ITPR3 and TRPC7

Number of citations of the paper that reports this interaction (PubMedID 11290752)
72

Data Source:
BioGRID (pull down)

		ITPR3	TRPC7
Description		inositol 1,4,5-trisphosphate receptor type 3	transient receptor potential cation channel subfamily C member 7
Image			No pdb structure
GO Annotations	Cellular Component	Cell Nuclear Outer Membrane Nucleoplasm Nucleolus Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Integral Component Of Plasma Membrane Brush Border Membrane Sarcoplasmic Reticulum Cytoplasmic Vesicle Membrane Secretory Granule Membrane Platelet Dense Tubular Network Membrane Neuronal Cell Body Myelin Sheath Receptor Complex Apical Part Of Cell	Cell Nuclear Envelope Cis-Golgi Network Plasma Membrane Integral Component Of Plasma Membrane Cation Channel Complex Perinuclear Region Of Cytoplasm
	Molecular Function	Inositol Hexakisphosphate Binding Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity Calcium Ion Binding Protein Binding Calcium-release Channel Activity Phosphatidylinositol Binding Inositol 1,3,4,5 Tetrakisphosphate Binding Inositol 1,4,5 Trisphosphate Binding	Protein Binding Store-operated Calcium Channel Activity Inositol 1,4,5 Trisphosphate Binding
	Biological Process	G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Memory Platelet Activation Inositol Phosphate-mediated Signaling Regulation Of Insulin Secretion Sensory Perception Of Bitter Taste Sensory Perception Of Sweet Taste Sensory Perception Of Umami Taste Release Of Sequestered Calcium Ion Into Cytosol Response To Calcium Ion Long-term Synaptic Potentiation Calcium Ion Transport Into Cytosol Regulation Of Cardiac Conduction	Manganese Ion Transport Single Fertilization Platelet Activation Regulation Of Cytosolic Calcium Ion Concentration Calcium Ion Transmembrane Transport
Pathways		PLC beta mediated events Effects of PIP2 hydrolysis Elevation of cytosolic Ca2+ levels DAG and IP3 signaling Role of phospholipids in phagocytosis FCERI mediated Ca+2 mobilization Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Ca2+ pathway Regulation of insulin secretion VEGFR2 mediated cell proliferation Ion homeostasis Ion homeostasis CLEC7A (Dectin-1) induces NFAT activation FCGR3A-mediated IL10 synthesis Antigen activates B Cell Receptor (BCR) leading to generation of second messengers Antigen activates B Cell Receptor (BCR) leading to generation of second messengers	Effects of PIP2 hydrolysis Elevation of cytosolic Ca2+ levels TRP channels Role of second messengers in netrin-1 signaling
Drugs		Caffeine
Diseases		Type I diabetes mellitus
GWAS		Allergic disease (asthma, hay fever or eczema) ( 29083406) Asthma and attention deficit hyperactivity disorder ( 31619474) Body mass index ( 26426971) Chronic obstructive pulmonary disease or resting heart rate (pleiotropy) ( 30940143) Crohn's disease ( 23850713) Educational attainment ( 23722424) Hodgkin's lymphoma ( 30194254) Multiple sclerosis and body mass index (pleiotropy) ( 26920376) Obesity (extreme) ( 19553259) Phosphorus levels ( 20558539) Regular attendance at a gym or sports club ( 29970889) Venous thromboembolism adjusted for sickle cell variant rs77121243-T ( 28203683)	Body fat percentage ( 31752434) Docetaxel-induced peripheral neuropathy in metastatic castrate-resistant prostate cancer ( 27143689) Sleep duration (short sleep) ( 30846698)
Interacting Genes		18 interacting genes: AKT1 ANK1 BAP1 CABP1 FBXL2 ITPR1 MTDH MTNR1A MTNR1B SIGMAR1 TRPC1 TRPC2 TRPC3 TRPC4 TRPC5 TRPC6 TRPC7 TRPM2	4 interacting genes: ITPR3 MX1 TRPC3 TRPC6
Entrez ID		3710	57113
HPRD ID		00926	18228
Ensembl ID		ENSG00000096433	ENSG00000069018
Uniprot IDs		A6H8K3 Q14573 Q59ES2	Q9HCX4
PDB IDs		6DQJ 6DQN 6DQS 6DQV 6DQZ 6DR0 6DR2 6DRA 6DRC
Enriched GO Terms of Interacting Partners?
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