IL12RB2 and IL12RB1

Number of citations of the paper that reports this interaction (PubMedID 8943050)
123

Data Source:
HPRD (in vitro, in vivo)

		IL12RB2	IL12RB1
Description		interleukin 12 receptor subunit beta 2	interleukin 12 receptor subunit beta 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane Receptor Complex	Plasma Membrane External Side Of Plasma Membrane Interleukin-12 Receptor Complex Receptor Complex Interleukin-23 Receptor Complex
	Molecular Function	Cytokine Receptor Activity Protein Kinase Binding Cytokine Binding	Cytokine Receptor Activity Interleukin-12 Receptor Binding Interleukin-12 Receptor Activity Cytokine Binding Interleukin-23 Binding Interleukin-23 Receptor Activity
	Biological Process	Cell Surface Receptor Signaling Pathway Positive Regulation Of Cell Proliferation Peptidyl-tyrosine Phosphorylation Response To Lipopolysaccharide Interferon-gamma Production Positive Regulation Of Interferon-gamma Production Interleukin-12-mediated Signaling Pathway Interleukin-35-mediated Signaling Pathway	Positive Regulation Of T Cell Mediated Cytotoxicity Positive Regulation Of Defense Response To Virus By Host Positive Regulation Of T-helper 1 Type Immune Response Signal Transduction Cytokine-mediated Signaling Pathway Positive Regulation Of Interferon-gamma Production Interleukin-12-mediated Signaling Pathway Interleukin-23-mediated Signaling Pathway Positive Regulation Of Activated T Cell Proliferation Positive Regulation Of Memory T Cell Differentiation Cellular Response To Interferon-gamma Positive Regulation Of T-helper 17 Type Immune Response Positive Regulation Of T-helper 17 Cell Lineage Commitment
Pathways		Interleukin-35 Signalling Interleukin-12 signaling Interleukin-12 signaling	Interleukin-12 signaling Interleukin-12 signaling Interleukin-23 signaling Interleukin-23 signaling
Drugs
Diseases			IFN-gamma/IL-12 axis, including the following five diseases: IL-12 p40 subunit deficiency; IL-12 receptor (IL-12R) beta1 chain deficiency; IFN-gamma receptor (IFN gamma R) alpha chain deficiency; IFN-gamma receptor (IFN gamma R) beta chain deficiency; STAT-1 deficiency
GWAS		Behcet's disease ( 20622878 20622879) Blood protein levels ( 30072576 29875488) Crohn's disease ( 28067908 22412388) Inflammatory bowel disease ( 28067908 23128233) Medication use (thyroid preparations) ( 31015401) Primary biliary cholangitis ( 19458352 21399635 20639880 26394269) Severe malaria ( 29381699) Severe malaria (adjusted for sickle cell variant rs334) ( 29381699) Systemic lupus erythematosus ( 26502338 28714469 19838195) Systemic sclerosis ( 31672989 29293537) Systemic seropositive rheumatic diseases (Systemic sclerosis or systemic lupus erythematosus or rheumatoid arthritis or idiopathic inflammatory myopathies) ( 30573655) Type 2 diabetes (age of onset) ( 28060188) Ulcerative colitis ( 28067908)	Blood protein levels ( 28240269) Mental health study participation (completed survey) ( 31263887) Pulmonary function in asthmatics ( 23541324) Systemic sclerosis ( 31672989)
Interacting Genes		5 interacting genes: IL12B IL12RB1 JAK2 SOCS3 STAT4	7 interacting genes: BRD4 IL12B IL12RB2 IL23A IL23R SNRPD3 STAT4
Entrez ID		3595	3594
HPRD ID		03383	03363
Ensembl ID		ENSG00000081985	ENSG00000096996
Uniprot IDs		A0A0A0MTN7 B4DGA4 B7ZB60 Q99665	P42701
PDB IDs
Enriched GO Terms of Interacting Partners?
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