ASL and QARS1

Number of citations of the paper that reports this interaction (PubMedID 16189514)
1016

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		ASL	QARS1
Description		argininosuccinate lyase	glutaminyl-tRNA synthetase 1
Image
GO Annotations	Cellular Component	Cytoplasm Cytosol Extracellular Exosome	Cytoplasm Mitochondrial Matrix Cytosol Aminoacyl-tRNA Synthetase Multienzyme Complex Protein-containing Complex
	Molecular Function	Argininosuccinate Lyase Activity Protein Binding Identical Protein Binding	Glutamine-tRNA Ligase Activity Protein Kinase Inhibitor Activity Protein Binding ATP Binding Protein Kinase Binding
	Biological Process	Urea Cycle Arginine Biosynthetic Process Via Ornithine	TRNA Aminoacylation For Protein Translation Glutaminyl-tRNA Aminoacylation Negative Regulation Of Protein Kinase Activity Brain Development Negative Regulation Of Stress-activated MAPK Cascade Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Apoptotic Signaling Pathway
Pathways		Urea cycle	Selenoamino acid metabolism Cytosolic tRNA aminoacylation Mitochondrial tRNA aminoacylation
Drugs		L-Arginine Argininosuccinate 2-(N-Morpholino)-Ethanesulfonic Acid
Diseases		Argininosuccinic aciduria (ARGINSA); Argininosuccinate lyase deficiency
GWAS
Interacting Genes		9 interacting genes: CLK1 CSNK2A2 FBP1 HMOX1 MCMBP NTAQ1 OVGP1 QARS1 SRPK2	39 interacting genes: ACTN2 ANXA7 APP ASL CDK4 CDKN1A CLTC CPNE3 DPPA4 DTX2 DUSP11 FAM118B GADD45A GSK3B H2AX IRF1 KCNE3 KLC3 LAMTOR3 LZTS2 MAP3K5 NLGN3 PIK3R3 PIN1 PRRC2A RARS1 RNF11 SMAD9 SMN1 STK3 TCF12 TK1 TLE5 TRAF2 TRAF4 TRIP13 TSC22D1 TTR VPS37B
Entrez ID		435	5859
HPRD ID		01948	07223
Ensembl ID		ENSG00000126522	ENSG00000172053
Uniprot IDs		A0A024RDL8 A0A0S2Z316 P04424	B7Z840 P47897
PDB IDs		1AOS 1K62	4R3Z 4YE6 4YE8 4YE9
Enriched GO Terms of Interacting Partners?
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