INSIG1 and HMGCR

Number of citations of the paper that reports this interaction (PubMedID 12535518)
109

Data Source:
HPRD (in vivo)

		INSIG1	HMGCR
Description		insulin induced gene 1	3-hydroxy-3-methylglutaryl-CoA reductase
Image
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane SREBP-SCAP-Insig Complex	Peroxisomal Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Integral Component Of Membrane
	Molecular Function	Protein Binding	Hydroxymethylglutaryl-CoA Reductase (NADPH) Activity Protein Binding Hydroxymethylglutaryl-CoA Reductase Activity Identical Protein Binding Coenzyme Binding Protein Phosphatase 2A Binding NADPH Binding
	Biological Process	Triglyceride Metabolic Process Cholesterol Biosynthetic Process Negative Regulation Of Steroid Biosynthetic Process SREBP Signaling Pathway Cellular Response To Sterol SREBP-SCAP Complex Retention In Endoplasmic Reticulum Inner Ear Morphogenesis Middle Ear Morphogenesis Cholesterol Homeostasis Negative Regulation Of Fat Cell Differentiation Negative Regulation Of Fatty Acid Biosynthetic Process Roof Of Mouth Development Cranial Suture Morphogenesis Negative Regulation Of Protein Exit From Endoplasmic Reticulum Negative Regulation Of Cargo Loading Into COPII-coated Vesicle	Cholesterol Biosynthetic Process Ubiquinone Metabolic Process Aging Response To Nutrient Isoprenoid Biosynthetic Process Visual Learning Negative Regulation Of Striated Muscle Cell Apoptotic Process Positive Regulation Of Cardiac Muscle Cell Apoptotic Process Coenzyme A Metabolic Process Sterol Biosynthetic Process Regulation Of Lipid Metabolic Process Positive Regulation Of Stress-activated MAPK Cascade Negative Regulation Of Protein Catabolic Process Negative Regulation Of MAP Kinase Activity Myoblast Differentiation Response To Ethanol Regulation Of Cholesterol Biosynthetic Process Positive Regulation Of Skeletal Muscle Tissue Development Positive Regulation Of Smooth Muscle Cell Proliferation Negative Regulation Of Protein Secretion Oxidation-reduction Process Negative Regulation Of Wound Healing Negative Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Positive Regulation Of ERK1 And ERK2 Cascade Negative Regulation Of Blood Vessel Diameter Negative Regulation Of Amyloid-beta Clearance
Pathways		Regulation of cholesterol biosynthesis by SREBP (SREBF)	EGR2 and SOX10-mediated initiation of Schwann cell myelination
Drugs			NADH Pravastatin Lovastatin Cerivastatin Simvastatin Atorvastatin Fluvastatin Rosuvastatin Coenzyme A (S)-Hmg-Coa 2'-Monophosphoadenosine 5'-Diphosphoribose 3-Hydroxy-3-Methyl-Glutaric Acid 1,4-Dithiothreitol TAK-475 Mevastatin Pitavastatin
Diseases
GWAS		Bladder cancer (smoking interaction) ( 24662972) Diverticular disease ( 30177863) Energy expenditure (24h) ( 28476931) Formal thought disorder in schizophrenia ( 22648509) Plasma anti-thyroglobulin and anti-thyroid peroxidase levels (bivariate analysis) ( 29678681) Plasma anti-thyroglobulin levels ( 29678681) Triiodothyronine levels and thyroxine levels ( 30843173)	Body mass index ( 20935630) Cholesterol, total ( 24097068 28270201 19060911 25961943 20686565 26582766) LDL cholesterol ( 24097068 18802019 18193044 20864672 19060906 19060911 25961943 20686565 26582766) LDL cholesterol levels ( 28334899) LDL cholesterol levels x long total sleep time interaction (2df test) ( 31719535) LDL cholesterol levels x short total sleep time interaction (2df test) ( 31719535) Lipid traits ( 24386095) Low density lipoprotein cholesterol levels ( 29403010) Medication use (HMG CoA reductase inhibitors) ( 31015401) Metabolite levels ( 21909109 23823483) Metabolite levels (lipoprotein measures) ( 27005778) Quantitative traits ( 19197348) Total cholesterol levels ( 28334899 30275531)
Interacting Genes		7 interacting genes: ELOC HMGCR PSMA7 PSMC3 SCAP SREBF2 VCP	4 interacting genes: ARHGAP1 INSIG1 PRKACA STARD13
Entrez ID		3638	3156
HPRD ID		03633	00836
Ensembl ID		ENSG00000186480	ENSG00000113161
Uniprot IDs		A0A024RD68 A4D2M9 F5H6P3 O15503	A0A024RAP2 P04035
PDB IDs		4J81	1DQ8 1DQ9 1DQA 1HW8 1HW9 1HWI 1HWJ 1HWK 1HWL 2Q1L 2Q6B 2Q6C 2R4F 3BGL 3CCT 3CCW 3CCZ 3CD0 3CD5 3CD7 3CDA 3CDB
Enriched GO Terms of Interacting Partners?
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