IL12B and IL12A

Number of citations of the paper that reports this interaction (PubMedID 10899108)
45

Data Source:
HPRD (in vitro)

		IL12B	IL12A
Description		interleukin 12B	interleukin 12A
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Endoplasmic Reticulum Lumen Cytosol External Side Of Plasma Membrane Late Endosome Lumen Receptor Complex Interleukin-12 Complex Interleukin-23 Complex	Extracellular Region Extracellular Space Endoplasmic Reticulum Lumen Cell Surface Late Endosome Lumen Interleukin-12 Complex
	Molecular Function	Cytokine Receptor Activity Cytokine Activity Interleukin-12 Receptor Binding Protein Binding Growth Factor Activity Cytokine Binding Interleukin-12 Alpha Subunit Binding Identical Protein Binding Protein-containing Complex Binding Interleukin-23 Receptor Binding Protein Heterodimerization Activity	Cytokine Activity Interleukin-12 Receptor Binding Protein Binding Growth Factor Activity Interleukin-12 Beta Subunit Binding Interleukin-27 Binding Protein Heterodimerization Activity
	Biological Process	Positive Regulation Of T Cell Mediated Cytotoxicity Positive Regulation Of Defense Response To Virus By Host Natural Killer Cell Activation Involved In Immune Response Positive Regulation Of T-helper 1 Type Immune Response Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Directed Against Tumor Cell Target Negative Regulation Of Inflammatory Response To Antigenic Stimulus Cell Cycle Arrest Cell Proliferation Response To UV-B Positive Regulation Of Activation Of Janus Kinase Activity Cell Migration Cytokine-mediated Signaling Pathway Sensory Perception Of Pain Sexual Reproduction Natural Killer Cell Activation Negative Regulation Of Interleukin-10 Production Negative Regulation Of Interleukin-17 Production Positive Regulation Of Granulocyte Macrophage Colony-stimulating Factor Production Positive Regulation Of Interferon-gamma Production Positive Regulation Of Interleukin-10 Production Positive Regulation Of Interleukin-12 Production Positive Regulation Of Interleukin-17 Production Positive Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Natural Killer Cell Activation Positive Regulation Of Natural Killer Cell Proliferation Positive Regulation Of Mononuclear Cell Proliferation Positive Regulation Of Tissue Remodeling Positive Regulation Of Smooth Muscle Cell Apoptotic Process Interleukin-12-mediated Signaling Pathway T-helper 1 Cell Cytokine Production Interleukin-23-mediated Signaling Pathway Regulation Of Cytokine Biosynthetic Process T-helper 1 Type Immune Response T-helper Cell Differentiation Interferon-gamma Biosynthetic Process Positive Regulation Of T Cell Proliferation Positive Regulation Of Activated T Cell Proliferation Regulation Of Tyrosine Phosphorylation Of STAT Protein Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Defense Response To Protozoan Positive Regulation Of Memory T Cell Differentiation Positive Regulation Of Interferon-gamma Biosynthetic Process Positive Regulation Of Osteoclast Differentiation Positive Regulation Of Cell Adhesion Negative Regulation Of Smooth Muscle Cell Proliferation Positive Regulation Of Lymphocyte Proliferation Positive Regulation Of Inflammatory Response Defense Response To Gram-negative Bacterium Positive Regulation Of NK T Cell Activation Positive Regulation Of NK T Cell Proliferation Defense Response To Virus Cellular Response To Lipopolysaccharide Cellular Response To Interferon-gamma Positive Regulation Of NIK/NF-kappaB Signaling Positive Regulation Of T-helper 17 Type Immune Response Positive Regulation Of T-helper 17 Cell Lineage Commitment	Positive Regulation Of T Cell Mediated Cytotoxicity Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Directed Against Tumor Cell Target Immune Response Cell Cycle Arrest Cell Proliferation Response To Virus Response To UV-B Viral Process Cell Migration Cytokine-mediated Signaling Pathway Response To Lipopolysaccharide Negative Regulation Of Interleukin-17 Production Positive Regulation Of Interferon-gamma Production Positive Regulation Of Natural Killer Cell Activation Positive Regulation Of Mononuclear Cell Proliferation Positive Regulation Of Smooth Muscle Cell Apoptotic Process T-helper 1 Cell Activation Interleukin-12-mediated Signaling Pathway T-helper 1 Cell Cytokine Production Positive Regulation Of T Cell Proliferation Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Defense Response To Protozoan Positive Regulation Of T Cell Differentiation Positive Regulation Of Cell Adhesion Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Negative Regulation Of Smooth Muscle Cell Proliferation Positive Regulation Of Lymphocyte Proliferation Defense Response To Gram-positive Bacterium Positive Regulation Of NK T Cell Activation Interleukin-35-mediated Signaling Pathway Cellular Response To Lipopolysaccharide Extrinsic Apoptotic Signaling Pathway Cellular Response To Virus Positive Regulation Of Dendritic Cell Chemotaxis
Pathways		Interleukin-10 signaling Interleukin-4 and Interleukin-13 signaling Interleukin-12 signaling Interleukin-12 signaling Interleukin-23 signaling Interleukin-23 signaling	Interleukin-10 signaling Interleukin-4 and Interleukin-13 signaling Interleukin-35 Signalling Interleukin-12 signaling Interleukin-12 signaling
Drugs		5-Mercapto-2-Nitro-Benzoic Acid Briakinumab Ustekinumab Ustekinumab humanized SMART Anti-IL-12 Antibody Tapinarof
Diseases		IFN-gamma/IL-12 axis, including the following five diseases: IL-12 p40 subunit deficiency; IL-12 receptor (IL-12R) beta1 chain deficiency; IFN-gamma receptor (IFN gamma R) alpha chain deficiency; IFN-gamma receptor (IFN gamma R) beta chain deficiency; STAT-1 deficiency
GWAS		Ankylosing spondylitis ( 23749187 21743469) Blood protein levels ( 30072576 29875488) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Crohn's disease ( 18587394 30500874 28067908 17554261 20570966 21102463) Cutaneous psoriasis ( 26626624) Inflammatory bowel disease ( 28067908 26278503 23128233) interleukin 12 receptor subunit beta-1 levels ( 25147954) Leprosy ( 25642632) Multiple sclerosis ( 22190364 21833088) Pediatric autoimmune diseases ( 26301688) Primary biliary cholangitis ( 26394269) Psoriasis ( 25854761 25903422 20953188 20953190 23143594 19169254 19169255) Psoriasis vulgaris ( 26626624) Psoriatic arthritis ( 26626624 20953186) Response to taxane treatment (placlitaxel) ( 23006423) Sarcoidosis ( 26051272) Serum sulfate level ( 27412988) Takayasu arteritis ( 23830517) Ulcerative colitis ( 28067908 21297633)	Behcet's disease ( 23291587 27548383 25799145) Bipolar disorder ( 31043756) Celiac disease ( 22057235 20190752 25920553 18311140) Limited cutaneous systemic scleroderma ( 24387989) Major depressive disorder ( 23377640) Multiple sclerosis ( 24076602 19525953 21833088) Primary biliary cholangitis ( 28425483 19458352 21399635 20639880 26394269 28062665) Primary biliary cirrhosis ( 22961000) SjÃ¶gren's syndrome ( 24097067) Systemic lupus erythematosus ( 27399966 26502338 28714469) Systemic sclerosis ( 24387989 31672989)
Interacting Genes		3 interacting genes: IL12A IL12RB1 IL12RB2	5 interacting genes: CD28 CXCL8 EBI3 IL12B WASF1
Entrez ID		3593	3592
HPRD ID		01194	01193
Ensembl ID		ENSG00000113302	ENSG00000168811
Uniprot IDs		P29460	O60595 P29459
PDB IDs		1F42 1F45 3D85 3D87 3DUH 3HMX 3QWR 4GRW 5MJ3 5MJ4 5MXA 5MZV 5NJD	1F45 3HMX
Enriched GO Terms of Interacting Partners?
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