ASIP and MC2R

Number of citations of the paper that reports this interaction (PubMedID 9058374)
25

Data Source:
HPRD (in vitro)

		ASIP	MC2R
Description		agouti signaling protein	melanocortin 2 receptor
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Space Cell	Cytoplasm Plasma Membrane Integral Component Of Plasma Membrane
	Molecular Function	Signaling Receptor Binding Type 3 Melanocortin Receptor Binding Type 4 Melanocortin Receptor Binding	Melanocortin Receptor Activity Corticotropin Receptor Activity Protein Binding
	Biological Process	Generation Of Precursor Metabolites And Energy Signal Transduction Cell-cell Signaling Adult Feeding Behavior Hormone-mediated Signaling Pathway Melanosome Transport Melanosome Organization Regulation Of Molecular Function, Epigenetic Melanin Biosynthetic Process Positive Regulation Of Melanin Biosynthetic Process Genetic Imprinting	Placenta Development G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Neuropeptide Signaling Pathway
Pathways			Peptide ligand-binding receptors G alpha (s) signalling events Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) ADORA2B mediated anti-inflammatory cytokines production
Drugs			Tetracosactide Corticotropin
Diseases			Adrenal carcinoma
GWAS		Blood protein levels ( 30072576 29875488) Breast cancer ( 22976474) Burning and freckling ( 18488028) Facial pigmentation ( 25705849) Freckles ( 18488028) Freckling ( 20585627) Hair color ( 20585627) Low tan response ( 29739929) Melanoma ( 21983787 28212542) Nevus count or cutaneous melanoma ( 30429480) Non-melanoma skin cancer ( 29739929) Red vs. non-red hair color ( 18488028) Skin colour saturation ( 25963972) Skin pigmentation ( 28300201) Skin sensitivity to sun ( 25963972 18488028) Tanning ( 23548203) Vitiligo ( 27723757)	Negative urgency ( 30718321) Parental longevity (both parents in top 10%) ( 29227965) Parental longevity (combined parental attained age, Martingale residuals) ( 29227965)
Interacting Genes		6 interacting genes: F11R MC1R MC2R MC3R MC4R MC5R	2 interacting genes: ASIP POMC
Entrez ID		434	4158
HPRD ID		02562	06304
Ensembl ID		ENSG00000101440	ENSG00000185231
Uniprot IDs		P42127	Q01718
PDB IDs		1Y7J 1Y7K 2IQW 2KZA 2L1J
Enriched GO Terms of Interacting Partners?
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