IL10 and IL10RA

Number of citations of the paper that reports this interaction (PubMedID 11485736)
45

Data Source:
HPRD (in vitro, in vivo)

		IL10	IL10RA
Description		interleukin 10	interleukin 10 receptor subunit alpha
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space	Cytoplasm Plasma Membrane Integral Component Of Membrane
	Molecular Function	Cytokine Activity Interleukin-10 Receptor Binding Protein Binding Growth Factor Activity Protein Dimerization Activity	Cytokine Receptor Activity Interleukin-10 Receptor Activity Protein Binding Interleukin-10 Binding Signaling Receptor Activity
	Biological Process	Negative Regulation Of Cytokine Production Positive Regulation Of Endothelial Cell Proliferation Response To Molecule Of Bacterial Origin Negative Regulation Of Cytokine Secretion Involved In Immune Response Negative Regulation Of Chronic Inflammatory Response To Antigenic Stimulus Positive Regulation Of B Cell Apoptotic Process Inflammatory Response Cytoplasmic Sequestering Of NF-kappaB Aging Negative Regulation Of Cell Proliferation Regulation Of Gene Expression Negative Regulation Of Autophagy Response To Activity Response To Inactivity Cytokine-mediated Signaling Pathway Hemopoiesis B Cell Differentiation Leukocyte Chemotaxis Negative Regulation Of Myeloid Dendritic Cell Activation Negative Regulation Of B Cell Proliferation Negative Regulation Of Interferon-gamma Production Negative Regulation Of Interleukin-1 Production Negative Regulation Of Interleukin-12 Production Negative Regulation Of Interleukin-18 Production Negative Regulation Of Interleukin-6 Production Negative Regulation Of Interleukin-8 Production Negative Regulation Of Tumor Necrosis Factor Production Receptor Biosynthetic Process Response To Insulin Negative Regulation Of Heterotypic Cell-cell Adhesion Positive Regulation Of Heterotypic Cell-cell Adhesion Response To Carbon Monoxide Interleukin-12-mediated Signaling Pathway Cellular Response To Hepatocyte Growth Factor Stimulus Type 2 Immune Response B Cell Proliferation Negative Regulation Of T Cell Proliferation Negative Regulation Of Tumor Necrosis Factor Biosynthetic Process Defense Response To Bacterium Defense Response To Protozoan Positive Regulation Of Macrophage Activation Negative Regulation Of Apoptotic Process Negative Regulation Of Neuron Apoptotic Process Negative Regulation Of Nitric Oxide Biosynthetic Process Regulation Of Isotype Switching Negative Regulation Of MHC Class II Biosynthetic Process Positive Regulation Of MHC Class II Biosynthetic Process Negative Regulation Of Interferon-alpha Biosynthetic Process Positive Regulation Of Cell Cycle Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Mitotic Cell Cycle Positive Regulation Of JAK-STAT Cascade Positive Regulation Of Cytokine Secretion Negative Regulation Of Inflammatory Response Regulation Of Synapse Organization Negative Regulation Of Membrane Protein Ectodomain Proteolysis Positive Regulation Of DNA-binding Transcription Factor Activity Response To Glucocorticoid Negative Regulation Of Cytokine Activity Branching Involved In Labyrinthine Layer Morphogenesis Cellular Response To Lipopolysaccharide Cellular Response To Estradiol Stimulus Negative Regulation Of Chemokine (C-C Motif) Ligand 5 Production Endothelial Cell Apoptotic Process Liver Regeneration Positive Regulation Of Pri-miRNA Transcription By RNA Polymerase II Regulation Of Response To Wounding Negative Regulation Of Hydrogen Peroxide-induced Neuron Death Regulation Of Complement-dependent Cytotoxicity Positive Regulation Of Sprouting Angiogenesis Negative Regulation Of Sensory Perception Of Pain Negative Regulation Of Vascular Smooth Muscle Cell Proliferation Positive Regulation Of Vascular Smooth Muscle Cell Proliferation Negative Regulation Of Endothelial Cell Apoptotic Process	Negative Regulation Of Autophagy Cytokine-mediated Signaling Pathway Response To Lipopolysaccharide Positive Regulation Of JAK-STAT Cascade Regulation Of Synapse Organization Ubiquitin-dependent Endocytosis
Pathways		Interleukin-10 signaling Interleukin-4 and Interleukin-13 signaling Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation CD163 mediating an anti-inflammatory response FCGR3A-mediated IL10 synthesis	Interleukin-10 signaling
Drugs		CRx-139 LLL-3348
Diseases		Graft-versus-host disease Allograft rejection
GWAS		Acute anterior uveitis (with or without ankylosing spondylitis) ( 25200001) Behcet's disease ( 20622878 20622879) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Crohn's disease ( 28067908 21102463) Gut microbiota (functional units) ( 27694959) Inflammatory bowel disease ( 28008999 28067908 23128233) Itch intensity from mosquito bite ( 28199695) Mosquito bite size ( 28199695) Pediatric autoimmune diseases ( 26301688) Systemic lupus erythematosus ( 26502338 28714469 19838195) Type 1 diabetes ( 21829393 25751624 19430480) Ulcerative colitis ( 19915572 28067908 26398853 20228798 20228799 18836448 21297633)	Obesity-related traits ( 23251661)
Interacting Genes		3 interacting genes: A2M IL10RA IL10RB	3 interacting genes: IL10 IL10RB JAK1
Entrez ID		3586	3587
HPRD ID		00495	00911
Ensembl ID		ENSG00000136634	ENSG00000110324
Uniprot IDs		P22301 Q6FGW4	Q13651
PDB IDs		1ILK 1INR 1J7V 1LK3 1Y6K 2H24 2ILK	1J7V 1LQS 1Y6K 1Y6M 1Y6N 5IXI
Enriched GO Terms of Interacting Partners?
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