MX2 and ATRIP

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid)

		MX2	ATRIP
Description		MX dynamin like GTPase 2	ATR interacting protein
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GO Annotations	Cellular Component	Nucleus Nuclear Pore Cytoplasm Cytosol Plasma Membrane Postsynaptic Density Microtubule Cytoskeleton Membrane Axon Cytoplasmic Vesicle Mitochondrial Membrane Dendritic Spine Dendritic Spine Head Synapse Postsynaptic Membrane Presynapse Postsynaptic Endocytic Zone Membrane	Nucleoplasm
	Molecular Function	GTPase Activity Protein Binding GTP Binding Microtubule Binding	Protein Binding K63-linked Polyubiquitin Modification-dependent Protein Binding
	Biological Process	Mitochondrial Fission Defense Response Response To Virus Synaptic Vesicle Budding From Presynaptic Endocytic Zone Membrane Receptor Internalization Response To Interferon-alpha Regulation Of Nucleocytoplasmic Transport Organelle Fission Regulation Of Synapse Structure Or Activity MRNA Transport Defense Response To Virus Regulation Of Cell Cycle Type I Interferon Signaling Pathway Membrane Fusion Postsynaptic Neurotransmitter Receptor Internalization	DNA Damage Checkpoint DNA Replication DNA Repair Interstrand Cross-link Repair Regulation Of Signal Transduction By P53 Class Mediator
Pathways		ISG15 antiviral mechanism Interferon alpha/beta signaling	Activation of ATR in response to replication stress HDR through Single Strand Annealing (SSA) Processing of DNA double-strand break ends Presynaptic phase of homologous DNA pairing and strand exchange Fanconi Anemia Pathway Regulation of TP53 Activity through Phosphorylation G2/M DNA damage checkpoint
Drugs
Diseases
GWAS		Melanoma ( 21983787 28212542) Nevus count or cutaneous melanoma ( 30429480) Parkinson disease and lewy body pathology ( 25663231)	Crohn's disease ( 28067908) Inflammatory bowel disease ( 28067908) Ulcerative colitis ( 28067908)
Interacting Genes		3 interacting genes: ATRIP EHMT2 PIAS2	21 interacting genes: BRCA1 C1orf94 CCDC28B CDC23 CDC6 CDK16 CEP164 CINP FAAP100 FAM156A LNX1 METTL21A MID2 MOS MX2 POLR1C PRKDC RPA3 SCG2 SPRY2 TASOR2
Entrez ID		4600	84126
HPRD ID		01001
Ensembl ID		ENSG00000183486	ENSG00000164053
Uniprot IDs		P20592	A0A024R2U4 A0A024R307 Q8WXE1
PDB IDs		4WHJ 4X0R 5UOT	4IGK 4NB3 5YZ0
Enriched GO Terms of Interacting Partners?
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