NFE2 and WWP1

Number of citations of the paper that reports this interaction (PubMedID 9753456)
20

Data Source:
HPRD (in vitro)

		NFE2	WWP1
Description		nuclear factor, erythroid 2	WW domain containing E3 ubiquitin protein ligase 1
Image
GO Annotations	Cellular Component	Nuclear Chromatin Nucleus Nucleoplasm Cytoplasm PML Body Protein-DNA Complex	Ubiquitin Ligase Complex Nucleus Cytoplasm Cytosol Plasma Membrane Extracellular Exosome
	Molecular Function	Transcription Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Proximal Promoter Sequence-specific DNA Binding DNA Binding DNA-binding Transcription Factor Activity Transcription Coactivator Activity Protein Binding Sequence-specific DNA Binding Protein N-terminus Binding WW Domain Binding	Ubiquitin-protein Transferase Activity Protein Binding Ubiquitin Protein Ligase Activity
	Biological Process	Nucleosome Disassembly Regulation Of Transcription By RNA Polymerase II Multicellular Organism Development Blood Coagulation Hemostasis Blood Circulation Regulation Of Megakaryocyte Differentiation Positive Regulation Of Transcription, DNA-templated	Protein Polyubiquitination Ubiquitin-dependent Protein Catabolic Process Signal Transduction Central Nervous System Development Protein Ubiquitination Ion Transmembrane Transport Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Protein Catabolic Process Negative Regulation Of Transcription, DNA-templated Viral Entry Into Host Cell
Pathways		RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function Factors involved in megakaryocyte development and platelet production Factors involved in megakaryocyte development and platelet production	Downregulation of ERBB4 signaling Stimuli-sensing channels Regulation of RUNX2 expression and activity Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Chronotype ( 30696823) Mean platelet volume ( 22139419 24026423) Platelet count ( 29403010 27863252) Plateletcrit ( 27863252) Red cell distribution width ( 28957414) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)	Estimated glomerular filtration rate ( 31152163)
Interacting Genes		22 interacting genes: ATF4 BTRC CREBBP ELF5 HMGN1 ITCH KAT2B MAFF MAFG MAFK MAPK8 NEDD4 NFE2L2 NFE2L3 PEX14 PHYHIP PRIM1 SCAND1 SSX5 TXN WWP1 YAP1	49 interacting genes: ARRDC2 ASH2L ATN1 CLCN5 CPSF6 DAG1 DAZAP2 DIDO1 EWSR1 FAM189A2 FBXL18 HSPB1 IKBKG IL2RG IL6R KLF2 KLF5 LAPTM5 LATS1 LNX1 LZTR1 MACROH2A2 NFE2 NOTCH1 PCBD1 PHF20L1 PRKAA2 RASA1 RNF11 RTN4 RUNX1 SCNN1A SFTPC SMAD3 SMAD5 STAT6 TFAP2A TGIF1 TP53BP2 TRAF4 UBC UBE2D1 UBE2D2 UBE2D3 UBE2L3 WBP1 WBP2 YWHAQ ZNF638
Entrez ID		4778	11059
HPRD ID		09030	03811
Ensembl ID		ENSG00000123405	ENSG00000123124
Uniprot IDs		A8K3E0 Q16621	Q9H0M0
PDB IDs		1LVX 2KZ5	1ND7 2OP7 5HPS 5HPT 6J1X 6J1Y
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?