MITF and OTX2

Number of citations of the paper that reports this interaction (PubMedID 12663655)
53

Data Source:
HPRD (in vitro)

		MITF	OTX2
Description		melanocyte inducing transcription factor	orthodenticle homeobox 2
Image			No pdb structure
GO Annotations	Cellular Component	Nuclear Chromatin Nucleus Nucleoplasm Protein-containing Complex	Nuclear Chromatin Nucleus Growth Cone Protein-containing Complex
	Molecular Function	RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Chromatin Binding Protein Binding Protein Dimerization Activity E-box Binding	RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Protein Binding Eukaryotic Initiation Factor 4E Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Transcription, DNA-templated Regulation Of Transcription, DNA-templated Positive Regulation Of Gene Expression Osteoclast Differentiation Melanocyte Differentiation Negative Regulation Of Cell Migration Regulation Of Cell Proliferation Camera-type Eye Development Canonical Wnt Signaling Pathway Involved In Negative Regulation Of Apoptotic Process Cell Fate Commitment Regulation Of Osteoclast Differentiation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Bone Remodeling Protein-containing Complex Assembly Positive Regulation Of DNA-templated Transcription, Initiation Regulation Of RNA Biosynthetic Process	Axon Guidance Regulation Of Smoothened Signaling Pathway Forebrain Development Midbrain Development Positive Regulation Of Embryonic Development Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Protein-containing Complex Assembly Dopaminergic Neuron Differentiation Primitive Streak Formation Positive Regulation Of Gastrulation
Pathways		SUMOylation of transcription factors
Drugs
Diseases		Ocular albinism; Ocular albinism, type I (OA1); Waardenburg syndrome, type II (WS2-OA) Waardenburg syndrome (WS) Malignant melanoma	Anophthalmia and microphthalmia (A/M) Septo-optic dysplasia
GWAS		Blond vs. brown/black hair color ( 30531825) Chronotype ( 30696823) Circulating fibroblast growth factor 23 levels ( 30217807) Hematocrit ( 27863252) Hemoglobin concentration ( 27863252) Pulse pressure ( 27841878) QRS complex (12-leadsum) ( 27659466) Red blood cell count ( 27863252) Severe influenza A (H1N1) infection ( 26379185) Systolic blood pressure ( 27841878)	Alcohol consumption ( 31358974) Alcohol consumption (drinks per week) ( 30643258) Chronotype ( 30696823) Moderate-to-late spontaneous preterm birth ( 31194736)
Interacting Genes		29 interacting genes: APP CTNNB1 EBP EP300 FBXO7 FOS GSK3B HINT1 HK3 LEF1 MAPK1 MAPK14 MARK3 OTX2 PATZ1 PAX3 PAX6 PIAS1 PIAS2 PIAS3 PSMD14 RPS6KA1 SPI1 STUB1 SUMO1 TFE3 TFEB TFEC UBE2I	10 interacting genes: APP ATXN1 CDK4 DMBX1 FOXA2 LHX1 MITF SMARCB1 TLE4 ZDHHC17
Entrez ID		4286	5015
HPRD ID		01138	07190
Ensembl ID		ENSG00000187098	ENSG00000165588
Uniprot IDs		A0A087WXU1 B4DNC7 O75030 Q8WYR3	F1T0C9 F1T0D0 F1T0D1 P32243
PDB IDs		4C7N
Enriched GO Terms of Interacting Partners?
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