DRG1 and TAL1

Number of citations of the paper that reports this interaction (PubMedID 9824680)
5

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		DRG1	TAL1
Description		developmentally regulated GTP binding protein 1	TAL bHLH transcription factor 1, erythroid differentiation factor
Image
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Polysome Membrane Nuclear Body	Histone Deacetylase Complex Nuclear Chromatin Nucleus Nucleoplasm Transcription Factor Complex Lsd1/2 Complex
	Molecular Function	GTPase Activity Protein Binding GTP Binding Microtubule Binding Transcription Factor Binding Potassium Ion Binding Identical Protein Binding	RNA Polymerase II Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific RNA Polymerase II Transcription Factor Binding Chromatin Binding DNA-binding Transcription Factor Activity Protein Binding Enzyme Binding Histone Deacetylase Binding Transcription Regulatory Region DNA Binding Protein Dimerization Activity E-box Binding
	Biological Process	Cytoplasmic Translation Transcription, DNA-templated Multicellular Organism Development Positive Regulation Of Microtubule Polymerization Regulation Of Mitotic Spindle Assembly	Negative Regulation Of Transcription By RNA Polymerase II Angiogenesis Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Locomotory Behavior Spinal Cord Association Neuron Differentiation Hemopoiesis Erythrocyte Differentiation Megakaryocyte Differentiation Platelet Formation Basophil Differentiation Positive Regulation Of Protein Complex Assembly Embryonic Hemopoiesis Megakaryocyte Development Regulation Of Cell Proliferation Erythrocyte Maturation Cell Fate Commitment Negative Regulation Of Erythrocyte Differentiation Positive Regulation Of Erythrocyte Differentiation Positive Regulation Of Chromatin Assembly Or Disassembly Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Mitotic Cell Cycle Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Cell Division Astrocyte Fate Commitment Definitive Hemopoiesis Hemangioblast Cell Differentiation Hematopoietic Stem Cell Differentiation Regulation Of Mast Cell Differentiation Positive Regulation Of Protein Tyrosine Kinase Activity Regulation Of Hematopoietic Stem Cell Differentiation Regulation Of Stem Cell Population Maintenance Positive Regulation Of Signaling Receptor Activity
Pathways			RUNX1 regulates transcription of genes involved in differentiation of HSCs Transcriptional regulation of granulopoiesis
Drugs
Diseases			Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia)
GWAS		Neutrophil count ( 27863252) Sum basophil neutrophil counts ( 27863252)	Body mass index ( 25673413) Clozapine-induced agranulocytosis ( 25187353) Mean corpuscular volume ( 27863252)
Interacting Genes		13 interacting genes: CAPNS1 CLDN1 COIL LYL1 PHC2 RWDD1 SKIL SRPK2 SSX2IP STK16 TAL1 UBE2I ZC3H15	24 interacting genes: CHD3 DRG1 ELSPBP1 EP300 GATA1 GATA2 GATA3 HDAC1 HOXB9 KAT2B KDM1A LMO1 LMO2 MAPK3 NCAPG2 PRKCQ SIN3A SKP2 SP1 STOML2 STUB1 TCF3 TCF4 ZHX1
Entrez ID		4733	6886
HPRD ID		16034	01753
Ensembl ID		ENSG00000185721	ENSG00000162367
Uniprot IDs		Q9Y295	P17542 Q16509
PDB IDs		2EKI	2YPA 2YPB
Enriched GO Terms of Interacting Partners?
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