INSM1 and CCND1

Number of citations of the paper that reports this interaction (PubMedID 16569215)
24

Data Source:
HPRD (in vivo, two hybrid, in vitro)

		INSM1	CCND1
Description		INSM transcriptional repressor 1	cyclin D1
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Transcriptional Repressor Complex	Cyclin-dependent Protein Kinase Holoenzyme Complex Intracellular Nucleus Nucleoplasm Cytoplasm Cytosol Bicellular Tight Junction Transcriptional Repressor Complex Nuclear Membrane
	Molecular Function	RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Cyclin Binding Chromatin DNA Binding Histone Deacetylase Binding Metal Ion Binding	Transcription Corepressor Activity Protein Kinase Activity Protein Binding Transcription Factor Binding Cyclin-dependent Protein Serine/threonine Kinase Regulator Activity Enzyme Binding Protein Kinase Binding Histone Deacetylase Binding Protein-containing Complex Binding Proline-rich Region Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Protein Phosphorylation Type B Pancreatic Cell Differentiation Pancreatic A Cell Differentiation Type B Pancreatic Cell Development Noradrenergic Neuron Development Cell Cycle Negative Regulation Of Cell Proliferation Regulation Of Gene Expression Regulation Of Cell Cycle Process Neuron Differentiation Positive Regulation Of Cell Migration Endocrine Pancreas Development Norepinephrine Biosynthetic Process Regulation Of Protein Complex Assembly Positive Regulation Of Cell Differentiation Transdifferentiation Adrenal Chromaffin Cell Differentiation Sympathetic Ganglion Development Positive Regulation Of Cell Cycle Arrest Positive Regulation Of Neural Precursor Cell Proliferation	Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Transcription By RNA Polymerase II Re-entry Into Mitotic Cell Cycle Positive Regulation Of Protein Phosphorylation Transcription Initiation From RNA Polymerase II Promoter Protein Phosphorylation Cellular Response To DNA Damage Stimulus Lactation Response To Iron Ion Response To X-ray Response To Organonitrogen Compound Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Wnt Signaling Pathway Cytokine-mediated Signaling Pathway Negative Regulation Of Epithelial Cell Differentiation Endoplasmic Reticulum Unfolded Protein Response Mitotic G1 DNA Damage Checkpoint Response To Magnesium Ion Response To Estradiol Response To Vitamin E Leydig Cell Differentiation Mammary Gland Epithelial Cell Proliferation Positive Regulation Of Mammary Gland Epithelial Cell Proliferation Response To Drug Response To Estrogen Response To Leptin Mitotic Cell Cycle Phase Transition Fat Cell Differentiation Response To Ethanol Positive Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Positive Regulation Of Cell Cycle Cell Division Response To Corticosterone Response To Calcium Ion Mammary Gland Alveolus Development Response To UV-A Negative Regulation Of Cell Cycle Arrest Liver Regeneration Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle
Pathways		Regulation of gene expression in endocrine-committed (NEUROG3+) progenitor cells	SCF(Skp2)-mediated degradation of p27/p21 Pre-NOTCH Transcription and Translation RMTs methylate histone arginines Interleukin-4 and Interleukin-13 signaling Cyclin D associated events in G1 Ubiquitin-dependent degradation of Cyclin D Ubiquitin-dependent degradation of Cyclin D PTK6 Regulates Cell Cycle Transcriptional Regulation by VENTX Transcriptional regulation by RUNX2 Regulation of RUNX1 Expression and Activity RUNX3 regulates WNT signaling RUNX3 regulates p14-ARF Estrogen-dependent gene expression Estrogen-dependent nuclear events downstream of ESR-membrane signaling
Drugs			Arsenic trioxide
Diseases			Hairy-cell leukemia von Hippel-Lindau syndrome Esophageal cancer Oral cancer Multiple myeloma Laryngeal cancer Breast cancer
GWAS			Birth weight ( 31043758) Blond vs. brown/black hair color ( 30531825) Body fat distribution (arm fat ratio) ( 30664634) Breast cancer ( 29059683 20453838) Breast cancer (early onset) ( 24493630) Breast size ( 22747683 27182965) Craniofacial microsomia ( 26853712) Cutaneous malignant melanoma ( 26237428) Diastolic blood pressure ( 27841878) Height ( 25429064) Hip circumference ( 25673412) Idiopathic dilated cardiomyopathy ( 29495422) Immunoglobulin light chain (AL) amyloidosis ( 28025584) Melanoma ( 28212542) Multiple myeloma (IgH translocation) ( 23502783) Nevus count or cutaneous melanoma ( 30429480) Offspring birth weight ( 31043758) Total body bone mineral density ( 29304378) Type 2 diabetes ( 30297969 30718926)
Interacting Genes		5 interacting genes: CCND1 KDM1A MPP3 SORBS1 TUBB3	70 interacting genes: AKAP8 AR ARID4A ATF2 BCAS3 BRCA1 BRCA2 BRINP1 BTRC CALM1 CAMK1 CCNDBP1 CDH13 CDK4 CDK6 CDKN1A CDKN1B CRYAB CTNNB1 CUL2 CUL3 DMTF1 EP300 ESR1 FBXO31 FBXO4 FOS GSK3B HDAC3 HERC5 IFI27 INSM1 JUN JUND KAT2B KLK7 KLK9 LPL MAPK11 MCM10 MCM7 MYBL2 NCOA1 NCOA3 NPDC1 ORC4 PCNA POLR1B PRKACA PRKN RABEP1 RAD51 RANBP9 RB1 RBL1 RBL2 RBX1 RFC1 RUNX1 SP1 STAT3 TAF1 THRA THRB TP73 TSC2 UBTF UHRF2 USP2 XPO1
Entrez ID		3642	595
HPRD ID		02480	01346
Ensembl ID		ENSG00000173404	ENSG00000110092
Uniprot IDs		Q01101	P24385 Q6FI00
PDB IDs		2LV2 3ZMS	2W96 2W99 2W9F 2W9Z 5VZU
Enriched GO Terms of Interacting Partners?
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