OAS1 and EXOC5

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid, two hybrid)

		OAS1	EXOC5
Description		2'-5'-oligoadenylate synthetase 1	exocyst complex component 5
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Nucleus Nucleoplasm Cytoplasm Mitochondrion Endoplasmic Reticulum Cytosol Membrane	Exocyst Cytoplasm Cytosol Midbody
	Molecular Function	2'-5'-oligoadenylate Synthetase Activity Double-stranded RNA Binding Protein Binding ATP Binding Metal Ion Binding	Protein Binding Ral GTPase Binding Protein N-terminus Binding
	Biological Process	Glucose Metabolic Process Response To Virus Glucose Homeostasis Negative Regulation Of Viral Genome Replication Defense Response To Virus Interferon-gamma-mediated Signaling Pathway Type I Interferon Signaling Pathway Regulation Of Ribonuclease Activity	Establishment Of Planar Polarity Exocytosis Post-Golgi Vesicle-mediated Transport Golgi To Plasma Membrane Transport Protein Transport Vesicle Docking Protein Localization To Plasma Membrane Epithelial Cell Apoptotic Process Non-motile Cilium Assembly
Pathways		Interferon gamma signaling OAS antiviral response Interferon alpha/beta signaling	Translocation of SLC2A4 (GLUT4) to the plasma membrane Insulin processing VxPx cargo-targeting to cilium
Drugs		Cysteine-S-Acetamide
Diseases
GWAS		Blood protein levels ( 30072576 29875488) Body mass index ( 26426971) Glycemic traits ( 23575436) Low HDL-cholesterol levels ( 31006500) Response to fenofibrate (adiponectin levels) ( 23149075) Right-sided colonic diverticulosis ( 31089239) Urate levels ( 31578528)	Alcohol consumption ( 23743675) Chronotype ( 30696823) Response to ranibizumab in age-related macular degeneration (exudative) ( 30054556)
Interacting Genes		6 interacting genes: ACTN1 BUD23 EXOC5 PRMT6 RPL30 TRIM27	34 interacting genes: ACTR3B ADCK1 ARF6 BARD1 BRMS1L CCDC102B CDH2 DEUP1 DNAAF4 EDRF1 ENO2 FRMD6 GNB1 HDDC3 HGS ICA1 KXD1 MAGEA6 OAS1 PRKCG PSTPIP1 PTK6 PYCARD RAB14 RAB4A RAB4B RALA SOX10 SPACA9 TBX21 TNPO2 TTC23L TXLNB TXNL4A
Entrez ID		4938	10640
HPRD ID		08879	07258
Ensembl ID		ENSG00000089127	ENSG00000070367
Uniprot IDs		F8VXY3 P00973	O00471
PDB IDs		4IG8
Enriched GO Terms of Interacting Partners?
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