CD200 and HCRTR2

Number of citations of the paper that reports this interaction (PubMedID 10981966)
119

Data Source:
HPRD (in vivo)

		CD200	HCRTR2
Description		CD200 molecule	hypocretin receptor 2
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Membrane Axon Neuron Projection Neuronal Cell Body Cell Body	Cell Plasma Membrane Integral Component Of Plasma Membrane Synapse
	Molecular Function	Protein Binding Protein Binding Involved In Heterotypic Cell-cell Adhesion Glycosylated Region Protein Binding	G Protein-coupled Receptor Activity Neuropeptide Receptor Activity Orexin Receptor Activity Peptide Hormone Binding Peptide Binding
	Biological Process	Negative Regulation Of Leukocyte Activation Negative Regulation Of Cell Proliferation Negative Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of CREB Transcription Factor Activity Heterotypic Cell-cell Adhesion Negative Regulation Of Macrophage Activation Regulation Of Immune Response Positive Regulation Of Transforming Growth Factor Beta Production Cell-cell Adhesion Positive Regulation Of Arginase Activity Positive Regulation Of Protein-glutamine Gamma-glutamyltransferase Activity Regulation Of Neuroinflammatory Response Negative Regulation Of Neuroinflammatory Response Negative Regulation Of Interleukin-6 Secretion Negative Regulation Of Neuron Death Negative Regulation Of Matrix Metallopeptidase Secretion Negative Regulation Of Macrophage Migration Negative Regulation Of T Cell Migration	G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Neuropeptide Signaling Pathway Chemical Synaptic Transmission Feeding Behavior Regulation Of Circadian Sleep/wake Cycle, Wakefulness Circadian Sleep/wake Cycle Process Cellular Response To Hormone Stimulus Regulation Of Cytosolic Calcium Ion Concentration
Pathways		Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	Orexin and neuropeptides FF and QRFP bind to their respective receptors G alpha (q) signalling events
Drugs			Suvorexant
Diseases
GWAS		Blood protein levels ( 30072576) Cognitive decline rate in late mild cognitive impairment ( 26252872) Eosinophil counts ( 27863252) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 27863252) Neutrophil percentage of granulocytes ( 27863252) Sum eosinophil basophil counts ( 27863252)	Blood urea nitrogen levels ( 31152163) Chronotype ( 30696823 27494321) Excessive daytime sleepiness ( 27992416) Fasting glucose change (long-term) ( 31263163) HIV-1 control ( 20041166) Menarche (age at onset) ( 25231870) Morning person ( 30696823) Morning vs. evening chronotype ( 26835600 27494321) Severity of nausea and vomiting of pregnancy ( 29563502) Sleep duration (short sleep) ( 30846698) Sleep traits (multi-trait analysis) ( 27992416)
Interacting Genes		3 interacting genes: CD200R1 HCRTR2 HUS1	2 interacting genes: CD200 HCRT
Entrez ID		4345	3062
HPRD ID		01124	08374
Ensembl ID		ENSG00000091972	ENSG00000137252
Uniprot IDs		B4DDZ6 F8W7G1 P41217	O43614 S4X0W3
PDB IDs			4S0V 5WQC 5WS3
Enriched GO Terms of Interacting Partners?
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