ILK and FERMT2

Number of citations of the paper that reports this interaction (PubMedID 26344197)
117

Data Source:
BioGRID (biochemical, pull down, pull down, affinity chromatography technology)

		ILK	FERMT2
Description		integrin linked kinase	fermitin family member 2
Image
GO Annotations	Cellular Component	Stress Fiber Nucleoplasm Cytosol Plasma Membrane Cell-cell Junction Focal Adhesion Membrane Sarcomere Lamellipodium Cell Junction Protein-containing Complex Neuronal Cell Body Costamere Terminal Bouton Dendritic Shaft	Stress Fiber Nucleus Nucleoplasm Cytoplasm Cytosol Focal Adhesion Cell Cortex Cell Surface Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane Lamellipodium Membrane I Band
	Molecular Function	Protein Serine/threonine Kinase Activity Integrin Binding Protein Binding ATP Binding SH3 Domain Binding Protein Kinase Binding	Protein Binding Phosphatidylinositol-3,4,5-trisphosphate Binding Actin Filament Binding
	Biological Process	Branching Involved In Ureteric Bud Morphogenesis Positive Regulation Of Protein Phosphorylation Positive Regulation Of Cell-matrix Adhesion Outflow Tract Morphogenesis Protein Phosphorylation Negative Regulation Of Protein Kinase Activity Cell Cycle Arrest Cell-matrix Adhesion Integrin-mediated Signaling Pathway Cell Aging Positive Regulation Of Cell Proliferation Positive Regulation Of Signal Transduction Negative Regulation Of Cardiac Muscle Cell Apoptotic Process Fibroblast Migration Negative Regulation Of Smooth Muscle Cell Migration Peptidyl-serine Phosphorylation Nerve Development Myelination In Peripheral Nervous System Positive Regulation Of Cell Migration Positive Regulation Of BMP Signaling Pathway Myelin Assembly Regulation Of Actin Cytoskeleton Organization Tumor Necrosis Factor-mediated Signaling Pathway Cell Junction Assembly Substrate Adhesion-dependent Cell Spreading Positive Regulation Of Phosphorylation Positive Regulation Of MAP Kinase Activity Protein Kinase B Signaling Negative Regulation Of Neuron Apoptotic Process Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Positive Regulation Of Myoblast Differentiation Positive Regulation Of Osteoblast Differentiation Positive Regulation Of Axon Extension Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Smooth Muscle Cell Proliferation Neuron Projection Morphogenesis Positive Regulation Of Dendrite Morphogenesis Positive Regulation Of Protein Kinase B Signaling Platelet Aggregation Positive Regulation Of Canonical Wnt Signaling Pathway Supramolecular Fiber Organization Positive Regulation Of NIK/NF-kappaB Signaling Negative Regulation Of Neural Precursor Cell Proliferation	Cell-matrix Adhesion Transforming Growth Factor Beta Receptor Signaling Pathway Integrin-mediated Signaling Pathway Regulation Of Cell Shape Wnt Signaling Pathway Integrin Activation Cell Junction Assembly Substrate Adhesion-dependent Cell Spreading Focal Adhesion Assembly Protein Localization To Membrane
Pathways		Localization of the PINCH-ILK-PARVIN complex to focal adhesions Cell-extracellular matrix interactions	Cell-extracellular matrix interactions
Drugs
Diseases
GWAS			Alzheimer's disease (late onset) ( 24162737) Diastolic blood pressure ( 27841878) Glaucoma (primary angle closure) ( 27064256) Intraocular pressure ( 29617998 29785010 31959993 30054594) Post bronchodilator FEV1/FVC ratio ( 26634245) PR interval ( 30046033) Prostate cancer ( 23535732) Pulse pressure ( 27841878) Systolic blood pressure ( 28135244 27841878)
Interacting Genes		42 interacting genes: AKT1 AP2A2 CASP8 CASP9 CAV1 CKB FERMT1 FERMT2 FERMT3 GSK3B ILKAP ITGB1 ITGB2 ITGB3 LIMS1 LIMS2 MATK MBP MIPEP NCK2 NOTCH1 PARVA PARVB PARVG PDPK1 PPP1R12A PTPN11 PXN RICTOR RNF19A RPL13 SERPINA4 SHC1 SNRNP35 TMSB4X TRIM27 TWF2 ZBTB48 ZNF133 ZNF205 ZNF579 ZNF746	8 interacting genes: APP CMTM5 FBLIM1 ILK ITGB1 LIMS1 PARVA TRIM15
Entrez ID		3611	10979
HPRD ID		03842	06374
Ensembl ID		ENSG00000166333	ENSG00000073712
Uniprot IDs		Q13418 V9HWF0	A0A024R687 Q96AC1
PDB IDs		2KBX 3F6Q 3IXE 3KMU 3KMW 3REP 4HI8 4HI9 6MIB	2LGX 2LKO 2MSU 4F7H 6U4N
Enriched GO Terms of Interacting Partners?
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