ARL2 and PDE6D

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid, two hybrid, two hybrid, x-ray crystallography)
HPRD (in vitro)

		ARL2	PDE6D
Description		ADP ribosylation factor like GTPase 2	phosphodiesterase 6D
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytoplasm Mitochondrial Intermembrane Space Mitochondrial Matrix Golgi Apparatus Centrosome Cytosol Focal Adhesion Cilium Microtubule Cytoskeleton Lateral Plasma Membrane	Cytosol Cytoskeleton Cilium Cytoplasmic Vesicle Membrane Cytoplasmic Vesicle
	Molecular Function	GTPase Activity GTPase Inhibitor Activity Protein Binding GTP Binding GDP Binding	3',5'-cyclic-nucleotide Phosphodiesterase Activity GTPase Inhibitor Activity Protein Binding Rab GTPase Binding
	Biological Process	Tubulin Complex Assembly Centrosome Cycle Positive Regulation Of Cell-substrate Adhesion Regulation Of Microtubule Polymerization Positive Regulation Of Microtubule Polymerization Negative Regulation Of GTPase Activity Regulation Of Insulin Secretion Maintenance Of Protein Location In Nucleus Bicellular Tight Junction Assembly	Visual Perception Negative Regulation Of GTPase Activity Response To Stimulus
Pathways		Post-chaperonin tubulin folding pathway Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane	ARL13B-mediated ciliary trafficking of INPP5E
Drugs
Diseases
GWAS			Eating disorders (purging via substances) ( 23568457) Height ( 18391951)
Interacting Genes		6 interacting genes: ARL2BP PDE6D POLA2 TBCD TBL1XR1 UNC119	24 interacting genes: ARL15 ARL16 ARL2 ARL3 CDC42 CETN3 FAM219A GNAI1 GRK1 GRK7 HRAS PTGIR RAB13 RAB18 RAB8A RAD23A RAP1A RAP2B RASA1 RHEB RHOA RHOB RND1 RPGR
Entrez ID		402	5147
HPRD ID		11869	04056
Ensembl ID		ENSG00000213465	ENSG00000156973
Uniprot IDs		P36404 Q53YD8	B8ZZK5 O43924 Q6IB24
PDB IDs		3DOE 3DOF	1KSG 1KSH 1KSJ 3T5G 3T5I 4JHP 4JV6 4JV8 4JVB 4JVF 5E80 5E8F 5F2U 5ML2 5ML3 5ML4 5ML6 5ML8 5NAL 5TAR 5TB5 5X72 5X73 5X74 5YAV 5YAW
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?