NHLRC1 and PPP1R3C

Number of citations of the paper that reports this interaction (PubMedID 18070875)
62

Data Source:
BioGRID (enzymatic study, two hybrid)

		NHLRC1	PPP1R3C
Description		NHL repeat containing E3 ubiquitin protein ligase 1	protein phosphatase 1 regulatory subunit 3C
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Endoplasmic Reticulum Cytosol Perinuclear Region Of Cytoplasm	Cytosol
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Metal Ion Binding Ubiquitin Protein Ligase Activity	Protein Serine/threonine Phosphatase Activity Protein Binding Protein Phosphatase Binding Glycogen Binding
	Biological Process	Protein Polyubiquitination Glycogen Biosynthetic Process Autophagy Regulation Of Gene Expression Positive Regulation Of Protein Ubiquitination Response To Endoplasmic Reticulum Stress Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Kinase Activity Regulation Of Protein Localization To Plasma Membrane	Glycogen Metabolic Process Glycogen Biosynthetic Process Protein Dephosphorylation
Pathways		Glycogen synthesis Myoclonic epilepsy of Lafora	Glycogen synthesis Myoclonic epilepsy of Lafora
Drugs
Diseases		Progressive myoclonic epilepsy (PME), including: Lafora disease (LBD); Unverricht-Lundborg disease (ULD); Neuronal ceroid lipofuscinoses (NCL); Type I sialidosis; Action myoclonus-renal failure syndrome (AMRF); Type III Gaucher disease (GD)
GWAS		Intrinsic epigenetic age acceleration ( 29374233)
Interacting Genes		9 interacting genes: AGL EPM2A GYS1 NNAT PPP1R3C UBE2D1 UBE2D3 UBE2E1 UBE2H	5 interacting genes: APP EPM2A ERGIC1 NHLRC1 SGTA
Entrez ID		378884	5507
HPRD ID		06995	04298
Ensembl ID		ENSG00000187566	ENSG00000119938
Uniprot IDs		Q6VVB1	Q9UQK1
PDB IDs
Enriched GO Terms of Interacting Partners?
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