NID1 and LAMC2

Number of citations of the paper that reports this interaction (PubMedID 11733994)
31

Data Source:
HPRD (in vitro)

		NID1	LAMC2
Description		nidogen 1	laminin subunit gamma 2
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Basement Membrane Plasma Membrane Receptor Complex Collagen-containing Extracellular Matrix Extracellular Exosome	Extracellular Region Basement Membrane Laminin-2 Complex Extracellular Space Cell Cortex Membrane Perinuclear Region Of Cytoplasm Collagen-containing Extracellular Matrix
	Molecular Function	Extracellular Matrix Structural Constituent Calcium Ion Binding Collagen Binding Wnt-protein Binding Wnt-activated Receptor Activity Laminin Binding Laminin-1 Binding Proteoglycan Binding	Extracellular Matrix Structural Constituent Heparin Binding
	Biological Process	Cell-matrix Adhesion Positive Regulation Of Cell-substrate Adhesion Extracellular Matrix Organization Glomerular Basement Membrane Development Canonical Wnt Signaling Pathway Basement Membrane Organization	Cell Adhesion Motor Neuron Axon Guidance Positive Regulation Of Cell Proliferation Epidermis Development Animal Organ Morphogenesis Tissue Development Dendrite Development Extracellular Matrix Organization Positive Regulation Of Cell Migration Hemidesmosome Assembly
Pathways		Degradation of the extracellular matrix Degradation of the extracellular matrix Laminin interactions Laminin interactions	Degradation of the extracellular matrix Degradation of the extracellular matrix Assembly of collagen fibrils and other multimeric structures Anchoring fibril formation Laminin interactions Laminin interactions Non-integrin membrane-ECM interactions Type I hemidesmosome assembly MET activates PTK2 signaling
Drugs		Urokinase
Diseases			Epidermolysis bullosa, junctional, including: Epidermolysis bullosa, junctional, Herlitz type (JEB-H); Epidermolysis bullosa, junctional, non-Herlitz type (JEB-nH); Epidermolysis bullosa, junctional, with pyloric atresia (JEB-PA)
GWAS		Blood protein levels ( 30072576) Cutaneous nevi ( 21478494) Diverticulitis ( 28585551) Urate levels in overweight individuals ( 25811787)	Acne (severe) ( 30542056) Blood protein levels ( 30072576 29875488) Clozapine-induced agranulocytosis ( 25187353) HDL cholesterol ( 21347282) Morning person ( 30696823) Systemic lupus erythematosus ( 21408207)
Interacting Genes		21 interacting genes: APP COL13A1 COL1A1 COL4A1 FBLN1 FBLN2 FGA FGB HSPG2 ITGAV ITGB3 LACRT LAMA1 LAMC1 LAMC2 LGALS3BP PLAU PLXDC1 PRELP PTPRF SKIL	8 interacting genes: BMP1 COL7A1 CSF1R FBLN2 LAMB3 NID1 SCAP SLA2
Entrez ID		4811	3918
HPRD ID		00574	01031
Ensembl ID		ENSG00000116962	ENSG00000058085
Uniprot IDs		P14543	Q13753
PDB IDs		1NDX
Enriched GO Terms of Interacting Partners?
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