KRT14 and TRADD

Number of citations of the paper that reports this interaction (PubMedID 11684708)
52

Data Source:
HPRD (in vitro)

		KRT14	TRADD
Description		keratin 14	TNFRSF1A associated via death domain
Image
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Intermediate Filament Keratin Filament Basal Part Of Cell Extracellular Exosome Cell Periphery	Tumor Necrosis Factor Receptor Superfamily Complex Nucleus Cytoplasm Cytosol Cytoskeleton Plasma Membrane Death-inducing Signaling Complex Receptor Complex Membrane Raft
	Molecular Function	Structural Constituent Of Cytoskeleton Protein Binding Keratin Filament Binding	Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity Tumor Necrosis Factor Receptor Binding Protein Binding Kinase Binding Identical Protein Binding Protein-containing Complex Binding Death Domain Binding
	Biological Process	Aging Epidermis Development Response To Zinc Ion Response To Ionizing Radiation Keratinization Hemidesmosome Assembly Hair Cycle Intermediate Filament Bundle Assembly Cornification	Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway I-kappaB Kinase/NF-kappaB Signaling Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Cell Migration Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Apoptotic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Inflammatory Response Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Hair Follicle Development Cellular Response To Tumor Necrosis Factor Death-inducing Signaling Complex Assembly Extrinsic Apoptotic Signaling Pathway Positive Regulation Of NIK/NF-kappaB Signaling Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors
Pathways		Type I hemidesmosome assembly Keratinization Formation of the cornified envelope	Caspase activation via Death Receptors in the presence of ligand Regulation by c-FLIP RIPK1-mediated regulated necrosis CASP8 activity is inhibited TNFR1-induced proapoptotic signaling Regulation of TNFR1 signaling TNFR1-induced NFkappaB signaling pathway Regulation of necroptotic cell death Dimerization of procaspase-8 TNF signaling
Drugs		Zinc
Diseases		Naegeli-Franceschetti-Jadassohn syndrome Dermatopathia pigmentosa reticularis Epidermolysis bullosa simplex, including: Epidermolysis bullosa simplex, Dowling-Meara type (EBS-DM); Epidermolysis bullosa simplex, Koebner type (EBS-K); Epidermolysis bullosa simplex, Weber-Cockayne type (EBS-WC); Epidermolysis bullosa simplex with mottled pigmentation (EBS-MP); Epidermolysis bullosa simplex with migratory circinate erythema; Epidermolysis bullosa simplex, recessive; Epidermolysis bullosa, lethal acantholytic
GWAS
Interacting Genes		7 interacting genes: APC DST HSPA5 KRT5 PKP1 TCHP TRADD	23 interacting genes: APBB2 BCL10 BIRC2 CNTRL DAPK1 FADD FAS HIPK2 KRT14 KRT18 NGFR PPP2R1A RIPK1 STAT1 TNFRSF10A TNFRSF10B TNFRSF1A TNFRSF21 TNFRSF25 TRAF1 TRAF2 TRAF3 TRPC4AP
Entrez ID		3861	8717
HPRD ID		01017	04610
Ensembl ID		ENSG00000186847	ENSG00000102871
Uniprot IDs		P02533	Q15628
PDB IDs		3TNU	1F2H 1F3V 5XME 6AC0
Enriched GO Terms of Interacting Partners?
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