ORC5 and STAB1

Number of citations of the paper that reports this interaction (PubMedID 21988832)
75

Data Source:
BioGRID (two hybrid)

		ORC5	STAB1
Description		origin recognition complex subunit 5	stabilin 1
Image			No pdb structure
GO Annotations	Cellular Component	Nuclear Chromosome, Telomeric Region Chromatin Origin Recognition Complex Nucleus Nucleoplasm Nuclear Origin Of Replication Recognition Complex Cytosol	Plasma Membrane Integral Component Of Plasma Membrane Endocytic Vesicle Membrane
	Molecular Function	Nucleotide Binding Molecular_function DNA Replication Origin Binding Protein Binding ATP Binding	Low-density Lipoprotein Particle Receptor Activity Scavenger Receptor Activity Calcium Ion Binding Protein Binding Hyaluronic Acid Binding Protein Disulfide Oxidoreductase Activity Low-density Lipoprotein Particle Binding
	Biological Process	G1/S Transition Of Mitotic Cell Cycle DNA Replication DNA Replication Initiation Regulation Of DNA Replication	Receptor-mediated Endocytosis Inflammatory Response Cell Adhesion Cell-cell Signaling Negative Regulation Of Angiogenesis Defense Response To Bacterium Oxidation-reduction Process
Pathways		E2F-enabled inhibition of pre-replication complex formation Activation of ATR in response to replication stress Assembly of the ORC complex at the origin of replication CDC6 association with the ORC:origin complex CDT1 association with the CDC6:ORC:origin complex Assembly of the pre-replicative complex Orc1 removal from chromatin Activation of the pre-replicative complex	Scavenging by Class H Receptors
Drugs
Diseases
GWAS		Alcohol consumption (drinks per week) ( 30643258) Night sleep phenotypes ( 27126917) Sucrose liking ( 31005972)	Autism spectrum disorder or schizophrenia ( 28540026) Bipolar disorder ( 21926972 31043756) Cognitive function ( 25644384) Diverticular disease ( 30177863) HDL cholesterol ( 24097068) HDL cholesterol levels ( 28334899) Height ( 31562340) Hematocrit ( 27863252) Intelligence (MTAG) ( 29326435) Parkinson's disease ( 28892059) Schizophrenia ( 25056061 29483656 23974872) Urinary albumin-to-creatinine ratio ( 31511532) Waist-hip ratio ( 20935629) Waist-to-hip ratio adjusted for BMI (additive genetic model) ( 30778226)
Interacting Genes		30 interacting genes: CALCOCO2 CDC45 CDC5L CDC6 CDC7 DBF4 DMRTA1 H3-4 H4-16 KRT18 LAMB2 MCM2 MCM3 MCM4 MCM5 MCM7 NIF3L1 NONO ORC1 ORC2 ORC3 ORC4 ORC6 RPA2 SIPA1L2 STAB1 TAX1BP1 TXNDC11 UBQLN4 USP2	8 interacting genes: CHID1 GGA1 GGA2 GGA3 ORC5 PIK3R2 RRP9 SRP54
Entrez ID		5001	23166
HPRD ID		09086	09778
Ensembl ID		ENSG00000164815	ENSG00000010327
Uniprot IDs		A4D0P7 O43913 Q53FC8	Q9NY15
PDB IDs		5UJ7 5UJM
Enriched GO Terms of Interacting Partners?
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