LIFR and CNTF

Number of citations of the paper that reports this interaction (PubMedID 12643274)
21

Data Source:
HPRD (in vitro)

		LIFR	CNTF
Description		LIF receptor subunit alpha	ciliary neurotrophic factor
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GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane Receptor Complex Extracellular Exosome	Extracellular Region Extracellular Space Cytoplasm Axon
	Molecular Function	Cytokine Receptor Activity Ciliary Neurotrophic Factor Receptor Activity Leukemia Inhibitory Factor Receptor Activity Oncostatin-M Receptor Activity Ciliary Neurotrophic Factor Receptor Binding Protein Binding Growth Factor Binding Cytokine Binding	Cytokine Activity Ciliary Neurotrophic Factor Receptor Binding Interleukin-6 Receptor Binding Protein Binding Growth Factor Activity Protein-containing Complex Binding
	Biological Process	Regulation Of Cytokine-mediated Signaling Pathway Cell Surface Receptor Signaling Pathway Positive Regulation Of Cell Proliferation Cytokine-mediated Signaling Pathway Response To Cytokine Oncostatin-M-mediated Signaling Pathway Leukemia Inhibitory Factor Signaling Pathway Ciliary Neurotrophic Factor-mediated Signaling Pathway	Signal Transduction Positive Regulation Of Cell Proliferation Positive Regulation Of Gene Expression Cytokine-mediated Signaling Pathway Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Negative Regulation Of Neuron Apoptotic Process Negative Regulation Of Photoreceptor Cell Differentiation Regulation Of Retinal Cell Programmed Cell Death Astrocyte Activation Muscle Organ Morphogenesis Neuron Development Positive Regulation Of Axon Regeneration Ciliary Neurotrophic Factor-mediated Signaling Pathway
Pathways		IL-6-type cytokine receptor ligand interactions RUNX1 regulates transcription of genes involved in interleukin signaling	IL-6-type cytokine receptor ligand interactions
Drugs
Diseases		Stuve-Wiedemann syndrome
GWAS		Blood protein levels ( 30072576) Crohn's disease ( 26192919) Inflammatory bowel disease ( 26192919) Pursuit maintenance gain ( 29064472) Ulcerative colitis ( 26192919)	Diastolic blood pressure ( 27841878) Inflammatory bowel disease ( 23128233) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Pulse pressure ( 27841878) Systolic blood pressure ( 27841878) Ulcerative colitis ( 28067908)
Interacting Genes		12 interacting genes: CNTF CNTFR CTF1 IL31RA IL6ST LIF MAPK1 OSM PLCG1 POU2F1 PTPN11 PTPN6	8 interacting genes: APOE CNTFR IL6R IL6ST KRT40 LIFR TIMM10 TRIP6
Entrez ID		3977	1270
HPRD ID		01048	00347
Ensembl ID		ENSG00000113594	ENSG00000242689
Uniprot IDs		A8K1Z4 P42702	P26441
PDB IDs		3E0G	1CNT
Enriched GO Terms of Interacting Partners?
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