KCNJ9 and DRD4

Number of citations of the paper that reports this interaction (PubMedID 12297500)
45

Data Source:
HPRD (in vitro, in vivo)

		KCNJ9	DRD4
Description		potassium inwardly rectifying channel subfamily J member 9	dopamine receptor D4
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Parallel Fiber To Purkinje Cell Synapse Integral Component Of Presynaptic Membrane	Cell Plasma Membrane Integral Component Of Plasma Membrane Membrane Dendrite Postsynapse Glutamatergic Synapse
	Molecular Function	Inward Rectifier Potassium Channel Activity Protein Binding G-protein Activated Inward Rectifier Potassium Channel Activity	Dopamine Neurotransmitter Receptor Activity, Coupled Via Gi/Go G Protein-coupled Receptor Activity Dopamine Neurotransmitter Receptor Activity G Protein-coupled Serotonin Receptor Activity Protein Binding Drug Binding Potassium Channel Regulator Activity SH3 Domain Binding Neurotransmitter Receptor Activity Dopamine Binding Identical Protein Binding Metal Ion Binding Epinephrine Binding Norepinephrine Binding
	Biological Process	Regulation Of Ion Transmembrane Transport Potassium Ion Import Across Plasma Membrane	Activation Of MAPK Activity Behavioral Fear Response Synaptic Transmission, Dopaminergic Response To Amphetamine Cellular Calcium Ion Homeostasis G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-inhibiting Dopamine Receptor Signaling Pathway Dopamine Receptor Signaling Pathway Chemical Synaptic Transmission Adult Locomotory Behavior Positive Regulation Of Sodium:proton Antiporter Activity Positive Regulation Of Kinase Activity Response To Histamine Social Behavior Regulation Of Dopamine Metabolic Process Dopamine Metabolic Process Fear Response Regulation Of Circadian Rhythm Behavioral Response To Cocaine Behavioral Response To Ethanol Rhythmic Process Arachidonic Acid Secretion Negative Regulation Of Protein Secretion Positive Regulation Of Dopamine Uptake Involved In Synaptic Transmission Inhibitory Postsynaptic Potential G Protein-coupled Serotonin Receptor Signaling Pathway Regulation Of Postsynaptic Neurotransmitter Receptor Internalization Negative Regulation Of Voltage-gated Calcium Channel Activity
Pathways		Activation of G protein gated Potassium channels Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits	Dopamine receptors G alpha (i) signalling events
Drugs		Ethanol	Ziprasidone Cabergoline Ropinirole Olanzapine Clozapine Thiethylperazine Loxapine Remoxipride Pramipexole Promazine Chlorpromazine Amoxapine Lisuride Apomorphine Risperidone Propiomazine Dopamine Pergolide Bromocriptine Quetiapine Levodopa Aripiprazole Paliperidone Methotrimeprazine Flibanserin Iloperidone Rotigotine Asenapine Perospirone Pardoprunox
Diseases
GWAS		Alcohol consumption over the past year ( 29058377)
Interacting Genes		6 interacting genes: ADRB2 ATP6V1A DRD2 DRD4 KCNJ3 KCNJ6	6 interacting genes: CLIC6 GABRA1 GRB2 KCNJ9 KLHL12 NCK1
Entrez ID		3765	1815
HPRD ID		02959	00541
Ensembl ID		ENSG00000162728	ENSG00000069696
Uniprot IDs		Q92806	P21917
PDB IDs			5WIU 5WIV
Enriched GO Terms of Interacting Partners?
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