LTF and ITLN1

Number of citations of the paper that reports this interaction (PubMedID 11313366)
73

Data Source:
HPRD (in vitro)

		LTF	ITLN1
Description		lactotransferrin	intelectin 1
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cell Nucleus Cytoplasm Cell Surface Secretory Granule Protein-containing Complex Specific Granule Lumen Specific Granule Extracellular Exosome Phagocytic Vesicle Lumen Tertiary Granule Lumen	Extracellular Region Anchored Component Of Membrane Brush Border Membrane Receptor Complex Membrane Raft Extracellular Exosome
	Molecular Function	Lipopolysaccharide Binding DNA Binding Serine-type Endopeptidase Activity Cysteine-type Endopeptidase Inhibitor Activity Iron Ion Binding Protein Binding Heparin Binding Protein Serine/threonine Kinase Activator Activity	Calcium Ion Binding Identical Protein Binding Oligosaccharide Binding
	Biological Process	Ossification Regulation Of Cytokine Production Retina Homeostasis Innate Immune Response In Mucosa Proteolysis Humoral Immune Response Antimicrobial Humoral Response Antibacterial Humoral Response Antifungal Humoral Response Killing Of Cells Of Other Organism Negative Regulation Of Lipopolysaccharide-mediated Signaling Pathway Regulation Of Tumor Necrosis Factor Production Negative Regulation Of ATPase Activity Iron Assimilation By Chelation And Transport Positive Regulation Of Osteoblast Proliferation Positive Regulation Of Toll-like Receptor 4 Signaling Pathway Negative Regulation Of Apoptotic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Neutrophil Degranulation Cellular Protein Metabolic Process Negative Regulation By Host Of Viral Process Negative Regulation Of Viral Genome Replication Positive Regulation Of Osteoblast Differentiation Negative Regulation Of Viral Process Defense Response To Gram-negative Bacterium Positive Regulation Of NF-kappaB Transcription Factor Activity Membrane Disruption In Other Organism Bone Morphogenesis Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Positive Regulation Of Protein Serine/threonine Kinase Activity Positive Regulation Of Bone Mineralization Involved In Bone Maturation Negative Regulation Of Single-species Biofilm Formation In Or On Host Organism Positive Regulation Of Chondrocyte Proliferation Negative Regulation Of Cysteine-type Endopeptidase Activity Negative Regulation Of Tumor Necrosis Factor (ligand) Superfamily Member 11 Production Negative Regulation Of Osteoclast Development	Positive Regulation Of Protein Phosphorylation Response To Nematode Antimicrobial Humoral Response Positive Regulation Of Glucose Import Protein Homotrimerization
Pathways		Mtb iron assimilation by chelation Neutrophil degranulation Metal sequestration by antimicrobial proteins Antimicrobial peptides Amyloid fiber formation	Antimicrobial peptides
Drugs		3h-Indole-5,6-Diol Lauric Acid Nitrilotriacetic Acid Alpha-D-Fucose Nimesulide 2-(4-(2-HYDROXY-3-(ISOPROPYLAMINO)PROPOXY)PHENYL)ETHANAMIDE Parecoxib
Diseases
GWAS		AIDS progression ( 21502085) Blood protein levels ( 30072576 29875488 28240269) Cerebrospinal fluid levels of Alzheimer's disease-related proteins ( 25340798) Inflammatory bowel disease ( 26192919) Macular thickness ( 30535121) Ulcerative colitis ( 26192919)	Blood protein levels ( 28240269) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Crohn's disease ( 18587394 28067908 21102463) Inflammatory bowel disease ( 28067908 23128233)
Interacting Genes		11 interacting genes: CALM1 CD14 CEL CP EPPIN ITLN1 LCN1 LRP1 LYZ MUC7 UBC	1 interacting genes: LTF
Entrez ID		4057	55600
HPRD ID		01028	17165
Ensembl ID		ENSG00000012223	ENSG00000179914
Uniprot IDs		B3KSL2 E7ER44 P02788 Q2TUW9 V9HWI4	Q8WWA0
PDB IDs		1B0L 1BKA 1CB6 1DSN 1EH3 1FCK 1H43 1H44 1H45 1HSE 1L5T 1LCF 1LCT 1LFG 1LFH 1LFI 1LGB 1N76 1SQY 1U62 1VFD 1VFE 1XV4 1XV7 1Z6V 1Z6W 2BJJ 2DP4 2GMC 2GMD 2HD4 2PMS	4WMQ 4WMY
Enriched GO Terms of Interacting Partners?
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