ROR1 and DUSP18

Number of citations of the paper that reports this interaction (PubMedID 28065597)
26

Data Source:
BioGRID (two hybrid)

		ROR1	DUSP18
Description		receptor tyrosine kinase like orphan receptor 1	dual specificity phosphatase 18
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GO Annotations	Cellular Component	Stress Fiber Cytoplasm Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Axon Receptor Complex Axon Terminus	Nucleus Nucleoplasm Cytoplasm Mitochondrial Inner Membrane
	Molecular Function	Transmembrane Receptor Protein Tyrosine Kinase Activity Protein Binding ATP Binding Wnt-protein Binding Wnt-activated Receptor Activity Coreceptor Activity Involved In Wnt Signaling Pathway, Planar Cell Polarity Pathway	Protein Tyrosine Phosphatase Activity Protein Binding Protein Tyrosine/serine/threonine Phosphatase Activity Phosphatase Activity MAP Kinase Tyrosine/serine/threonine Phosphatase Activity
	Biological Process	Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Multicellular Organism Development Nervous System Development Sensory Perception Of Sound Positive Regulation Of Neuron Projection Development Astrocyte Development Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Peptidyl-tyrosine Phosphorylation Positive Regulation Of Kinase Activity Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Regulation Of MAPK Cascade Positive Regulation Of MAPK Cascade Inner Ear Development Anatomical Structure Development Positive Regulation Of NF-kappaB Transcription Factor Activity Wnt Signaling Pathway, Planar Cell Polarity Pathway Positive Regulation Of ERK1 And ERK2 Cascade	Inactivation Of MAPK Activity Dephosphorylation Peptidyl-tyrosine Dephosphorylation Peptidyl-threonine Dephosphorylation
Pathways		WNT5A-dependent internalization of FZD2, FZD5 and ROR2
Drugs
Diseases
GWAS		Blood protein levels ( 30072576 29875488) Normal facial asymmetry (angle of surface orientation score) ( 30631343) Pancreatic cancer ( 26098869) Severe bacterial meningitis ( 31092817)
Interacting Genes		13 interacting genes: APP DUPD1 DUSP14 DUSP18 DUSP19 DUSP21 ILKAP MFHAS1 PPM1B PPM1F PTPN6 PTPRR STYX	14 interacting genes: EPHA2 EPHA3 EPHA7 EPHB6 ERBB2 ERBB3 ERBB4 IGF1R INSR MAPK8IP2 PTK7 ROR1 ROR2 TEK
Entrez ID		4919	150290
HPRD ID		03821	13253
Ensembl ID		ENSG00000185483	ENSG00000167065
Uniprot IDs		Q01973	A0A024R1L2 F2Z2P2 Q8NEJ0
PDB IDs		5Z55 6BA5 6BAN	2ESB
Enriched GO Terms of Interacting Partners?
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