MAPT and ABL1

Number of citations of the paper that reports this interaction (PubMedID 16014719)
55

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo)

		MAPT	ABL1
Description		microtubule associated protein tau	ABL proto-oncogene 1, non-receptor tyrosine kinase
Image
GO Annotations	Cellular Component	Extracellular Region Cell Nucleus Cytoplasm Mitochondrion Cytosol Microtubule Plasma Membrane Microtubule Cytoskeleton Membrane Nuclear Speck Axon Dendrite Growth Cone Axolemma Nuclear Periphery Cytoplasmic Ribonucleoprotein Granule Somatodendritic Compartment Neuron Projection Neuronal Cell Body Dendritic Spine Cell Body Main Axon Membrane Raft Tubulin Complex Glial Cell Projection Neurofibrillary Tangle Axon Cytoplasm	Cell Nucleus Nucleoplasm Nucleolus Cytoplasm Mitochondrion Cytosol Actin Cytoskeleton Nuclear Body Dendrite Cell Leading Edge Nuclear Membrane Protein-containing Complex Neuronal Cell Body Perinuclear Region Of Cytoplasm Postsynapse
	Molecular Function	DNA Binding AT DNA Binding Double-stranded DNA Binding Single-stranded DNA Binding RNA Binding Actin Binding Protein Binding Microtubule Binding SH3 Domain Binding Enzyme Binding Protein Kinase Binding Protein Binding, Bridging Apolipoprotein Binding Dynactin Binding Phosphatidylinositol Binding Identical Protein Binding Sequence-specific DNA Binding Chaperone Binding Protein Phosphatase 2A Binding Hsp90 Protein Binding Lipoprotein Particle Binding Histone-dependent DNA Binding Microtubule Lateral Binding Phosphatidylinositol Bisphosphate Binding	Magnesium Ion Binding Four-way Junction DNA Binding Bubble DNA Binding Phosphotyrosine Residue Binding DNA Binding Transcription Coactivator Activity Actin Monomer Binding Nicotinate-nucleotide Adenylyltransferase Activity Protein Kinase Activity Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Protein Kinase C Binding Protein Binding ATP Binding Protein C-terminus Binding Kinase Activity SH3 Domain Binding Syntaxin Binding Manganese Ion Binding Neuropilin Binding SH2 Domain Binding Ephrin Receptor Binding Actin Filament Binding Mitogen-activated Protein Kinase Binding Proline-rich Region Binding Supercoiled DNA Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Microtubule Cytoskeleton Organization Microglial Cell Activation Internal Protein Amino Acid Acetylation Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Cell-cell Signaling Memory Response To Lead Ion Regulation Of Autophagy Negative Regulation Of Gene Expression Negative Regulation Of Mitochondrial Membrane Potential RRNA Metabolic Process Axonal Transport Of Mitochondrion Central Nervous System Neuron Development Regulation Of Microtubule Polymerization Or Depolymerization Regulation Of Microtubule Polymerization Positive Regulation Of Microtubule Polymerization Cytoplasmic Microtubule Organization Neuron Projection Development Positive Regulation Of Superoxide Anion Generation Regulation Of Chromosome Organization Negative Regulation Of Kinase Activity Stress Granule Assembly Cellular Response To Heat Cellular Response To Reactive Oxygen Species Positive Regulation Of Axon Extension Microtubule Polymerization Astrocyte Activation Regulation Of Synaptic Plasticity Intracellular Distribution Of Mitochondria Generation Of Neurons Synapse Organization Regulation Of Calcium-mediated Signaling Protein Polymerization Axon Development Regulation Of Microtubule Cytoskeleton Organization Plus-end-directed Organelle Transport Along Microtubule Regulation Of Mitochondrial Fission Negative Regulation Of Mitochondrial Fission Supramolecular Fiber Organization Axonal Transport Regulation Of Cellular Response To Heat Regulation Of Long-term Synaptic Depression Positive Regulation Of Neuron Death Positive Regulation Of Protein Localization To Synapse Neurofibrillary Tangle Assembly Negative Regulation Of Establishment Of Protein Localization To Mitochondrion Positive Regulation Of Cellular Protein Localization Negative Regulation Of Tubulin Deacetylation Positive Regulation Of Diacylglycerol Kinase Activity Amyloid Fibril Formation Cellular Response To Nerve Growth Factor Stimulus Cellular Response To Brain-derived Neurotrophic Factor Stimulus Regulation Of Response To DNA Damage Stimulus	Mitotic Cell Cycle Neural Tube Closure B-1 B Cell Homeostasis Positive Regulation Of Protein Phosphorylation B Cell Proliferation Involved In Immune Response Transitional One Stage B Cell Differentiation Mismatch Repair Regulation Of Transcription, DNA-templated Cellular Protein Modification Process Protein Phosphorylation Endocytosis Autophagy Cellular Response To DNA Damage Stimulus DNA Damage Induced Protein Phosphorylation Response To Oxidative Stress Cell Cycle Arrest Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Integrin-mediated Signaling Pathway Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Post-embryonic Development Regulation Of Autophagy Positive Regulation Of Endothelial Cell Migration Peptidyl-tyrosine Phosphorylation Cerebellum Morphogenesis Negative Regulation Of Cell-cell Adhesion Microspike Assembly Actin Cytoskeleton Organization Regulation Of Endocytosis Regulation Of Cell Adhesion Negative Regulation Of BMP Signaling Pathway Regulation Of Axon Extension Regulation Of Microtubule Polymerization Regulation Of Cdc42 Protein Signal Transduction Regulation Of Actin Cytoskeleton Organization Positive Regulation Of Osteoblast Proliferation Substrate Adhesion-dependent Cell Spreading Cellular Response To Oxidative Stress Platelet-derived Growth Factor Receptor-beta Signaling Pathway Peptidyl-tyrosine Autophosphorylation Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Neuropilin Signaling Pathway Signal Transduction In Response To DNA Damage Regulation Of Apoptotic Process Positive Regulation Of Apoptotic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Negative Regulation Of I-kappaB Kinase/NF-kappaB Signaling Endothelial Cell Migration Establishment Of Protein Localization Regulation Of T Cell Differentiation Negative Regulation Of Mitotic Cell Cycle Positive Regulation Of Mitotic Cell Cycle Positive Regulation Of Transcription By RNA Polymerase II Alpha-beta T Cell Differentiation Protein Autophosphorylation Spleen Development Thymus Development Collateral Sprouting Positive Regulation Of Peptidyl-tyrosine Phosphorylation Activated T Cell Proliferation T Cell Receptor Signaling Pathway B Cell Receptor Signaling Pathway Neuromuscular Process Controlling Balance Positive Regulation Of Muscle Cell Differentiation Positive Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Positive Regulation Of Oxidoreductase Activity Negative Regulation Of Ubiquitin-protein Transferase Activity Positive Regulation Of Stress Fiber Assembly Mitochondrial Depolarization Positive Regulation Of Focal Adhesion Assembly Bergmann Glial Cell Differentiation Neuroepithelial Cell Differentiation Cellular Response To Hydrogen Peroxide Negative Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of ERK1 And ERK2 Cascade DNA Conformation Change Cellular Response To Lipopolysaccharide Negative Regulation Of Protein Serine/threonine Kinase Activity Cardiovascular System Development Positive Regulation Of Cell Migration Involved In Sprouting Angiogenesis Actin Filament Branching Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Positive Regulation Of Interleukin-2 Secretion Negative Regulation Of Long-term Synaptic Potentiation Negative Regulation Of Phospholipase C Activity Positive Regulation Of Neuron Death Regulation Of Hematopoietic Stem Cell Differentiation Positive Regulation Of Interferon-gamma Secretion Regulation Of Extracellular Matrix Organization Cellular Response To Dopamine Positive Regulation Of Microtubule Binding Positive Regulation Of Actin Filament Binding Regulation Of Modification Of Synaptic Structure Positive Regulation Blood Vessel Branching Activation Of Protein Kinase C Activity Positive Regulation Of Wnt Signaling Pathway, Planar Cell Polarity Pathway Regulation Of Cell Motility Regulation Of Actin Cytoskeleton Reorganization Positive Regulation Of Actin Cytoskeleton Reorganization Negative Regulation Of Endothelial Cell Apoptotic Process Negative Regulation Of Cellular Senescence Regulation Of Response To DNA Damage Stimulus
Pathways		Caspase-mediated cleavage of cytoskeletal proteins	Regulation of actin dynamics for phagocytic cup formation Role of ABL in ROBO-SLIT signaling Role of ABL in ROBO-SLIT signaling Myogenesis Myogenesis RHO GTPases Activate WASPs and WAVEs HDR through Single Strand Annealing (SSA) Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Cyclin D associated events in G1 RUNX1 regulates transcription of genes involved in differentiation of HSCs RUNX2 regulates osteoblast differentiation FCGR3A-mediated phagocytosis Factors involved in megakaryocyte development and platelet production
Drugs		Lansoprazole Astemizole Paclitaxel Docetaxel	ATP Imatinib Dasatinib N-[4-Methyl-3-[[4-(3-Pyridinyl)-2-Pyrimidinyl]Amino]Phenyl]-3-Pyridinecarboxamide Nilotinib XL228 Bosutinib 2-{[(6-OXO-1,6-DIHYDROPYRIDIN-3-YL)METHYL]AMINO}-N-[4-PROPYL-3-(TRIFLUOROMETHYL)PHENYL]BENZAMIDE 1-[4-(PYRIDIN-4-YLOXY)PHENYL]-3-[3-(TRIFLUOROMETHYL)PHENYL]UREA Myristic acid 6-(2,6-DICHLOROPHENYL)-2-{[3-(HYDROXYMETHYL)PHENYL]AMINO}-8-METHYLPYRIDO[2,3-D]PYRIMIDIN-7(8H)-ONE 5-[3-(2-METHOXYPHENYL)-1H-PYRROLO[2,3-B]PYRIDIN-5-YL]-N,N-DIMETHYLPYRIDINE-3-CARBOXAMIDE 2-amino-5-[3-(1-ethyl-1H-pyrazol-5-yl)-1H-pyrrolo[2,3-b]pyridin-5-yl]-N,N-dimethylbenzamide Regorafenib Ponatinib Brigatinib Radotinib
Diseases		Amyotrophic lateral sclerosis (ALS); Lou Gehrig's disease Frontotemporal lobar degeneration (FTLD), including: Pick disease of brain; Frontotemporal dementia (FTD); Ubiquitin-positive frontotemporal dementia (UP-FTD); Progressive supranuclear palsy type 1 (PSNP1); Inclusion body myopathy with early-onset paget disease and frontotemporal dementia (IBMPFD); Frontotemporal dementia, chromosome 3-linked (FTD3) Progressive supranuclear palsy (PSP); Steele-Richardson-Olszewski syndrome	Chronic myeloid leukemia (CML) Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia)
GWAS		Alcohol consumption ( 31358974) Alcohol consumption (drinks per week) ( 30643258) Alcohol use disorder (consumption score) ( 30336701) Alcohol use disorder (total score) ( 30336701) Alzheimer's disease ( 31473137) Alzheimer's disease in APOE e4- carriers ( 25778476) Atrial fibrillation ( 29892015) Cognitive ability ( 29186694) Cognitive ability (MTAG) ( 29186694) Cognitive performance (processing speed) ( 31598132) Corticobasal degeneration ( 26077951) Experiencing mood swings ( 29500382) Feeling hurt ( 29500382) General cognitive ability ( 29844566) General factor of neuroticism ( 30867560) Handedness (Left-handed vs. non-left-handed) ( 31504236) Handedness (left-handed vs. right-handed) ( 31504236) Handedness (non-right-handed vs right-handed) ( 31504236) Head circumference (infant) ( 22504419) Headache ( 29397368) Household income ( 31844048) Household income (MTAG) ( 31844048) Idiopathic pulmonary fibrosis ( 24429156) Interstitial lung disease ( 23583980) Intracranial volume ( 22504418) Lumbar spine bone mineral density ( 22504420) Male-pattern baldness ( 29146897 28196072) Medication use (anilides) ( 31015401) Mood instability ( 31168069) Multiple system atrophy ( 27629089) Neuroticism ( 29255261) Parkinson's disease ( 20711177 21292315 19915575 25064009 31660654 24842889 28892059 22438815 20070850 21044948 24511991 21738487) Plasma t-tau levels ( 28100725) Primary biliary cirrhosis ( 22961000) Progressive supranuclear palsy ( 30089514 21685912 31059154) QRS complex (12-leadsum) ( 27659466) Reaction time ( 29844566) Subcortical brain region volumes ( 25607358)	Coronary artery calcified atherosclerotic plaque score in type 2 diabetes ( 29221444) Response to amphetamines ( 22952603)
Interacting Genes		128 interacting genes: AATF ABL1 ACTA1 ACTB ACTG1 AKT1 AMPH APOE APP ARHGEF40 BAG1 BRSK1 BRSK2 CALM1 CAMK2A CAPN1 CAPN2 CASP1 CASP3 CASP6 CASP7 CASP8 CDK1 CDK2 CDK5 CHEK1 CHEK2 CREBBP CSNK1A1 CSNK1D CSNK2A1 CTSD DUSP1 DYRK1A DYRK2 EGFR EP300 F2 FKBP1A FKBP5 FYN GRB2 GSK3A GSK3B HDAC6 HOOK3 HSP90AA1 HSPA8 HSPB1 HTRA1 LCK LGMN LRRK2 MAP2K7 MAPK1 MAPK10 MAPK11 MAPK12 MAPK13 MAPK14 MAPK3 MAPK8 MAPK9 MARCHF7 MARK1 MARK2 MARK3 MARK4 MASP1 MELK NPEPPS OGT OTUB1 PACSIN1 PDIA2 PEG10 PHKG1 PIK3R1 PIN1 PKN1 PLCG1 PPP1CA PPP1CB PPP1CC PPP2CA PPP2CB PPP2R5A PPP5C PRKACA PRKCA PRKCB PRKCD PRKCE PRKCG PRKCI PRKCZ PSEN1 PTK2B PTPA PWP2 RPS6KA1 RPS6KA3 RPS6KA5 RPS6KB1 S100B SIK1 SIRT1 SNCA SPTB SQSTM1 SRC SRPK1 SRPK2 STAU1 STUB1 STXBP1 SYK TRAF6 TTBK1 TUBA1B TUBA4A TUBB TUBB3 UBB UBE2D2 USP9Y YWHAB YWHAZ	158 interacting genes: ABI1 ABI2 ABL2 ACTA1 ADAM15 ANAPC15 ANKRA2 APBB1 APP ARHGAP17 ATM ATR BCAR1 BCR BIN1 BRCA1 BTK C3 CABLES1 CABLES2 CASP9 CAT CAV1 CBL CCND2 CD19 CDK1 CDK5 CDKN1A CDKN1B CDON CREB1 CRK CRKL CTNND2 DAPK1 DDB1 DDB2 DENND2B DOK1 DOK2 DOK3 DVL2 EMD ENAH EP300 EPHA3 EPHB2 ERBB2 ERBB3 ERBB4 EVL FBXO7 GPX1 GRB10 GRB2 GRIN2D GTF2F1 HCK HIPK2 HUWE1 INPPL1 JAK1 JAK2 JUN KIT LATS2 LRRK1 MAP4K1 MAP4K5 MAPT MAVS MBP MDM2 MICAL1 MUC1 NCK1 NCOA3 NCSTN NEDD4 NEDD4L NEDD9 NFKBIA NTRK1 PAG1 PAK2 PDE4D PDGFRB PIK3R1 PLCG1 PLEKHA4 PLSCR1 POLR2A PRDX1 PRKD1 PRKDC PSTPIP1 PTPN12 PTPN18 PTPN6 PXN RAD51 RAD51B RAD52 RAD9A RAN RAPGEF1 RASA1 RB1 RFX1 RIN1 ROBO1 ROS1 RYBP SFN SH3BP1 SH3BP2 SHB SHD SHE SLC9A2 SOCS3 SORBS1 SORBS2 SORBS3 SOS2 SPRR2A SPTA1 SPTAN1 SRC SRCIN1 SRPK2 STUB1 TERT TMPO TOPBP1 TP53 TP73 TRAF6 TUB UBC VAV1 WASF1 WASF2 WASL WRNIP1 XPO1 XRCC6 YAP1 YTHDC1 YWHAB YWHAE YWHAG YWHAH YWHAQ YWHAZ ZAP70 ZDHHC16
Entrez ID		4137	25
HPRD ID		01142	01809
Ensembl ID		ENSG00000186868	ENSG00000097007
Uniprot IDs		A0A024R9Y0 A0A024R9Y1 A0A024RA17 A0A024RA19 B3KTM0 P10636	A0A024R8E2 P00519 Q59FK4
PDB IDs		1I8H 2MZ7 2ON9 3OVL 4E0M 4E0N 4E0O 4FL5 4GLR 4NP8 4TQE 4Y32 4Y3B 4Y5I 5DMG 5E2V 5E2W 5HF3 5K7N 5MO3 5MP1 5MP3 5MP5 5N5A 5N5B 5NVB 5O3L 5O3O 5O3T 5V5B 5V5C 5ZIA 5ZV3 6BB4 6CVJ 6CVN 6DC8 6DC9 6DCA 6FBW 6FI5 6GK7 6GK8 6GX5 6H06 6HRE 6HRF 6N4P 6NWP 6NWQ 6ODG 6QJH 6QJM 6QJP 6QJQ	1AB2 1ABL 1AWO 1BBZ 1JU5 1OPL 1ZZP 2ABL 2E2B 2F4J 2FO0 2G1T 2G2F 2G2H 2G2I 2GQG 2HIW 2HYY 2HZ0 2HZ4 2HZI 2O88 2V7A 3CS9 3EG0 3EG1 3EG2 3EG3 3EGU 3K2M 3PYY 3QRI 3QRJ 3QRK 3T04 3UE4 3UYO 4J9B 4J9C 4J9D 4J9E 4J9F 4J9G 4J9H 4J9I 4JJB 4JJC 4JJD 4TWP 4WA9 4XEY 4YC8 4ZOG 5DC0 5DC4 5DC9 5HU9 5MO4 5NP2 5OAZ 6AMV 6AMW 6BL8 6NPE 6NPU 6NPV
Enriched GO Terms of Interacting Partners?
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