IL4 and IL4R

Number of citations of the paper that reports this interaction (PubMedID 11786020)
16

Data Source:
HPRD (in vivo, in vitro)

		IL4	IL4R
Description		interleukin 4	interleukin 4 receptor
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space	Extracellular Space Nucleoplasm Plasma Membrane Integral Component Of Plasma Membrane Centriolar Satellite Receptor Complex
	Molecular Function	Cytokine Activity Interleukin-4 Receptor Binding Protein Binding Growth Factor Activity	Interleukin-4 Receptor Activity Protein Binding
	Biological Process	Immune Response Cholesterol Metabolic Process Positive Regulation Of Gene Expression Negative Regulation Of Epithelial Cell Migration Positive Regulation Of Macroautophagy Cytokine-mediated Signaling Pathway B Cell Differentiation Positive Regulation Of B Cell Proliferation Positive Regulation Of Interleukin-13 Production T-helper 2 Cell Cytokine Production Type 2 Immune Response Positive Regulation Of T Cell Proliferation T Cell Activation Regulation Of Phosphorylation Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Negative Regulation Of Tumor Necrosis Factor Biosynthetic Process Activation Of Janus Kinase Activity Myeloid Dendritic Cell Differentiation Negative Regulation Of Apoptotic Process Connective Tissue Growth Factor Biosynthetic Process Regulation Of Isotype Switching Positive Regulation Of MHC Class II Biosynthetic Process Positive Regulation Of T Cell Differentiation Negative Regulation Of Osteoclast Differentiation Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Receptor-mediated Endocytosis Positive Regulation Of Isotype Switching To IgE Isotypes Positive Regulation Of Isotype Switching To IgG Isotypes Regulation Of Immune Response Dendritic Cell Differentiation Positive Regulation Of Cold-induced Thermogenesis Neuroinflammatory Response Negative Regulation Of Neuroinflammatory Response Positive Regulation Of Amyloid-beta Clearance Positive Regulation Of Cellular Respiration Negative Regulation Of Complement-dependent Cytotoxicity Negative Regulation Of Endothelial Cell Apoptotic Process Positive Regulation Of ATP Biosynthetic Process	Production Of Molecular Mediator Involved In Inflammatory Response Positive Regulation Of Immunoglobulin Production Immune Response Signal Transduction Immunoglobulin Mediated Immune Response Cytokine-mediated Signaling Pathway Ovulation Interleukin-4-mediated Signaling Pathway Regulation Of Cell Proliferation Defense Response To Protozoan Positive Regulation Of Macrophage Activation Positive Regulation Of Mast Cell Degranulation Response To Estrogen Negative Regulation Of T-helper 1 Cell Differentiation Positive Regulation Of T-helper 2 Cell Differentiation Positive Regulation Of Chemokine Secretion Positive Regulation Of Cold-induced Thermogenesis Positive Regulation Of Myoblast Fusion Response To Odorant
Pathways		Interleukin-4 and Interleukin-13 signaling Interleukin-18 signaling	Interleukin-4 and Interleukin-13 signaling
Drugs			AER001 Dupilumab
Diseases		Asthma	Asthma
GWAS		Asthma ( 31619474 29273806) Asthma (childhood onset) ( 31036433 29273806) Asthma or allergic disease (pleiotropy) ( 29785011) Atopic dermatitis ( 25574825) Atopic march ( 26542096) Inflammatory bowel disease ( 23128233) Psoriasis ( 25574825 23143594) Psoriasis vulgaris ( 26626624)	Asthma ( 31361310 30929738 31619474) Asthma (adult onset) ( 30929738) Asthma (childhood onset) ( 31036433 30929738) Asthma (time to onset) ( 27130862) Asthma onset (childhood vs adult) ( 30929738) Eosinophil counts ( 27863252) Eosinophil percentage of white cells ( 27863252) IgE levels ( 22075330) Leprosy ( 27976721) Medication use (adrenergics, inhalants) ( 31015401) Night sleep phenotypes ( 27126917) Primary biliary cholangitis ( 28425483 26394269) Self-reported allergy ( 23817569) Serum IgE levels ( 25488688) Sum eosinophil basophil counts ( 27863252)
Interacting Genes		7 interacting genes: A2M CD53 FBXO7 IL13RA2 IL2RG IL4R PIK3CD	22 interacting genes: ARIH2 CD40 DOK2 FES HGS IL13 IL13RA1 IL2RG IL4 INPP5D IRS1 IRS2 JAK1 JAK2 JAK3 PRKCZ PTPN11 PTPN6 RACK1 SHC1 SOCS5 STAT6
Entrez ID		3565	3566
HPRD ID		00989	00990
Ensembl ID		ENSG00000113520	ENSG00000077238
Uniprot IDs		D4HNR6 P05112 Q5FC01	B2RBY1 P24394
PDB IDs		1BBN 1BCN 1CYL 1HIJ 1HIK 1HZI 1IAR 1ILL 1ITE 1ITI 1ITL 1ITM 1RCB 2B8U 2B8X 2B8Y 2B8Z 2B90 2B91 2CYK 2D48 2INT 3BPL 3BPN 3QB7 4YDY 5FHX 6OEL	1IAR 1IRS 1ITE 3BPL 3BPN 3BPO 5E4E 6OEL
Enriched GO Terms of Interacting Partners?
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