NFE2L2 and JUND

Number of citations of the paper that reports this interaction (PubMedID 9872330)
124

Data Source:
HPRD (in vivo)

		NFE2L2	JUND
Description		nuclear factor, erythroid 2 like 2	JunD proto-oncogene, AP-1 transcription factor subunit
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GO Annotations	Cellular Component	Nuclear Chromatin Cell Nucleus Nucleoplasm Cytoplasm Golgi Apparatus Centrosome Cytosol Plasma Membrane Protein-DNA Complex	Chromatin Nuclear Chromatin Nucleoplasm Transcription Factor Complex Protein-DNA Complex Transcription Factor AP-1 Complex
	Molecular Function	Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific RNA Polymerase II Activating Transcription Factor Binding Transcription Cofactor Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Protein Domain Specific Binding Sequence-specific DNA Binding Transcription Regulatory Region DNA Binding	RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Transcription Coactivator Activity Protein Binding Transcription Factor Binding Nuclear Receptor Binding Enzyme Binding Transcription Regulatory Region DNA Binding
	Biological Process	Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Inflammatory Response Aging Proteasomal Ubiquitin-independent Protein Catabolic Process Positive Regulation Of Gene Expression Negative Regulation Of Cardiac Muscle Cell Apoptotic Process Positive Regulation Of Neuron Projection Development Viral Process Protein Ubiquitination Positive Regulation Of Blood Coagulation Endoplasmic Reticulum Unfolded Protein Response Cellular Response To Oxidative Stress Positive Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Positive Regulation Of Transcription From RNA Polymerase II Promoter In Response To Oxidative Stress PERK-mediated Unfolded Protein Response Cellular Response To Glucose Starvation Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Blood Vessel Endothelial Cell Migration Cell Redox Homeostasis Positive Regulation Of Angiogenesis Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Embryonic Development Aflatoxin Catabolic Process Positive Regulation Of Glucose Import Positive Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Cellular Response To Hydrogen Peroxide Cellular Response To Copper Ion Cellular Response To Tumor Necrosis Factor Cellular Response To Fluid Shear Stress Cellular Response To Laminar Fluid Shear Stress Negative Regulation Of Hematopoietic Stem Cell Differentiation Negative Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Positive Regulation Of ER-associated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Hydrogen Peroxide-induced Cell Death Positive Regulation Of Glutathione Biosynthetic Process Cellular Response To Angiotensin Negative Regulation Of Vascular Associated Smooth Muscle Cell Migration Regulation Of Removal Of Superoxide Radicals Negative Regulation Of Endothelial Cell Apoptotic Process Positive Regulation Of Reactive Oxygen Species Metabolic Process	Negative Regulation Of Transcription By RNA Polymerase II Osteoblast Development Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Aging Circadian Rhythm Response To Radiation Response To Light Stimulus Response To Mechanical Stimulus Response To Organic Substance Response To Lipopolysaccharide Cellular Response To Hormone Stimulus Cellular Response To Stress Response To Cytokine Regulation Of Cell Proliferation Response To Drug Response To Peptide Hormone Positive Regulation Of Cell Differentiation Positive Regulation Of Osteoblast Differentiation Positive Regulation Of Transcription By RNA Polymerase II Response To CAMP Regulation Of Cell Cycle Cellular Response To Calcium Ion
Pathways			Estrogen-dependent gene expression NGF-stimulated transcription
Drugs
Diseases
GWAS		Estimated glomerular filtration rate ( 31152163 31451708 30604766) Estimated glomerular filtration rate in non-diabetics ( 31451708)	Bronchodilator response in asthma ( 25562107) Estimated glomerular filtration rate ( 31015462 30604766) Hand grip strength ( 29691431) Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist circumference adjusted for BMI in non-smokers ( 28443625) Waist circumference adjusted for body mass index ( 25673412) Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist-to-hip ratio adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist-to-hip ratio adjusted for BMI in non-smokers ( 28443625) Waist-to-hip ratio adjusted for body mass index ( 25673412) White blood cell count (monocyte) ( 28158719)
Interacting Genes		34 interacting genes: ATF4 BPTF CASP1 CASP3 CDH1 CHD6 COPS7A CREB3 CREBBP DCAF11 EIF2AK3 GSK3B JUN JUND KEAP1 KPNA3 MAFF MAFG MAFK MAPK7 NCOR2 NFE2 NFE2L3 PMF1 PPARG PRKCA PRKCD RBMX SUMO1 SUMO2 TNNT1 TRIM24 UBE2E2 WAC	30 interacting genes: ACTR3 ATF3 BATF BCL6 BRCA1 CCND1 COP1 COPS5 DDIT3 EP300 ESR1 FOS FOSB FOSL2 HINFP JDP2 LINC00461 MAPK1 MAPK3 MAPK8 MAPK9 MDM2 MEN1 NFE2L1 NFE2L2 PPARG SLC25A12 SMAD3 SMAD4 TBP
Entrez ID		4780	3727
HPRD ID		02732	01304
Ensembl ID		ENSG00000116044	ENSG00000130522
Uniprot IDs		Q16236	P17535
PDB IDs		2FLU 2LZ1 3ZGC 4IFL 5WFV	3U86 5VPA 5VPB 5VPC 5VPD 5VPE 5VPF
Enriched GO Terms of Interacting Partners?
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