LTA and SLC30A2

Number of citations of the paper that reports this interaction (PubMedID 25910212)
127

Data Source:
BioGRID (two hybrid)

		LTA	SLC30A2
Description		lymphotoxin alpha	solute carrier family 30 member 2
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Space Plasma Membrane	Cytoplasm Lysosomal Membrane Late Endosome Plasma Membrane Membrane Integral Component Of Membrane Intracellular Membrane-bounded Organelle
	Molecular Function	Signaling Receptor Binding Cytokine Activity Tumor Necrosis Factor Receptor Binding	Zinc Ion Transmembrane Transporter Activity Protein Binding Identical Protein Binding
	Biological Process	Response To Hypoxia Positive Regulation Of Chronic Inflammatory Response To Antigenic Stimulus Positive Regulation Of Humoral Immune Response Mediated By Circulating Immunoglobulin Apoptotic Process Humoral Immune Response Signal Transduction Cell-cell Signaling Response To Nutrient Response To Lipopolysaccharide Positive Regulation Of Interferon-gamma Production Tumor Necrosis Factor-mediated Signaling Pathway Response To Drug Positive Regulation Of Apoptotic Process Negative Regulation Of Fibroblast Proliferation Lymph Node Development Defense Response To Gram-positive Bacterium Positive Regulation Of Glial Cell Proliferation	Response To Zinc Ion Regulation Of Sequestering Of Zinc Ion Positive Regulation Of Sequestering Of Zinc Ion Zinc Ion Transmembrane Transport
Pathways		TNFR2 non-canonical NF-kB pathway TNFs bind their physiological receptors TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway	Zinc efflux and compartmentalization by the SLC30 family
Drugs		Etanercept
Diseases
GWAS		Asthma ( 31619474) Asthma (childhood onset) ( 31619474) Asthma and major depressive disorder ( 31619474) Autism spectrum disorder or schizophrenia ( 28540026) Blood protein levels ( 28240269) Crohn's disease ( 21102463) Inflammatory bowel disease ( 28067908) Lymphocyte counts ( 27863252) Lymphocyte percentage of white cells ( 27863252) Neonatal lupus ( 20662065) Sarcoidosis (non-Lofgren's syndrome without extrapulmonary manifestations) ( 26651848) Type 1 diabetes and autoimmune thyroid diseases ( 25936594) Ulcerative colitis ( 28067908) White blood cell count ( 27863252)
Interacting Genes		10 interacting genes: CREB3 LGALS2 LTB LTBR SLC30A2 TNFRSF14 TNFRSF1A TNFRSF1B TUBA4A UMOD	11 interacting genes: ADAM33 CCL4 CCL4L2 CD99L2 CREB3 KASH5 LMNA LTA PVR SERPING1 TNFRSF12A
Entrez ID		4049	7780
HPRD ID		01084	18057
Ensembl ID		ENSG00000226979	ENSG00000158014
Uniprot IDs		P01374 Q5STV3	Q9BRI3
PDB IDs		1TNR 4MXV 4MXW
Enriched GO Terms of Interacting Partners?
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