MEP1B and GRP

Number of citations of the paper that reports this interaction (PubMedID 11278902)
40

Data Source:
HPRD (in vitro)

		MEP1B	GRP
Description		meprin A subunit beta	gastrin releasing peptide
Image
GO Annotations	Cellular Component	Extracellular Region Integral Component Of Plasma Membrane Meprin A Complex	Extracellular Region Extracellular Space Secretory Granule Lumen
	Molecular Function	Metalloendopeptidase Activity Protein Binding Zinc Ion Binding Identical Protein Binding	Signaling Receptor Binding Neuropeptide Hormone Activity
	Biological Process	Proteolysis Inflammatory Response Toxin Transport	Signal Transduction G Protein-coupled Receptor Signaling Pathway Neuropeptide Signaling Pathway Social Behavior Psychomotor Behavior Response To External Biotic Stimulus Positive Regulation Of Peptide Hormone Secretion Positive Regulation Of Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway
Pathways			Peptide ligand-binding receptors Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) G alpha (q) signalling events
Drugs
Diseases
GWAS		Metabolite levels ( 23823483) TRAIL levels ( 27989323)	BMI (adjusted for smoking behaviour) ( 28443625) BMI in non-smokers ( 28443625) Body mass index ( 25673413) Body mass index (joint analysis main effects and smoking interaction) ( 28443625) Medication use (drugs used in diabetes) ( 31015401) Pancreatic cancer ( 29422604 26098869) Pancreatic ductal adenocarcinoma ( 30541042) Triglyceride levels x thiazide or thiazide-like diuretics use interaction ( 31806883) Type 2 diabetes ( 30297969)
Interacting Genes		12 interacting genes: CCK FN1 GAST GCG GRP MEP1A NPY OS9 PRKACA PRKCD PYY SCT	4 interacting genes: DPP4 GRPR MEP1A MEP1B
Entrez ID		4225	2922
HPRD ID		02667	08845
Ensembl ID		ENSG00000141434	ENSG00000134443
Uniprot IDs		J3QKX5 Q16820	A0A140VJM7 P07492
PDB IDs		4GWM 4GWN	2N0B 2N0C 2N0D 2N0E 2N0F 2N0G 2N0H
Enriched GO Terms of Interacting Partners?
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