MSH5 and MSH4

Number of citations of the paper that reports this interaction (PubMedID 10029069)
27

Data Source:
HPRD (two hybrid, in vitro)

		MSH5	MSH4
Description		mutS homolog 5	mutS homolog 4
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nuclear Chromosome Nucleus	Nuclear Chromosome Synaptonemal Complex Nucleus Recombination Nodule
	Molecular Function	Protein Binding DNA-dependent ATPase Activity Mismatched DNA Binding	DNA Binding Protein Binding DNA-dependent ATPase Activity Mismatched DNA Binding
	Biological Process	Mismatch Repair Reciprocal Meiotic Recombination	Resolution Of Meiotic Recombination Intermediates Ovarian Follicle Development Mismatch Repair Synapsis Reciprocal Meiotic Recombination Spermatogenesis Female Gamete Generation
Pathways		Meiotic recombination	Meiotic recombination
Drugs
Diseases
GWAS		Asthma ( 31619474) Asthma (childhood onset) ( 31619474) Asthma and major depressive disorder ( 31619474) Autism spectrum disorder or schizophrenia ( 28540026) Blond vs. brown/black hair color ( 30531825) Blood protein levels ( 28240269) Clozapine-induced agranulocytosis/granulocytopenia in treatment-resistant schizophrenia ( 26876947) Cutaneous lupus erythematosus ( 25827949) Inflammatory bowel disease ( 28067908) Lung cancer ( 18978787) Medication use (anilides) ( 31015401) Menopause (age at onset) ( 26414677) Pulse pressure ( 27618448) Systemic lupus erythematosus ( 26316170) Systolic blood pressure ( 27618448) Takayasu arteritis ( 25604533) Ulcerative colitis ( 24837172 28067908)	Attention function in attention deficit hyperactive disorder ( 26174813) Daytime sleep phenotypes ( 27126917) Serum metabolite levels ( 23093944)
Interacting Genes		2 interacting genes: MSH4 NEU1	9 interacting genes: ACADM DMC1 EIF3F MLH1 MLH3 MSH5 RAD51 RPA1 VBP1
Entrez ID		4439	4438
HPRD ID		04544	03658
Ensembl ID		ENSG00000204410	ENSG00000057468
Uniprot IDs		A0A024RCM1 A0A024RCV6 O43196	O15457
PDB IDs
Enriched GO Terms of Interacting Partners?
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