LAMA3 and PLAT

Number of citations of the paper that reports this interaction (PubMedID 10956663)
8

Data Source:
BioGRID (pull down)
HPRD (in vitro)

		LAMA3	PLAT
Description		laminin subunit alpha 3	plasminogen activator, tissue type
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Basement Membrane Laminin-5 Complex Endoplasmic Reticulum Collagen-containing Extracellular Matrix Extracellular Exosome	Extracellular Region Extracellular Space Cytoplasm Cell Surface Secretory Granule Apical Part Of Cell Collagen-containing Extracellular Matrix Extracellular Exosome Schaffer Collateral - CA1 Synapse Glutamatergic Synapse
	Molecular Function	Integrin Binding Structural Molecule Activity Extracellular Matrix Structural Constituent	Serine-type Endopeptidase Activity Signaling Receptor Binding Protein Binding Phosphoprotein Binding
	Biological Process	Morphogenesis Of A Polarized Epithelium Integrin-mediated Signaling Pathway Epidermis Development Animal Organ Morphogenesis Tissue Development Cell Migration Regulation Of Cell Adhesion Extracellular Matrix Organization Regulation Of Cell Migration Hemidesmosome Assembly Endodermal Cell Differentiation Regulation Of Embryonic Development Cell-cell Adhesion	Response To Hypoxia Cellular Protein Modification Process Proteolysis Blood Coagulation Smooth Muscle Cell Migration Plasminogen Activation Fibrinolysis Negative Regulation Of Proteolysis Platelet-derived Growth Factor Receptor Signaling Pathway Trans-synaptic Signaling By BDNF, Modulating Synaptic Transmission
Pathways		Degradation of the extracellular matrix Degradation of the extracellular matrix Assembly of collagen fibrils and other multimeric structures Anchoring fibril formation Laminin interactions Laminin interactions Non-integrin membrane-ECM interactions ECM proteoglycans Type I hemidesmosome assembly MET activates PTK2 signaling	Signaling by PDGF Dissolution of Fibrin Clot
Drugs			Urokinase Aminocaproic Acid Ibuprofen Iloprost Human C1-esterase inhibitor 5-(DIMETHYLAMINO)-2-NAPHTHALENESULFONIC ACID Dexibuprofen Conestat alfa
Diseases		Laryngoonychocutaneous syndrome Epidermolysis bullosa, junctional, including: Epidermolysis bullosa, junctional, Herlitz type (JEB-H); Epidermolysis bullosa, junctional, non-Herlitz type (JEB-nH); Epidermolysis bullosa, junctional, with pyloric atresia (JEB-PA) Epidermolysis bullosa, hemidesmosomal, including: Epidermolysis bullosa, generalized atrophic benign (GABEB); Epidermolysis bullosa simplex with pyloric atresia (EBS-PA); Epidermolysis bullosa simplex with muscular dystrophy (EBS-MD); Epidermolysis bullosa simplex, Ogna type (EBS-Ogna)
GWAS		Allergic rhinitis ( 25085501) Amyotrophic lateral sclerosis ( 22959728) Composite immunoglobulin trait (IgA x IgG/IgM) ( 28628107) High light scatter reticulocyte count ( 27863252) High light scatter reticulocyte percentage of red cells ( 27863252)	Blood protein levels ( 30072576) Plasma plasminogen activator levels ( 24578379) Systemic lupus erythematosus ( 28714469)
Interacting Genes		7 interacting genes: APC BMP1 LAMB3 PLAT PLG SDC2 SLC35E1	36 interacting genes: ANXA2 APP BAG4 CALR CKAP4 CLEC3B CRABP1 CRTC1 DDHD2 EIF4EBP1 F10 FGA FN1 GML GRIN1 HMGB1 KRT8 LAMA1 LAMA3 LRP1 LRP1B MAPK1 MAPK3 MTDH PDGFC PLAU PLG PPP2CB PVR SART1 SERPINA5 SERPINE1 SERPING1 SERPINI1 SLC28A2 SPARC
Entrez ID		3909	5327
HPRD ID		02883	01419
Ensembl ID		ENSG00000053747	ENSG00000104368
Uniprot IDs		A0A0A0MSA0 A0A0A0MTS5 A0A0A6YYF2 Q16787	B4DN26 P00750
PDB IDs			1A5H 1BDA 1PK2 1PML 1RTF 1TPG 1TPK 1TPM 1TPN 5BRR 5ZLZ
Enriched GO Terms of Interacting Partners?
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