IMPDH2 and AMT

		IMPDH2	AMT
Description		inosine monophosphate dehydrogenase 2	aminomethyltransferase
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GO Annotations	Cellular Component	Extracellular Region Nucleus Cytoplasm Peroxisomal Membrane Cytosol Membrane Secretory Granule Lumen Extracellular Exosome Ficolin-1-rich Granule Lumen	Nucleoplasm Mitochondrion Mitochondrial Matrix
	Molecular Function	Nucleotide Binding DNA Binding RNA Binding IMP Dehydrogenase Activity Protein Binding Identical Protein Binding Metal Ion Binding	Aminomethyltransferase Activity Transaminase Activity
	Biological Process	GMP Biosynthetic Process GTP Biosynthetic Process Circadian Rhythm Purine Ribonucleoside Monophosphate Biosynthetic Process Neutrophil Degranulation Lymphocyte Proliferation Oxidation-reduction Process Retina Development In Camera-type Eye Cellular Response To Interleukin-4	Glycine Catabolic Process Glycine Decarboxylation Via Glycine Cleavage System
Pathways		Neutrophil degranulation Purine ribonucleoside monophosphate biosynthesis	Glycine degradation
Drugs		NADH Mycophenolate mofetil Ribavirin Mycophenolic acid Mercaptopurine Selenazole-4-Carboxyamide-Adenine Dinucleotide 6-Chloropurine Riboside, 5'-Monophosphate Inosinic Acid VX-148	Tetrahydrofolic acid NADH 5-methyltetrahydrofolic acid
Diseases			Nonketotic hyperglycinemia; Glycine encephalopathy (GCE)
GWAS		Blood protein levels ( 28240269) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Crohn's disease ( 28067908) Inflammatory bowel disease ( 28067908) Ulcerative colitis ( 28067908)	Blood protein levels ( 28240269) Cognitive function ( 25644384) Coronary artery disease ( 29212778) Crohn's disease ( 28067908) Depressive symptom (depressed mood) (binary trait) ( 31530331) Depressive symptoms (binary sum-score) ( 31530331) Extremely high intelligence ( 29520040) Gut microbiota (functional units) ( 27694959) Inflammatory bowel disease ( 28067908) Regular attendance at a religious group ( 29970889) Sleep duration (short sleep) ( 30846698) Ulcerative colitis ( 28067908)
Interacting Genes		24 interacting genes: AKT1 ALS2 AMT ANKRD9 APIP APPL1 ATXN2 ATXN7 C1S CEACAM5 CLK1 CPLANE2 DCAF1 DNASE1L3 FBXL7 KLF7 PIAS4 PRMT1 PXMP2 PXN RAD54L2 RBM15B SUMO4 UBQLN4	2 interacting genes: IMPDH2 RHOA
Entrez ID		3615	275
HPRD ID		00895	01997
Ensembl ID		ENSG00000178035	ENSG00000145020
Uniprot IDs		A0A384N6C2 P12268	A0A024R2U7 P48728
PDB IDs		1B3O 1NF7 1NFB 6I0M 6I0O	1WSR 1WSV
Enriched GO Terms of Interacting Partners?
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