MCC and NFKBIB

Number of citations of the paper that reports this interaction (PubMedID 14743216)
300

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo)

		MCC	NFKBIB
Description		MCC regulator of WNT signaling pathway	NFKB inhibitor beta
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Plasma Membrane Lamellipodium Cytoplasmic Ribonucleoprotein Granule	Nucleus Cytosol
	Molecular Function	Protein Binding Signaling Receptor Activity	Transcription Coactivator Activity Protein Binding
	Biological Process	Signal Transduction Negative Regulation Of Epithelial Cell Migration Wnt Signaling Pathway Establishment Of Protein Localization Negative Regulation Of Epithelial Cell Proliferation Negative Regulation Of Canonical Wnt Signaling Pathway	Transcription, DNA-templated Signal Transduction Cellular Response To Lipopolysaccharide Positive Regulation Of Nucleic Acid-templated Transcription
Pathways			Activation of NF-kappaB in B cells RIP-mediated NFkB activation via ZBP1 TAK1 activates NFkB by phosphorylation and activation of IKKs complex TRAF6 mediated NF-kB activation
Drugs
Diseases
GWAS		Brain cytoarchitecture ( 20308991) Cerebral amyloid angiopathy ( 25188341) Emphysema annual change measurement in smokers (adjusted lung density) ( 31324189) Height ( 31562340) Metabolite levels ( 23823483) Neurofibrillary tangles ( 31497858)
Interacting Genes		10 interacting genes: APP CBX5 CSNK1E DYNC1I1 ERBIN GTF2E2 MTNR1A NEK2 NFKBIB STOML2	41 interacting genes: APP BAK1 BTRC CD3EAP CDC25A CHUK CSNK2A1 CUL1 DNAJA3 ESR2 FHL3 GIT2 IKBKB IKBKG KPNA2 LRPPRC MCC MTIF2 NCOR2 NFKB1 NFKB2 NFKBIA NGFR NKIRAS1 NKIRAS2 PDCD2 POLR1A POLR1B POLR1C POLR1D POLR1E POLR2H POLR2L PPARG RASAL2 REL RELA RXRA SKP1 TSPAN1 VPS52
Entrez ID		4163	4793
HPRD ID		01157	07260
Ensembl ID		ENSG00000171444	ENSG00000104825
Uniprot IDs		P23508	G5E9C2 Q15653
PDB IDs		6MTU
Enriched GO Terms of Interacting Partners?
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