KCNE1 and UBASH3A

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid)

		KCNE1	UBASH3A
Description		potassium voltage-gated channel subfamily E regulatory subunit 1	ubiquitin associated and SH3 domain containing A
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GO Annotations	Cellular Component	Lysosome Plasma Membrane Voltage-gated Potassium Channel Complex Cell Surface Apical Plasma Membrane Z Disc Membrane Raft	Nucleoplasm Cytoplasm Golgi Apparatus Cytosol Extracellular Exosome
	Molecular Function	Voltage-gated Potassium Channel Activity Delayed Rectifier Potassium Channel Activity Protein Binding Potassium Channel Regulator Activity Telethonin Binding Ion Channel Binding Voltage-gated Potassium Channel Activity Involved In Cardiac Muscle Cell Action Potential Repolarization Voltage-gated Potassium Channel Activity Involved In Ventricular Cardiac Muscle Cell Action Potential Repolarization	Protein Binding
	Biological Process	Sensory Perception Of Sound Regulation Of Ventricular Cardiac Muscle Cell Membrane Repolarization Cardiac Conduction Cellular Response To CAMP Potassium Ion Transmembrane Transport Cardiac Muscle Cell Action Potential Involved In Contraction Ventricular Cardiac Muscle Cell Action Potential Membrane Repolarization Membrane Repolarization During Action Potential Membrane Repolarization During Cardiac Muscle Cell Action Potential Regulation Of Heart Rate By Cardiac Conduction Negative Regulation Of Protein Targeting To Membrane Potassium Ion Export Across Plasma Membrane Membrane Repolarization During Ventricular Cardiac Muscle Cell Action Potential Regulation Of Potassium Ion Transmembrane Transport Positive Regulation Of Potassium Ion Transmembrane Transport Regulation Of Delayed Rectifier Potassium Channel Activity Negative Regulation Of Delayed Rectifier Potassium Channel Activity	Regulation Of Cytokine Production Negative Regulation Of T Cell Receptor Signaling Pathway
Pathways		Phase 3 - rapid repolarisation Phase 2 - plateau phase
Drugs		Indapamide Azimilide
Diseases		Long QT syndrome, including: Romano-Ward syndrome; Jervell and Lange-Nielsen syndrome (JLNS)
GWAS		Electrocardiographic traits ( 20062063) Hippocampal volume ( 29274321) QT interval ( 30679814 29213071 24952745 31217584)	Celiac disease ( 22057235) Celiac disease and Rheumatoid arthritis ( 26546613) Celiac disease or Rheumatoid arthritis ( 21383967) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Diverticular disease ( 30177863) Medication use (thyroid preparations) ( 31015401) Primary sclerosing cholangitis ( 27992413) Rheumatoid arthritis ( 30423114 24390342 20453842) Rheumatoid arthritis (ACPA-positive) ( 24532676) Type 1 diabetes ( 21829393 25751624 19430480 18840781) Vitiligo ( 20410501 27723757)
Interacting Genes		6 interacting genes: ADRB2 KCNH2 KCNQ1 PRKCA TPM3 UBASH3A	17 interacting genes: CBL CBS DAZAP2 IKBKG KCNE1 KRT40 MAP3K7 PRKN REL RNF41 SF3B4 SPRY2 TP53BP2 TRIM37 UBB UBC UBE2L3
Entrez ID		3753	53347
HPRD ID		01442	06904
Ensembl ID		ENSG00000180509	ENSG00000160185
Uniprot IDs		A7LFK2 A7LFK4 C7S316 P15382 Q6FHJ6	P57075
PDB IDs		2K21	2CRN 5WDI
Enriched GO Terms of Interacting Partners?
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