SMAD2 and RHOA

Number of citations of the paper that reports this interaction (PubMedID 20195357)
30

Data Source:
BioGRID (pull down)

		SMAD2	RHOA
Description		SMAD family member 2	ras homolog family member A
Image
GO Annotations	Cellular Component	Nuclear Chromatin Nucleus Nucleoplasm Transcription Factor Complex Cytoplasm Cytosol Activin Responsive Factor Complex Protein-containing Complex SMAD Protein Complex Heteromeric SMAD Protein Complex	Nucleus Cytoplasm Endosome Endoplasmic Reticulum Membrane Cytosol Cytoskeleton Plasma Membrane Focal Adhesion Cell Cortex Lamellipodium Cell Junction Axon Midbody Secretory Granule Membrane Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane Cytoplasmic Vesicle Vesicle Cell Division Site Cleavage Furrow Ruffle Membrane Neuron Projection Dendritic Spine Intracellular Membrane-bounded Organelle Apical Junction Complex Extracellular Exosome Cell Periphery Postsynapse Glutamatergic Synapse Ficolin-1-rich Granule Membrane
	Molecular Function	RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding Double-stranded DNA Binding DNA-binding Transcription Factor Activity Transforming Growth Factor Beta Receptor Binding Protein Binding Transcription Factor Binding Phosphatase Binding Transforming Growth Factor Beta Receptor, Pathway-specific Cytoplasmic Mediator Activity Ubiquitin Protein Ligase Binding Activating Transcription Factor Binding Type I Transforming Growth Factor Beta Receptor Binding Enhancer Binding SMAD Binding Metal Ion Binding Tau Protein Binding Co-SMAD Binding I-SMAD Binding R-SMAD Binding Primary MiRNA Binding Disordered Domain Specific Binding	GTPase Activity Protein Binding GTP Binding Myosin Binding GDP Binding Protein Kinase Binding Protein Domain Specific Binding Rho GDP-dissociation Inhibitor Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Ureteric Bud Development In Utero Embryonic Development Endoderm Formation Mesoderm Formation Transforming Growth Factor Beta Receptor Signaling Pathway Common-partner SMAD Protein Phosphorylation SMAD Protein Complex Assembly Zygotic Specification Of Dorsal/ventral Axis Gastrulation Negative Regulation Of Cell Proliferation Response To Glucose Post-embryonic Development Anterior/posterior Pattern Specification Positive Regulation Of Epithelial To Mesenchymal Transition Protein Deubiquitination Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Signal Transduction Involved In Regulation Of Gene Expression Insulin Secretion Lung Development Adrenal Gland Development Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of BMP Signaling Pathway Pancreas Development Primary MiRNA Processing Activin Receptor Signaling Pathway Somatic Stem Cell Population Maintenance Organ Growth Intracellular Signal Transduction Nodal Signaling Pathway Wound Healing Cell Fate Commitment Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Paraxial Mesoderm Morphogenesis Embryonic Foregut Morphogenesis Embryonic Cranial Skeleton Morphogenesis Regulation Of Binding Pericardium Development SMAD Protein Signal Transduction Secondary Palate Development Response To Cholesterol Positive Regulation Of Nodal Signaling Pathway Involved In Determination Of Lateral Mesoderm Left/right Asymmetry	Cytokinesis Response To Hypoxia Angiotensin-mediated Vasoconstriction Involved In Regulation Of Systemic Arterial Blood Pressure Alpha-beta T Cell Lineage Commitment Regulation Of Systemic Arterial Blood Pressure By Endothelin Regulation Of Transcription By RNA Polymerase II Actin Filament Organization Cell-matrix Adhesion Establishment Or Maintenance Of Cell Polarity Transforming Growth Factor Beta Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Rho Protein Signal Transduction Skeletal Muscle Tissue Development Regulation Of Cell Shape Response To Mechanical Stimulus Response To Glucose Negative Regulation Of Cell-substrate Adhesion Viral Process Cell Migration Protein Deubiquitination Substantia Nigra Development Cerebral Cortex Cell Migration Forebrain Radial Glial Cell Differentiation Actin Cytoskeleton Organization Positive Regulation Of Cell Growth Regulation Of Cell Migration Androgen Receptor Signaling Pathway Positive Regulation Of Actin Filament Polymerization Establishment Or Maintenance Of Actin Cytoskeleton Polarity Stress-activated Protein Kinase Signaling Cascade Actin Cytoskeleton Reorganization Positive Regulation Of Cytokinesis Regulation Of Actin Cytoskeleton Organization Negative Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Regulation Of Osteoblast Proliferation Cell Junction Assembly Roundabout Signaling Pathway Cleavage Furrow Formation Apolipoprotein A-I-mediated Signaling Pathway Odontogenesis Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Negative Regulation Of I-kappaB Kinase/NF-kappaB Signaling Stress Fiber Assembly Response To Amino Acid Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Apical Junction Assembly Neutrophil Degranulation Beta Selection Negative Regulation Of Neuron Apoptotic Process Positive Regulation Of Neuron Apoptotic Process Endothelial Cell Migration Ossification Involved In Bone Maturation Wound Healing, Spreading Of Cells Establishment Of Epithelial Cell Apical/basal Polarity Response To Ethanol Positive Regulation Of Neuron Differentiation Positive Regulation Of Translation Negative Regulation Of Cell Size GTP Metabolic Process Positive Regulation Of Alpha-beta T Cell Differentiation Vascular Endothelial Growth Factor Receptor Signaling Pathway Ephrin Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling Neuron Projection Morphogenesis Negative Regulation Of Axonogenesis Positive Regulation Of Axonogenesis Regulation Of Dendrite Development Negative Chemotaxis Actin Filament Bundle Assembly Regulation Of Small GTPase Mediated Signal Transduction Response To Glucocorticoid Positive Regulation Of Stress Fiber Assembly Regulation Of Focal Adhesion Assembly Regulation Of Calcium Ion Transport Wnt Signaling Pathway, Planar Cell Polarity Pathway Positive Regulation Of Lipase Activity Trabecula Morphogenesis Regulation Of Microtubule Cytoskeleton Organization Cellular Response To Lipopolysaccharide Cellular Response To Cytokine Stimulus Positive Regulation Of Podosome Assembly Positive Regulation Of Protein Serine/threonine Kinase Activity Negative Regulation Of Cell Migration Involved In Sprouting Angiogenesis Mitotic Spindle Assembly Negative Regulation Of Oxidative Phosphorylation Endothelial Tube Lumen Extension Positive Regulation Of NIK/NF-kappaB Signaling Skeletal Muscle Satellite Cell Migration Negative Regulation Of Reactive Oxygen Species Biosynthetic Process Mitotic Cleavage Furrow Formation Positive Regulation Of Vascular Smooth Muscle Contraction Positive Regulation Of Leukocyte Adhesion To Vascular Endothelial Cell Regulation Of Modification Of Postsynaptic Actin Cytoskeleton Cellular Response To Chemokine Regulation Of Cell Motility Regulation Of Neural Precursor Cell Proliferation Positive Regulation Of T Cell Migration
Pathways		Signaling by NODAL Signaling by NODAL Signaling by Activin Downregulation of TGF-beta receptor signaling TGF-beta receptor signaling activates SMADs Downregulation of SMAD2/3:SMAD4 transcriptional activity Downregulation of SMAD2/3:SMAD4 transcriptional activity SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription SMAD2/3 Phosphorylation Motif Mutants in Cancer SMAD4 MH2 Domain Mutants in Cancer SMAD2/3 MH2 Domain Mutants in Cancer TGFBR1 KD Mutants in Cancer Transcriptional regulation of pluripotent stem cells Ub-specific processing proteases FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes FOXO-mediated transcription of cell cycle genes FOXO-mediated transcription of cell cycle genes	GPVI-mediated activation cascade Axonal growth inhibition (RHOA activation) Rho GTPase cycle PI3K/AKT activation Axonal growth stimulation TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) G beta:gamma signalling through PI3Kgamma EPHB-mediated forward signaling EPHB-mediated forward signaling EPHA-mediated growth cone collapse EPHA-mediated growth cone collapse PCP/CE pathway G alpha (12/13) signalling events Sema4D mediated inhibition of cell attachment and migration Sema4D induced cell migration and growth-cone collapse Sema4D induced cell migration and growth-cone collapse VEGFA-VEGFR2 Pathway RHO GTPases activate PKNs RHO GTPases activate CIT RHO GTPases activate CIT RHO GTPases activate KTN1 RHO GTPases Activate ROCKs RHO GTPases Activate ROCKs RHO GTPases Activate Formins RHO GTPases Activate Rhotekin and Rhophilins RHO GTPases Activate Rhotekin and Rhophilins Ovarian tumor domain proteases ERBB2 Regulates Cell Motility Neutrophil degranulation PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases SLIT2:ROBO1 increases RHOA activity
Drugs		Dexfosfoserine	Guanosine-5'-Diphosphate
Diseases		Colorectal cancer
GWAS		Coronary artery disease in type 1 diabetes ( 29695241) Lung cancer in ever smokers ( 28604730) Menarche (age at onset) ( 27182965)	Blood protein levels ( 28240269) Cognitive function ( 25644384) Coronary artery disease ( 29212778 28714974) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975) Crohn's disease ( 28067908) Extremely high intelligence ( 29520040) General cognitive ability ( 29844566) Gut microbiota (functional units) ( 27694959) Household income (MTAG) ( 31844048) Inflammatory bowel disease ( 28067908) Mood instability ( 31168069) Morning person ( 30696823) Regular attendance at a religious group ( 29970889) Sleep duration (short sleep) ( 30846698) Ulcerative colitis ( 28067908)
Interacting Genes		209 interacting genes: ABTB1 ACVR1B AFDN AKT1 ANAPC10 ANAPC2 ANK3 ANP32B ANP32E ANTXR2 AP1B1 ARFGAP3 ARHGEF6 ARL4D ATP5ME AXIN1 BAZ1A BECN1 BPTF BRCA1 BTBD2 C22orf46 CAMK2A CAMK2G CDC16 CDC27 CDC40 CDK2 CDK4 CDK8 CDK9 CISH COPS5 CREBBP CSH1 CSH2 CSNK1D CTNNB1 CUL5 CYP11A1 DAB2 DCAF6 DCUN1D1 DENND2B DNAJC7 DOCK8 DVL1 DYNC1H1 E2F4 EEF1A1 EID2 EIF3L ELAC2 EP300 ERBIN ESR1 ESR2 FAM161B FBN2 FHL2 FHL3 FOXG1 FOXH1 FOXO3 GATAD2B GFER GLI3 GRIPAP1 GSC GTF2I HDAC1 HDAC2 HGS HIPK2 HNF4A HOXA13 HOXA9 HOXD13 HUWE1 HYAL2 INSR IRAK2 ITCH JUN KAT2B KHDRBS1 KPNB1 LAMA5 LATS2 LCK LEF1 LEMD3 LHX9 LITAF LMO2 MAPK1 MAPK3 MAPK8 MAPK9 MECOM MED15 MED6 MEF2A MEF2C MYC MYOCD NAGK NCOA6 NEDD4L NEDD9 NEFM NFIA NFYC NOTCH4 NUAK2 NUP153 NUP214 OS9 OTUB1 PAK1 PAPOLA PAPPA PARD3 PAXIP1 PEX19 PIAS3 PIAS4 PIK3CA PLIN3 POU2AF1 PPM1A PPP2R1A PRKAR1A PSAP PSG9 PSMD11 PSMD8 PTMS RAB34 RAB38 RAN RANBP6 RANBP9 RARB RASD2 RASL12 RBL1 RHEBL1 RHOA RHOD RHOJ RIT1 RNF123 RNPC3 ROCK1 RPS14 RPS27A RUNX2 RXRA SKI SKIL SKOR2 SMAD1 SMAD3 SMAD4 SMAD7 SMAD9 SMURF1 SMURF2 SNAPIN SNIP1 SNRNP70 SNW1 SOD1 SP1 SQSTM1 SRI ST13 STAG1 STAMBP STAMBPL1 STRAP STUB1 SYT1 TBC1D1 TGFBR1 TGFBRAP1 TGIF1 TGM2 TNNT1 TOB1 TP53 TP73 TRIM62 TSC2 TUBA1B UBA52 UBR5 UCHL5 USP9X WASHC4 YY1 ZEB1 ZEB2 ZFYVE9 ZMYND11 ZNF41 ZNF8 ZNHIT6	109 interacting genes: ACKR2 AGAP1 AGAP2 AKAP13 AMT ARF4 ARHGAP1 ARHGAP10 ARHGAP21 ARHGAP26 ARHGAP32 ARHGAP35 ARHGAP5 ARHGAP8 ARHGDIA ARHGDIB ARHGDIG ARHGEF1 ARHGEF11 ARHGEF12 ARHGEF18 ARHGEF2 ARHGEF25 ARHGEF28 ARHGEF3 ARHGEF4 ARIH2 ARNTL BCR BIRC2 C1QA CAMP CAV1 CIT CLOCK CNKSR1 CNTNAP1 DAAM1 DCUN1D1 DEF6 DGKQ DIAPH1 DIAPH3 DOCK7 DVL2 ENTPD3 FLNA FMN2 GMIP GPX1 HSPA1A ICMT IKBKG IKZF3 ITIH3 ITPR1 KCNA2 KCTD13 KLRG1 KTN1 LRP2 MCF2 MCF2L MPRIP NET1 NOTCH1 OPHN1 OTUB1 PDCD10 PDE6D PITPNM1 PKN1 PKN2 PLCG1 PLD1 PLEKHG2 PPP1R12A PRKACA PRKCA PRKCZ PTPRF RABAC1 RACK1 RAP1GDS1 RASGRF1 RASSF1 RHPN1 RHPN2 RIPK4 RIPOR2 ROCK1 RPN2 RTKN SH3BP1 SMAD2 SMURF1 SMURF2 SPRED2 SRGAP1 SUB1 TGFBR1 TGM2 TNFAIP1 TRIO TRIP6 TRPC1 VAV1 VAV2 VAV3
Entrez ID		4087	387
HPRD ID		03221	01323
Ensembl ID		ENSG00000175387	ENSG00000067560
Uniprot IDs		B7Z5N5 Q15796 Q53XR6	A0A024R324 B4DKN9 C9JRM1 C9JX21 P61586 Q9BVT0
PDB IDs		1DEV 1KHX 1U7V 2LB3 5XOD 5ZOJ 6H3R	1A2B 1CC0 1CXZ 1DPF 1FTN 1KMQ 1LB1 1OW3 1S1C 1TX4 1X86 1XCG 2RGN 3KZ1 3LW8 3LWN 3LXR 3MSX 3T06 4D0N 4XH9 4XOI 4XSG 4XSH 5A0F 5BWM 5C2K 5C4M 5EZ6 5FR1 5FR2 5HPY 5IRC 5JCP 5JHG 5JHH 5M6X 5M70 5ZHX 6BC0 6BCA 6BCB 6R3V
Enriched GO Terms of Interacting Partners?
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