ART4 and UPF2

Number of citations of the paper that reports this interaction (PubMedID 15231747)
56

Data Source:
BioGRID (two hybrid)

		ART4	UPF2
Description		ADP-ribosyltransferase 4 (Dombrock blood group)	UPF2 regulator of nonsense mediated mRNA decay
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Plasma Membrane Membrane Anchored Component Of Membrane	Nucleus Cytoplasm Cytosol Polysome Exon-exon Junction Complex Cytoplasmic Ribonucleoprotein Granule Perinuclear Region Of Cytoplasm
	Molecular Function	NAD+ ADP-ribosyltransferase Activity NAD(P)+-protein-arginine ADP-ribosyltransferase Activity	RNA Binding Protein Binding Telomeric DNA Binding
	Biological Process	Protein ADP-ribosylation Arginine Metabolic Process Peptidyl-arginine ADP-ribosylation	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Liver Development MRNA Export From Nucleus Animal Organ Regeneration
Pathways		Post-translational modification: synthesis of GPI-anchored proteins	Regulation of expression of SLITs and ROBOs Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
Drugs
Diseases
GWAS		Blood protein levels ( 30072576 29875488) Hand grip strength ( 29691431)	Diverticular disease ( 30177863)
Interacting Genes		2 interacting genes: APP UPF2	75 interacting genes: ABCF2 AGPAT1 ART4 ATP1B3 BLM CALR CENPU CIZ1 COMTD1 CYBA DCP1B DCP2 DPF2 E4F1 EIF1 EIF4A1 EIF4G1 ENO1 EXOSC1 EXOSC10 EXOSC4 EXOSC6 EXOSC8 GADD45GIP1 HBZ HMGA1 HS3ST3A1 HSF2BP ITGB1 KRT18 LDHA LSM1 MAP1A MAP1LC3B MIF MRPL40 MTERF3 MTREX MYB NDUFA7 NOB1 NOMO1 NOP53 PHB2 PITX1 PUF60 RNPS1 RPL13 RPL5 RPL8 RPS15 RPS25 RPS6 RPS7 RRP7A RSRC2 SERBP1 SERF2 SMG1 SUMO3 TK1 TNNI2 TOP3B TUBB2A TYMS UPF1 UPF3B WNK1 XRN1 XRN2 ZBTB48 ZFP36 ZGPAT ZNF408 ZNF44
Entrez ID		420	26019
HPRD ID		04364	10405
Ensembl ID		ENSG00000111339	ENSG00000151461
Uniprot IDs		Q93070	Q9HAU5
PDB IDs			1UW4 2WJV 4CEK 4CEM
Enriched GO Terms of Interacting Partners?
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