)
  • Parental longevity (father's attained age) ( 29227965)
  • Risk-taking tendency (4-domain principal component model) ( 30643258)
  • Schizophrenia ( 25056061 29483656 30285260)
  • Stroke ( 29531354)
  • Systolic blood pressure ( 26390057 28135244 21909115 29403010 28739976 27618452)
  • Systolic blood pressure (cigarette smoking interaction) ( 29455858)
  • Systolic blood pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962)
  • Systolic blood pressure x alcohol consumption interaction (2df test) ( 29912962)
  • Abnormal white matter microstructure in first episode schizophrenia (multivariate analysis) ( 28924203)
  • Asparaginase hypersensitivity in acute lymphoblastic leukemia ( 25987655)
  • Benign prostatic hyperplasia ( 30988330)
  • Circulating leptin levels in high cardiovascular risk ( 31766143)
  • Endometriosis ( 23472165)
  • Metabolite levels (Pyroglutamine) ( 23934736)
  • Methadone dose in opioid dependence ( 28115739)
  • Systemic juvenile idiopathic arthritis ( 27927641)
  • White matter microstructure in first episode schizophrenia (left posterior cingulate cortex) ( 28924203)
Interacting Genes 28 interacting genes: ABCC6 ADAM19 ADAMTS1 ADAMTS4 AP2M1 BACE1 CNMD COL23A1 DSG3 EDA FLNA FLNC ITM2C LRP1 MMP14 NAGPA NOTCH1 PACS1 PDGFA PMCH PRB4 SERPINB8 SORCS1 SORL1 TNFSF13 VWF ZP3 ZP4 2 interacting genes: FURIN SORT1
Entrez ID 5045 114815
HPRD ID 00653 12098
Ensembl ID ENSG00000140564 ENSG00000108018
Uniprot IDs A0A024RC70 P09958 A8K182 B3KVZ0 B3KWN9 E6Y3F9 E6Y3G0 Q8WY21
PDB IDs 4OMC 4OMD 4RYD 4Z2A 5JMO 5JXG 5JXH 5JXI 5JXJ 5MIM 6A8Y 6EQV 6EQW 6EQX 6HLB 6HLD 6HLE 6HZA 6HZB 6HZC 6HZD
Enriched GO Terms of Interacting Partners?
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