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OPRM1 and SIAH2
Number of citations of the paper that reports this interaction (PubMedID
23840749
)
10
Data Source:
BioGRID
(two hybrid, affinity chromatography technology)
OPRM1
SIAH2
Description
opioid receptor mu 1
siah E3 ubiquitin protein ligase 2
Image
No pdb structure
GO Annotations
Cellular Component
Endosome
Endoplasmic Reticulum
Golgi Apparatus
Plasma Membrane
Integral Component Of Plasma Membrane
Focal Adhesion
Axon
Dendrite
Dendrite Membrane
Dendrite Cytoplasm
Sarcolemma
Neuron Projection
Perikaryon
Membrane Raft
Spine Apparatus
Integral Component Of Postsynaptic Membrane
Integral Component Of Presynaptic Membrane
Nucleoplasm
Cytoplasm
Early Endosome
Cytosol
Neuron Projection
Neuronal Cell Body
Intracellular Membrane-bounded Organelle
Molecular Function
G-protein Alpha-subunit Binding
G Protein-coupled Receptor Activity
Beta-endorphin Receptor Activity
Voltage-gated Calcium Channel Activity
Protein Binding
Protein C-terminus Binding
Protein Domain Specific Binding
Filamin Binding
G-protein Beta-subunit Binding
Morphine Receptor Activity
Peptide Binding
Neuropeptide Binding
Transcription Corepressor Activity
Ubiquitin-protein Transferase Activity
Protein Binding
Zinc Ion Binding
Ubiquitin Conjugating Enzyme Binding
Ubiquitin Protein Ligase Activity
Biological Process
Acute Inflammatory Response To Antigenic Stimulus
G Protein-coupled Receptor Signaling Pathway
G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger
Adenylate Cyclase-activating Dopamine Receptor Signaling Pathway
Adenylate Cyclase-inhibiting G Protein-coupled Acetylcholine Receptor Signaling Pathway
Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway
Neuropeptide Signaling Pathway
Sensory Perception
Locomotory Behavior
Negative Regulation Of Cell Proliferation
Response To Radiation
Cytokine-mediated Signaling Pathway
Sensory Perception Of Pain
Adenylate Cyclase-inhibiting Opioid Receptor Signaling Pathway
Response To Food
Positive Regulation Of Appetite
Response To Lipopolysaccharide
Opioid Receptor Signaling Pathway
Wound Healing
Response To Cocaine
Eating Behavior
Estrous Cycle
Behavioral Response To Ethanol
Positive Regulation Of Neurogenesis
Regulation Of Sensory Perception Of Pain
Excitatory Postsynaptic Potential
Negative Regulation Of Wnt Protein Secretion
Positive Regulation Of ERK1 And ERK2 Cascade
Calcium Ion Transmembrane Transport
Response To Growth Factor
Cellular Response To Morphine
Regulation Of Cellular Response To Stress
Negative Regulation Of Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway
Regulation Of NMDA Receptor Activity
Protein Polyubiquitination
Ubiquitin-dependent Protein Catabolic Process
Apoptotic Process
Cell Cycle
Small GTPase Mediated Signal Transduction
Multicellular Organism Development
Protein Deubiquitination
Regulation Of Protein Ubiquitination
Regulation Of Circadian Rhythm
Negative Regulation Of Apoptotic Process
Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Cellular Protein Catabolic Process
Cellular Protein Metabolic Process
Rhythmic Process
Negative Regulation Of Canonical Wnt Signaling Pathway
Negative Regulation Of Netrin-activated Signaling Pathway
Negative Regulation Of Nucleic Acid-templated Transcription
Negative Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways
Opioid Signalling
G-protein activation
Peptide ligand-binding receptors
G alpha (i) signalling events
Interleukin-4 and Interleukin-13 signaling
MECP2 regulates neuronal receptors and channels
Netrin-1 signaling
Ub-specific processing proteases
Amyloid fiber formation
Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Tramadol
Morphine
Codeine
Amitriptyline
Hydromorphone
Methadone
Pethidine
Oxycodone
Levallorphan
Dextromethorphan
Butorphanol
Dextropropoxyphene
Pentazocine
Naltrexone
Sufentanil
Alfentanil
Fentanyl
Loperamide
Nalbuphine
Levorphanol
Remifentanil
Ondansetron
Anileridine
Buprenorphine
Hydrocodone
Diphenoxylate
Naloxone
Oxymorphone
Dezocine
Ketamine
Levomethadyl Acetate
Methadyl Acetate
3-Methylthiofentanyl
Dimethylthiambutene
Heroin
Ethylmorphine
Etorphine
Carfentanil
Diprenorphine
Dihydromorphine
3-Methylfentanyl
V1003
Epicept NP-1
LI-301
Tapentadol
Nalmefene
Alvimopan
Ketobemidone
Methylnaltrexone
Naloxegol
Trimebutine
Eluxadoline
Propoxyphene napsylate
Naldemedine
Diseases
GWAS
Diastolic blood pressure (
30224653
)
Hypertension (
21347282
)
Lipoprotein (a) levels (
26377243
)
Menstruation quality of life impact (fever) (
29855537
)
Methadone dose in opioid dependence (
28115739
)
Type 2 diabetes (age of onset) (
28060188
)
BRCA1/2-negative high-risk breast cancer (
30323354
)
Breast cancer (
22951594
31757997
)
Interacting Genes
22 interacting genes:
CALM1
COPS5
DNAJB4
DOK4
DOK5
FLNA
GNA15
GNAI1
GNAI2
GNAO1
GPRASP1
GRK3
KCNF1
OPRD1
PLD2
PPL
SIAH1
SIAH2
UBC
VAPA
WLS
ZYX
43 interacting genes:
AFF1
AKR1C3
ATN1
CACYBP
CCBE1
CHEK2
DCC
DYRK2
EEF1D
EGLN3
HIPK2
HIPK3
MYD88
NRF1
OPRM1
PEG10
PEG3
PIAS2
PIAS3
PML
POU2AF1
PSMD4
RBBP8
SETD2
SNCA
SNCAIP
SPRY2
STAT3
SYP
TINF2
TP53BP2
TPX2
TRAF2
UBE2D1
UBE2D2
UBE2D3
UBE2I
UBE2L6
UBE2N
UBE2V2
USP13
USP19
VAV1
Entrez ID
4988
6478
HPRD ID
02484
03737
Ensembl ID
ENSG00000112038
ENSG00000181788
Uniprot IDs
B8K2Q5
G8XRH4
G8XRH5
L0E130
P35372
O43255
PDB IDs
5H9M
Enriched GO Terms of Interacting Partners
?
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Tagcloud (Difference)
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Tagcloud (Intersection)
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