KLK2 and SEMG1

Number of citations of the paper that reports this interaction (PubMedID 10411640)
9

Data Source:
HPRD (in vitro)

		KLK2	SEMG1
Description		kallikrein related peptidase 2	semenogelin 1
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Secretory Granule Extracellular Exosome	Extracellular Region Extracellular Space Nucleus Protein-containing Complex Extracellular Exosome
	Molecular Function	Serine-type Endopeptidase Activity	Protein Binding Zinc Ion Binding
	Biological Process	Regulation Of Systemic Arterial Blood Pressure Extracellular Matrix Disassembly Zymogen Activation	Insemination Antimicrobial Humoral Response Antibacterial Humoral Response Killing Of Cells Of Other Organism Cellular Protein Metabolic Process Sperm Capacitation Coagulation Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Negative Regulation Of Calcium Ion Import Positive Regulation Of Serine-type Endopeptidase Activity Negative Regulation Of Flagellated Sperm Motility
Pathways		Activation of Matrix Metalloproteinases Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3	Antimicrobial peptides Amyloid fiber formation
Drugs			Zinc
Diseases
GWAS		Celiac disease ( 23936387) PCA3 expression level ( 23555189) Prostate cancer ( 31562322) Prostate-specific antigen levels ( 23359319 28139693) Prostate-specific antigen levels (conditioned on lead SNPs) ( 28139693) Tandem gait ( 26219847)	Bipolar disorder ( 31043756) Blood protein levels ( 28240269)
Interacting Genes		14 interacting genes: A2M APP AR IGFBP2 POLR2A SEMG1 SEMG2 SERPINA3 SERPINA4 SERPINA5 SERPINB6 SERPINC1 SERPINE1 SERPINF2	7 interacting genes: KLK2 KLK3 PRKCA PTPRF SEMG2 TGM1 UBQLN4
Entrez ID		3817	6406
HPRD ID		01006	01641
Ensembl ID		ENSG00000167751	ENSG00000124233
Uniprot IDs		A0A024R4J4 A0A024R4N3 B4DU77 P20151	P04279
PDB IDs		4NFE 4NFF
Enriched GO Terms of Interacting Partners?
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