NF2 and ITGB1

Number of citations of the paper that reports this interaction (PubMedID 12118253)
31

Data Source:
HPRD (in vitro, in vivo)

		NF2	ITGB1
Description		neurofibromin 2	integrin subunit beta 1
Image
GO Annotations	Cellular Component	Nucleus Nucleolus Cytoplasm Early Endosome Cytosol Cytoskeleton Plasma Membrane Adherens Junction Membrane Lamellipodium Cortical Actin Cytoskeleton Filopodium Membrane Cleavage Furrow Ruffle Membrane Neuron Projection Cell Body Apical Part Of Cell Perinuclear Region Of Cytoplasm	Ruffle Cell Cytoplasm Plasma Membrane Focal Adhesion Integrin Complex External Side Of Plasma Membrane Cell Surface Intercalated Disc Membrane Lamellipodium Filopodium Neuromuscular Junction Cleavage Furrow Ruffle Membrane Protein-containing Complex Integrin Alpha1-beta1 Complex Integrin Alpha2-beta1 Complex Integrin Alpha3-beta1 Complex Integrin Alpha5-beta1 Complex Integrin Alpha7-beta1 Complex Integrin Alpha8-beta1 Complex Integrin Alpha10-beta1 Complex Integrin Alpha11-beta1 Complex Myelin Sheath Abaxonal Region Sarcolemma Melanosome Dendritic Spine Receptor Complex Membrane Raft Perinuclear Region Of Cytoplasm Recycling Endosome Extracellular Exosome Invadopodium Membrane Glial Cell Projection Schaffer Collateral - CA1 Synapse Glutamatergic Synapse Integral Component Of Synaptic Membrane
	Molecular Function	Actin Binding Protein Binding	Virus Receptor Activity Fibronectin Binding Protease Binding Actin Binding Integrin Binding Protein Binding Coreceptor Activity C-X3-C Chemokine Binding Laminin Binding Protein-containing Complex Binding Cadherin Binding Metal Ion Binding Protein Heterodimerization Activity Cell Adhesion Molecule Binding Collagen Binding Involved In Cell-matrix Adhesion Protein Tyrosine Kinase Binding
	Biological Process	Mesoderm Formation Negative Regulation Of Cell-matrix Adhesion Negative Regulation Of Protein Kinase Activity Ectoderm Development Negative Regulation Of Cell Proliferation Schwann Cell Proliferation Regulation Of Gliogenesis Hippocampus Development Negative Regulation Of Cell-cell Adhesion Actin Cytoskeleton Organization Negative Regulation Of Cell Migration Regulation Of Protein Stability Regulation Of Hippo Signaling Odontogenesis Of Dentin-containing Tooth Negative Regulation Of Tyrosine Phosphorylation Of STAT Protein Regulation Of Apoptotic Process Negative Regulation Of MAPK Cascade Cell-cell Junction Organization Positive Regulation Of Cell Differentiation Negative Regulation Of JAK-STAT Cascade Positive Regulation Of Stress Fiber Assembly Regulation Of Cell Cycle Lens Fiber Cell Differentiation Regulation Of Stem Cell Proliferation Regulation Of Protein Localization To Nucleus Regulation Of Neural Precursor Cell Proliferation	G1/S Transition Of Mitotic Cell Cycle Establishment Of Mitotic Spindle Orientation In Utero Embryonic Development Cell Fate Specification Cell Migration Involved In Sprouting Angiogenesis Phagocytosis Cellular Defense Response Cell Adhesion Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Leukocyte Cell-cell Adhesion Cell-matrix Adhesion Calcium-independent Cell-matrix Adhesion Transforming Growth Factor Beta Receptor Signaling Pathway Integrin-mediated Signaling Pathway Positive Regulation Of Cell Proliferation Germ Cell Migration Visual Learning Regulation Of Collagen Catabolic Process Positive Regulation Of Fibroblast Migration Cell Migration Cytokine-mediated Signaling Pathway Formation Of Radial Glial Scaffolds CD40 Signaling Pathway Cell Projection Organization Lamellipodium Assembly B Cell Differentiation Extracellular Matrix Organization Positive Regulation Of Cell Migration Cell-substrate Adhesion Receptor Internalization Cell Adhesion Mediated By Integrin Cell-cell Adhesion Mediated By Integrin Heterotypic Cell-cell Adhesion Negative Regulation Of Rho Protein Signal Transduction Positive Regulation Of Apoptotic Process Stress Fiber Assembly Positive Regulation Of GTPase Activity Sarcomere Organization Negative Regulation Of Cell Differentiation Positive Regulation Of Angiogenesis Viral Entry Into Host Cell Mesodermal Cell Differentiation Axon Extension Dendrite Morphogenesis Regulation Of Immune Response Modulation Of Chemical Synaptic Transmission Leukocyte Migration Leukocyte Tethering Or Rolling Regulation Of Cell Cycle Positive Regulation Of Protein Kinase B Signaling Cardiac Muscle Cell Differentiation Cellular Response To Low-density Lipoprotein Particle Stimulus Basement Membrane Organization Positive Regulation Of Wound Healing Positive Regulation Of Protein Localization To Plasma Membrane Positive Regulation Of Signaling Receptor Activity Negative Regulation Of Anoikis
Pathways		Regulation of actin dynamics for phagocytic cup formation RHO GTPases activate PAKs	Elastic fibre formation Fibronectin matrix formation Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Cell surface interactions at the vascular wall Basigin interactions Molecules associated with elastic fibres Integrin cell surface interactions Integrin cell surface interactions Laminin interactions Laminin interactions Syndecan interactions ECM proteoglycans Other semaphorin interactions Signal transduction by L1 Localization of the PINCH-ILK-PARVIN complex to focal adhesions CHL1 interactions RHO GTPases Activate Formins Interleukin-4 and Interleukin-13 signaling Platelet Adhesion to exposed collagen MET activates PTK2 signaling MET interacts with TNS proteins HCMV Early Events
Drugs			Antithymocyte immunoglobulin (rabbit)
Diseases		Malignant pleural mesothelioma Noonan syndrome and related disorders, including: Noonan syndrome (NS); Leopard syndrome (LS); Noonan syndrome-like with loose anagen hair (NS/LAH); CBL-mutation associated syndrome (CBL); Neurofibromatosis type 1 (NF1); Neurofibromatosis type 2 (NF2); Neurofibromatosis-Noonan syndrome (NFNS); Legius syndrome; Cardiofaciocutaneous syndrome (CFCS); Costello syndrome (CS)
GWAS		Carotid atherosclerosis in HIV infection ( 20009918)	Depression (quantitative trait) ( 20800221) Suicide in bipolar disorder ( 25917933)
Interacting Genes		66 interacting genes: AGAP2 AKT1 ARAF ARNT AURKA BECN1 CBLC CCNB1IP1 CCND2 CCNE1 CD44 CDK4 CDK6 CDKN2B CDKN2C CTNNB1 DACH1 DCAF1 EGFR EPHA2 ERBB2 EZR FGFR4 FZR1 GLIS2 GRM1 HGF HGS HIF1A IGF1R ITGB1 KAT2A KDELR2 KDM1A LATS1 LATS2 MAP2K3 MAP2K5 MAP3K5 MAPK14 MDM4 MED28 MET MYC PAK1 PDGFRA PRKCA PXN PYGO2 RAF1 RALGDS RASSF1 SCHIP1 SDCBP SGSM3 SLC9A3R1 SOX3 SOX4 SPTBN1 STK11 TARBP2 TERT TP53 TSC1 TTYH2 XPO1	78 interacting genes: ACAP1 ACTN1 ACTN4 ARHGAP5 CANX CD151 CD36 CD46 CD82 CD9 CRKL DAG1 DOK1 EFNA4 EGFR EPS8 FBLN1 FBXO2 FERMT1 FERMT2 FERMT3 FHL2 FLNA FLNB FLT4 FN1 HSPD1 HSPG2 ICAM4 IGF1R ILK ITGA1 ITGA10 ITGA11 ITGA2 ITGA3 ITGA4 ITGA5 ITGA6 ITGA8 ITGA9 ITGAV ITGB1BP1 ITGB1BP2 LAMA1 LGALS1 LGALS3BP LGALS8 MAP4K4 MET NCKIPSD NF2 NME1 NMRK2 PDHB PIP5K1C PLAUR PRKCA PRKCE PTK2 PXN RAB25 RACK1 SLC3A2 SPP1 TGFBR1 TGM2 TGOLN2 TIMP2 TLN1 TNC TSPAN4 UPF2 VCAM1 VCAN YWHAB ZEB1 ZNF33A
Entrez ID		4771	3688
HPRD ID		06980	00628
Ensembl ID		ENSG00000186575	ENSG00000150093
Uniprot IDs		A0A024R1D9 A0A024R1F6 A0A024R1I0 A0A024R1J8 A0A024R1J9 P35240	P05556
PDB IDs		1H4R 3U8Z 4ZRI 4ZRJ 6CDS	1K11 1LHA 3G9W 3T9K 3VI3 3VI4 4DX9 4WJK 4WK0 4WK2 4WK4
Enriched GO Terms of Interacting Partners?
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