AFDN and RALGDS

Number of citations of the paper that reports this interaction (PubMedID 10545207)
24

Data Source:
HPRD (two hybrid)

		AFDN	RALGDS
Description		afadin, adherens junction formation factor	ral guanine nucleotide dissociation stimulator
Image
GO Annotations	Cellular Component	Nucleoplasm Cytosol Plasma Membrane Cell-cell Junction Adherens Junction Nuclear Speck Cell Junction Cell-cell Contact Zone Pore Complex Tight Junction	Nucleus Cytosol Brush Border
	Molecular Function	Protein Binding Protein C-terminus Binding Ras GTPase Binding Cadherin Binding Cell Adhesion Molecule Binding Actin Filament Binding	Guanyl-nucleotide Exchange Factor Activity Protein Binding GTPase Regulator Activity
	Biological Process	Cell Adhesion Signal Transduction Cell-cell Signaling Positive Regulation Of Gene Expression Positive Regulation Of Cell-cell Adhesion Negative Regulation Of Cell Migration Regulation Of Protein Localization Adherens Junction Organization Positive Regulation Of GTPase Activity Cell-cell Adhesion Mediated By Cadherin Pore Complex Assembly Establishment Of Protein Localization To Plasma Membrane Bicellular Tight Junction Assembly Establishment Of Endothelial Intestinal Barrier Positive Regulation Of Cell-cell Adhesion Mediated By Cadherin	Ras Protein Signal Transduction Regulation Of Catalytic Activity
Pathways			p38MAPK events p38MAPK events
Drugs		(5R)-2-SULFANYL-5-[4-(TRIFLUOROMETHYL)BENZYL]-1,3-THIAZOL-4-ONE
Diseases
GWAS		Number of alcoholic drinks required to feel an effect (long-term average) ( 31270906)	Blood protein levels in cardiovascular risk ( 28369058)
Interacting Genes		37 interacting genes: BCR CTNNA1 EPHA7 EPHB2 EPHB3 EPHB6 F11R HRAS JAG1 LMO2 MRAS NECTIN1 NECTIN2 NECTIN3 NECTIN4 NRXN1 NRXN2 NRXN3 PFN1 PICK1 RALGDS RAP1A RAP1GAP RAP2A RIN1 RIT1 RIT2 RRAS RRAS2 SMAD2 SORBS1 SORBS2 SSX2IP TJP1 USP9X YWHAB YWHAG	23 interacting genes: AFDN ARRB1 ARRB2 CD68 CNKSR1 HRAS KRAS LRPAP1 MAPK3 MRAS NF2 PDPK1 RAP1A RAP1B RAP1GAP RAP2A RAP2B RAPGEF2 RIN1 RIT1 RIT2 RRAS RRAS2
Entrez ID		4301	5900
HPRD ID		01164	03371
Ensembl ID		ENSG00000130396	ENSG00000160271
Uniprot IDs		A8MQ02 G1UI22 J3KN01 P55196	Q12967 Q8N4Y1
PDB IDs		1T2M 1XZ9 2AIN 2EXG 5A6C	1RAX 2B3A 2RGF 3KH0
Enriched GO Terms of Interacting Partners?
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