PPP1R12B and PRKG1

Number of citations of the paper that reports this interaction (PubMedID 10567269)
139

Data Source:
BioGRID (two hybrid)

		PPP1R12B	PRKG1
Description		protein phosphatase 1 regulatory subunit 12B	protein kinase cGMP-dependent 1
Image		No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Cytosol Cytoskeleton Z Disc A Band	Cytoplasm Golgi Apparatus Cytosol Plasma Membrane
	Molecular Function	Enzyme Inhibitor Activity Protein Binding Enzyme Activator Activity Phosphatase Regulator Activity Protein Kinase Binding	Protein Kinase Activity CGMP-dependent Protein Kinase Activity Calcium Channel Regulator Activity Protein Binding ATP Binding CGMP Binding
	Biological Process	G2/M Transition Of Mitotic Cell Cycle Regulation Of Muscle Contraction Signal Transduction Positive Regulation Of Catalytic Activity Negative Regulation Of Catalytic Activity	Neuron Migration Protein Phosphorylation Signal Transduction Dendrite Development CGMP-mediated Signaling Actin Cytoskeleton Organization Forebrain Development Regulation Of GTPase Activity Relaxation Of Vascular Smooth Muscle Negative Regulation Of Platelet Aggregation Negative Regulation Of Vascular Smooth Muscle Cell Proliferation Negative Regulation Of Vascular Associated Smooth Muscle Cell Migration
Pathways		RHO GTPases activate PKNs RHO GTPases activate PKNs RHO GTPases activate CIT RHO GTPases Activate ROCKs RHO GTPases activate PAKs RHO GTPases activate PAKs	Ca2+ pathway
Drugs
Diseases
GWAS		Celiac disease ( 23936387) Coronary heart disease ( 24778558) Obesity-related traits ( 23251661) Sex ratio ( 26763874)	3-month functional outcome in ischaemic stroke (modified Rankin score) ( 30796134) Alcohol misuse (trauma interaction) ( 28265120) Asthma ( 21907864) Autism spectrum disorder or schizophrenia ( 28540026) Body mass index ( 28552196) Chlamydia trachomatis seropositivity ( 29967566) Colorectal cancer or advanced adenoma ( 30510241) Coronary artery disease ( 29212778) Gait rhythm ( 26219847) Height ( 28552196 31562340) Interferon alpha levels in systemic lupus erythematosus ( 25338677) Logical memory (delayed recall) in normal cognition ( 29274321) Loneliness (multivariate analysis) ( 27629369) Mammographic density (non-dense area) ( 25342443) Mitochondrial DNA copy number ( 30704525) Obesity-related traits ( 23251661) Rosacea symptom severity ( 29771307) Schizophrenia ( 30285260) Triglyceride levels x loop diuretics use interaction ( 31806883)
Interacting Genes		3 interacting genes: IL16 PPP1CB PRKG1	35 interacting genes: ANXA7 AR CFTR CREB1 CRIP2 FAM124A FHOD1 GABRR1 GKAP1 GTF2I HDAC1 IRAG1 ITPR1 LASP1 LMO2 NPR1 PDE5A PLCB3 PPP1R12A PPP1R12B PPP1R17 PRKCA RAF1 RGS2 RYR1 SELL SEPTIN3 SF1 SPP1 TNNT1 TRIM39-RPP21 TRPC3 VASP WDR77 ZNF646
Entrez ID		4660	5592
HPRD ID		04794	08910
Ensembl ID		ENSG00000077157	ENSG00000185532
Uniprot IDs		E1CKY7 O60237	Q13976
PDB IDs			1ZXA 3NMD 3OCP 3OD0 3OGJ 4KU7 4KU8 4QX5 4QXK 4R4L 4R4M 4Z07 5J48 5JAX 5JD7 5L0N 6BDL 6BG2 6C0T
Enriched GO Terms of Interacting Partners?
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