MYOC and CAP1

Number of citations of the paper that reports this interaction (PubMedID 16289162)
27

Data Source:
BioGRID (far western blotting)
HPRD (in vitro)

		MYOC	CAP1
Description		myocilin	cyclase associated actin cytoskeleton regulatory protein 1
Image
GO Annotations	Cellular Component	Extracellular Space Mitochondrial Outer Membrane Mitochondrial Inner Membrane Mitochondrial Intermembrane Space Endoplasmic Reticulum Rough Endoplasmic Reticulum Golgi Apparatus Cilium Cytoplasmic Vesicle Node Of Ranvier Collagen-containing Extracellular Matrix Extracellular Exosome	Extracellular Region Plasma Membrane Focal Adhesion Cortical Actin Cytoskeleton Azurophil Granule Lumen Extracellular Exosome
	Molecular Function	Fibronectin Binding Frizzled Binding Protein Binding Receptor Tyrosine Kinase Binding Myosin Light Chain Binding Metal Ion Binding	Actin Binding Adenylate Cyclase Binding
	Biological Process	Osteoblast Differentiation Negative Regulation Of Cell-matrix Adhesion Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Skeletal Muscle Hypertrophy Myelination In Peripheral Nervous System Positive Regulation Of Cell Migration Neuron Projection Development Negative Regulation Of Rho Protein Signal Transduction Non-canonical Wnt Signaling Pathway Via JNK Cascade ERBB2-ERBB3 Signaling Pathway Regulation Of MAPK Cascade Clustering Of Voltage-gated Sodium Channels Positive Regulation Of Stress Fiber Assembly Negative Regulation Of Stress Fiber Assembly Positive Regulation Of Focal Adhesion Assembly Positive Regulation Of Protein Kinase B Signaling Positive Regulation Of Mitochondrial Depolarization Bone Development Positive Regulation Of Substrate Adhesion-dependent Cell Spreading	Cell Morphogenesis Ameboidal-type Cell Migration Receptor-mediated Endocytosis Establishment Or Maintenance Of Cell Polarity Signal Transduction Activation Of Adenylate Cyclase Activity Actin Polymerization Or Depolymerization Neutrophil Degranulation Regulation Of Adenylate Cyclase Activity
Pathways			Platelet degranulation Role of ABL in ROBO-SLIT signaling Neutrophil degranulation
Drugs
Diseases		Primary open angle glaucoma
GWAS		Cognitive decline rate in late mild cognitive impairment ( 26252872) Glaucoma ( 30104761) Intake of total sugars ( 31005972)
Interacting Genes		40 interacting genes: A2M ACTA2 ACTB ACTG1 ALDOA ANXA2 C1QB CAP1 CD81 CKM CLIC1 COL1A2 COL3A1 ECE1 EEF1A1 ENO1 FBN1 FN1 FTL FUBP1 GAPDH GGTLC1 HAGH IGLL1 ITGA7 LAMA5 LGALS3 MAEA MYL2 NOTCH2 OLFM3 OLFML3 PKLR PKM RFC1 SERPINF1 TGFBR1 TIMP1 TKT TNFRSF1A	9 interacting genes: ACTB ACTG1 BARD1 CAP2 LIG4 MYOC PLA2G4A SERPINB8 UCHL5
Entrez ID		4653	10487
HPRD ID		03387	09869
Ensembl ID		ENSG00000034971	ENSG00000131236
Uniprot IDs		A0A0S2Z421 Q99972	D3DPU2 Q01518
PDB IDs		4WXQ 4WXS 4WXU 6OU0 6OU1 6OU2 6OU3 6PKD 6PKE 6PKF	1K8F
Enriched GO Terms of Interacting Partners?
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