NUCB2 and NDN

Number of citations of the paper that reports this interaction (PubMedID 10915798)
21

Data Source:
HPRD (two hybrid, in vivo, in vitro)

		NUCB2	NDN
Description		nucleobindin 2	necdin, MAGE family member
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Space Nuclear Outer Membrane Endoplasmic Reticulum Endoplasmic Reticulum-Golgi Intermediate Compartment Golgi Apparatus Cytosol Plasma Membrane Extracellular Exosome	Nucleoplasm Centrosome Cytosol Cell Projection Perikaryon
	Molecular Function	G-protein Alpha-subunit Binding DNA Binding Guanyl-nucleotide Exchange Factor Activity Calcium Ion Binding Protein Binding	RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Protein Binding Gamma-tubulin Binding
	Biological Process	Small GTPase Mediated Signal Transduction Negative Regulation Of Appetite	Neuron Migration Respiratory System Process Nervous System Development Axonal Fasciculation Central Nervous System Development Negative Regulation Of Cell Proliferation Glial Cell Migration Post-embryonic Development Cytokine-mediated Signaling Pathway Sensory Perception Of Pain Regulation Of Growth Positive Regulation Of Transcription By RNA Polymerase II Neurotrophin TRK Receptor Signaling Pathway Axon Extension Multicellular Organismal Homeostasis Genetic Imprinting
Pathways			Interleukin-4 and Interleukin-13 signaling
Drugs		Calcium Citrate Calcium Phosphate
Diseases			Prader-Willi and Angelman syndromes, including: Angelman syndrome (AS); Prader-Willi syndrome (PWS)
GWAS		Blood protein levels ( 29875488) Body mass index ( 26426971) Height ( 20881960) Pulse pressure ( 27841878) Systolic blood pressure ( 27841878 28739976) Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500) Waist circumference adjusted for BMI in active individuals ( 28448500) Waist circumference adjusted for body mass index ( 28448500)	Depressive symptoms (SSRI exposure interaction) ( 25649181) Plasma anti-thyroid peroxidase levels ( 29678681) Serum metabolite concentrations in chronic kidney disease ( 29545352)
Interacting Genes		8 interacting genes: GADD45A GNAI3 GNAS NDN NR1I2 SMARCD1 STAR XPO1	47 interacting genes: APBB1IP ARSL BLOC1S6 CALCOCO2 CCDC136 CDR2 DTNBP1 E2F1 E2F4 EEF1AKMT1 EGFR EID1 EPAS1 FAM131C FSD2 FXR2 GKAP1 GOLGA2 HIF1A HNRNPU IFFO1 IL1A IL32 IRS4 LAX1 LPXN MIER2 MKRN2 MPP6 MYG1 NEFL NGFR NUBP1 NUCB1 NUCB2 P4HA3 PJA1 PPARGC1A PPFIA1 SERTAD3 SIRT1 SSX2IP TFIP11 TP53 U2AF1 ZBTB1 ZBTB7B
Entrez ID		4925	4692
HPRD ID		09726	03667
Ensembl ID		ENSG00000070081	ENSG00000182636
Uniprot IDs		P80303 Q2L696	Q99608 X5D982
PDB IDs
Enriched GO Terms of Interacting Partners?
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